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6PB6
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BU of 6pb6 by Molmil
The E. coli class-II CAP-dependent transcription activation complex at the state 2
Descriptor: ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ...
Authors:Liu, B, Shi, W.
Deposit date:2019-06-13
Release date:2020-03-18
Last modified:2024-05-15
Method:ELECTRON MICROSCOPY (4.29 Å)
Cite:Visualization of two architectures in class-II CAP-dependent transcription activation
Plos Biol., 18, 2020
6PB5
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BU of 6pb5 by Molmil
The E. coli class-II CAP-dependent transcription activation complex at the state 1 architecture
Descriptor: ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ...
Authors:Liu, B, Shi, W.
Deposit date:2019-06-13
Release date:2020-03-18
Last modified:2024-03-20
Method:ELECTRON MICROSCOPY (4.52 Å)
Cite:Visualization of two architectures in class-II CAP-dependent transcription activation
Plos Biol., 18, 2020
5ZX2
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BU of 5zx2 by Molmil
Mycobacterium tuberculosis RNA polymerase transcription initiation complex with ECF sigma factor sigma H and 7nt RNA
Descriptor: DNA (47-MER), DNA (48-MER), DNA-directed RNA polymerase subunit alpha, ...
Authors:Li, L, Zhang, Y.
Deposit date:2018-05-17
Release date:2019-03-20
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural basis for transcription initiation by bacterial ECF sigma factors.
Nat Commun, 10, 2019
6KLE
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BU of 6kle by Molmil
Monomeric structure of Machupo virus polymerase bound to vRNA promoter
Descriptor: MANGANESE (II) ION, RNA (5'-R(*GP*CP*CP*UP*AP*GP*GP*AP*UP*CP*CP*AP*CP*UP*GP*UP*GP*CP*G)-3'), RNA-directed RNA polymerase L, ...
Authors:Peng, R, Xu, X, Jing, J, Peng, Q, Gao, G.F, Shi, Y.
Deposit date:2019-07-30
Release date:2020-03-18
Last modified:2024-10-30
Method:ELECTRON MICROSCOPY (4.5 Å)
Cite:Structural insight into arenavirus replication machinery.
Nature, 579, 2020
6KLH
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BU of 6klh by Molmil
Dimeric structure of Machupo virus polymerase bound to vRNA promoter
Descriptor: MANGANESE (II) ION, RNA (5'-R(*GP*CP*CP*UP*AP*GP*GP*AP*UP*CP*CP*AP*CP*UP*GP*UP*GP*CP*G)-3'), RNA-directed RNA polymerase L, ...
Authors:Peng, R, Xu, X, Jing, J, Peng, Q, Gao, G.F, Shi, Y.
Deposit date:2019-07-30
Release date:2020-03-18
Last modified:2024-11-06
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Structural insight into arenavirus replication machinery.
Nature, 579, 2020
6XZP
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BU of 6xzp by Molmil
Influenza C virus polymerase in complex with chicken ANP32A - Subclass 4
Descriptor: LRRcap domain-containing protein, Polymerase acidic protein, Polymerase basic protein 2, ...
Authors:Carrique, L, Keown, J.R, Fan, H, Grimes, J.M, Fodor, E.
Deposit date:2020-02-05
Release date:2020-11-25
Last modified:2024-11-13
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Host ANP32A mediates the assembly of the influenza virus replicase.
Nature, 587, 2020
6XZG
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BU of 6xzg by Molmil
Influenza C virus polymerase in complex with chicken ANP32A - Subclass 3
Descriptor: Influenza viral RNA (vRNA) promoter 47mer, LRRcap domain-containing protein, Polymerase acidic protein, ...
Authors:Carrique, L, Keown, J.R, Fan, H, Grimes, J.M, Fodor, E.
Deposit date:2020-02-04
Release date:2020-11-25
Last modified:2024-11-13
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Host ANP32A mediates the assembly of the influenza virus replicase.
Nature, 587, 2020
6XZR
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BU of 6xzr by Molmil
Influenza C virus polymerase in complex with chicken ANP32A - Subclass 1
Descriptor: LRRcap domain-containing protein, Polymerase acidic protein, Polymerase basic protein 2, ...
Authors:Carrique, L, Keown, J.R, Fan, H, Grimes, J.M, Fodor, E.
Deposit date:2020-02-05
Release date:2020-11-25
Last modified:2024-11-13
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Host ANP32A mediates the assembly of the influenza virus replicase.
Nature, 587, 2020
6KLC
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BU of 6klc by Molmil
Structure of apo Lassa virus polymerase
Descriptor: MANGANESE (II) ION, RNA-directed RNA polymerase L
Authors:Peng, R, Xu, X, Jing, J, Peng, Q, Gao, G.F, Shi, Y.
Deposit date:2019-07-30
Release date:2020-03-18
Last modified:2024-03-27
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Structural insight into arenavirus replication machinery.
Nature, 579, 2020
6KLD
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BU of 6kld by Molmil
Structure of apo Machupo virus polymerase
Descriptor: MANGANESE (II) ION, RNA-directed RNA polymerase L, ZINC ION
Authors:Peng, R, Xu, X, Jing, J, Peng, Q, Gao, G.F, Shi, Y.
Deposit date:2019-07-30
Release date:2020-03-18
Last modified:2024-10-09
Method:ELECTRON MICROSCOPY (3.58 Å)
Cite:Structural insight into arenavirus replication machinery.
Nature, 579, 2020
6FHI
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BU of 6fhi by Molmil
Crystal structure of bat influenza A/H17N10 polymerase with viral RNA promoter bound to a 19-mer serine 5 phosphorylated Pol II CTD peptide with a truncated linker.
Descriptor: PHOSPHATE ION, Polymerase acidic protein, Polymerase basic protein 2, ...
Authors:Lukarska, M, Cusack, S.
Deposit date:2018-01-14
Release date:2019-01-30
Last modified:2024-11-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Towards New Anti-Influenza Therapeutics: Structure-Activity Relationships in the Interaction between Heterotrimeric Influenza Polymerase and Pol II C-terminal domain
To Be Published
6FHH
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BU of 6fhh by Molmil
Crystal structure of bat influenza A/H17N10 polymerase with viral RNA promoter bound to a 22-mer modified Pol II CTD peptide with serine 5 thiophosphorylated.
Descriptor: PHOSPHATE ION, Polymerase acidic protein, Polymerase basic protein 2, ...
Authors:Lukarska, M, Cusack, S.
Deposit date:2018-01-14
Release date:2019-01-30
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Towards New Anti-Influenza Therapeutics: Structure-Activity Relationships in the Interaction between Heterotrimeric Influenza Polymerase and Pol II C-terminal domain
To Be Published
6N62
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BU of 6n62 by Molmil
Escherichia coli RNA polymerase sigma70-holoenzyme bound to upstream fork promoter DNA
Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
Authors:Braffman, N, Hauver, J, Campbell, E.A, Darst, S.A.
Deposit date:2018-11-24
Release date:2019-01-09
Last modified:2024-10-23
Method:X-RAY DIFFRACTION (3.803 Å)
Cite:Structural mechanism of transcription inhibition by lasso peptides microcin J25 and capistruin.
Proc. Natl. Acad. Sci. U.S.A., 116, 2019
6N61
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BU of 6n61 by Molmil
Escherichia coli RNA polymerase sigma70-holoenzyme bound to upstream fork promoter DNA and Capistruin
Descriptor: 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Capistruin, ...
Authors:Braffman, N, Hauver, J, Campbell, E.A, Darst, S.A.
Deposit date:2018-11-24
Release date:2019-01-09
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3.253 Å)
Cite:Structural mechanism of transcription inhibition by lasso peptides microcin J25 and capistruin.
Proc. Natl. Acad. Sci. U.S.A., 116, 2019
6N60
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BU of 6n60 by Molmil
Escherichia coli RNA polymerase sigma70-holoenzyme bound to upstream fork promoter DNA and Microcin J25 (MccJ25)
Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
Authors:Braffman, N, Hauver, J, Campbell, E.A, Darst, S.A.
Deposit date:2018-11-23
Release date:2019-01-09
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3.68 Å)
Cite:Structural mechanism of transcription inhibition by lasso peptides microcin J25 and capistruin.
Proc. Natl. Acad. Sci. U.S.A., 116, 2019
8PNT
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BU of 8pnt by Molmil
Structure of the human nuclear cap-binding complex bound to PHAX and m7G-capped RNA
Descriptor: 7N-METHYL-8-HYDROGUANOSINE-5'-TRIPHOSPHATE, Nuclear cap-binding protein subunit 1, Nuclear cap-binding protein subunit 2, ...
Authors:Dubiez, E, Pellegrini, E, Foucher, A.E, Cusack, S, Kadlec, J.
Deposit date:2023-07-01
Release date:2024-01-17
Method:ELECTRON MICROSCOPY (3.46 Å)
Cite:Structural basis for competitive binding of productive and degradative co-transcriptional effectors to the nuclear cap-binding complex.
Cell Rep, 43, 2024
6N4C
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BU of 6n4c by Molmil
EM structure of the DNA wrapping in bacterial open transcription initiation complex
Descriptor: DNA (94-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ...
Authors:Florez-Ariza, A, Cassago, A, de Oliveira, P.S.L, Guerra, D.G, Portugal, R.V.
Deposit date:2018-11-19
Release date:2020-05-27
Last modified:2024-11-06
Method:ELECTRON MICROSCOPY (17 Å)
Cite:Interactions of Upstream and Downstream Promoter Regions with RNA Polymerase are Energetically Coupled and a Target of Regulation in Transcription Initiation
Biorxiv, 2020
5N8X
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BU of 5n8x by Molmil
Trigonal structure of mutant V173I of 3D polymerase from Foot-and-Mouth Disease Virus
Descriptor: 3D polymerase, GLYCEROL, MANGANESE (II) ION
Authors:Ferrer-Orta, C, Verdaguer, N.
Deposit date:2017-02-24
Release date:2017-05-10
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Molecular and Functional Bases of Selection against a Mutation Bias in an RNA Virus.
Genome Biol Evol, 9, 2017
9F37
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BU of 9f37 by Molmil
Replication-like initiation state of influenza polymerase with GTP and CTP at respectively the -1 and +1 positions (strain A/little yellow-shouldered bat/Guatemala/060/2010/H17N10)
Descriptor: 3' end of the vRNA promoter, 5' end of the vRNA promoter, 7N-METHYL-8-HYDROGUANOSINE-5'-TRIPHOSPHATE, ...
Authors:Cusack, S, Drncova, P.
Deposit date:2024-04-25
Release date:2024-09-18
Method:X-RAY DIFFRACTION (1.905 Å)
Cite:High-resolution structure of a replication-initiation like configuration of influenza polymerase active site visualises the essential role of a conserved dibasic motif in the PA subunit
Biorxiv, 2024
5M9Z
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BU of 5m9z by Molmil
Second zinc-binding domain from yeast Pcf11
Descriptor: Protein PCF11, ZINC ION
Authors:Mackereth, C.
Deposit date:2016-11-02
Release date:2017-08-02
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:Distinct roles of Pcf11 zinc-binding domains in pre-mRNA 3'-end processing.
Nucleic Acids Res., 45, 2017
8PBL
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BU of 8pbl by Molmil
E. coli RNA polymerase elongation complex stalled at thymine dimer lesion
Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
Authors:Woodgate, J, Zenkin, N.
Deposit date:2023-06-09
Release date:2023-10-25
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (2.87 Å)
Cite:Translation selectively destroys non-functional transcription complexes.
Nature, 626, 2024
1N35
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BU of 1n35 by Molmil
lambda3 elongation complex with four phosphodiester bond formed
Descriptor: 3'-DEOXY-CYTIDINE-5'-TRIPHOSPHATE, 5'-R(*AP*UP*UP*AP*GP*CP*CP*CP*CP*C)-3', 5'-R(P*GP*GP*GP*GP*G)-3', ...
Authors:Tao, Y, Farsetta, D.L, Nibert, M.L, Harrison, S.C.
Deposit date:2002-10-25
Release date:2002-12-25
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:RNA Synthesis in a Cage--Structural Studies of Reovirus Polymerase [lambda] 3
Cell(Cambridge,Mass.), 111, 2002
7QXI
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BU of 7qxi by Molmil
Cryo-EM structure of RNA polymerase-sigma54 holo enzyme with promoter DNA closed complex
Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
Authors:Ye, F.Z, Zhang, X.D.
Deposit date:2022-01-26
Release date:2022-11-09
Last modified:2024-07-17
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Mechanisms of DNA opening revealed in AAA+ transcription complex structures.
Sci Adv, 8, 2022
6FLP
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BU of 6flp by Molmil
CryoEM structure of E.coli RNA polymerase paused elongation complex without RNA hairpin bound to NusA
Descriptor: DNA (30-MER), DNA (39-MER), DNA-directed RNA polymerase subunit alpha, ...
Authors:Guo, X, Weixlbaumer, A.
Deposit date:2018-01-26
Release date:2018-03-07
Last modified:2025-07-09
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:Structural Basis for NusA Stabilized Transcriptional Pausing.
Mol. Cell, 69, 2018
8FYH
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BU of 8fyh by Molmil
G4 RNA-mediated PRC2 dimer
Descriptor: G4 RNA, Histone-binding protein RBBP4, Histone-lysine N-methyltransferase EZH2, ...
Authors:Song, J, Kasinath, V.
Deposit date:2023-01-26
Release date:2023-10-04
Last modified:2024-10-30
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Structural basis for inactivation of PRC2 by G-quadruplex RNA.
Science, 381, 2023

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