6FHH
Crystal structure of bat influenza A/H17N10 polymerase with viral RNA promoter bound to a 22-mer modified Pol II CTD peptide with serine 5 thiophosphorylated.
Summary for 6FHH
Entry DOI | 10.2210/pdb6fhh/pdb |
Descriptor | Polymerase acidic protein, RNA-directed RNA polymerase catalytic subunit, Polymerase basic protein 2, ... (9 entities in total) |
Functional Keywords | influenza virus, rna-dependent rna polymerase, viral protein, modified pol ii ctd peptide |
Biological source | Influenza A virus (A/little yellow-shouldered bat/Guatemala/060/2010(H17N10)) More |
Total number of polymer chains | 7 |
Total formula weight | 282033.96 |
Authors | Lukarska, M.,Cusack, S. (deposition date: 2018-01-14, release date: 2019-01-30, Last modification date: 2024-02-07) |
Primary citation | Claron, M.,Lukarska, M.,Uhrig, U.,Sehr, P.,Drncova, P.,Lewis, J.D.,Will, D.W.,Cusack, S. Towards New Anti-Influenza Therapeutics: Structure-Activity Relationships in the Interaction between Heterotrimeric Influenza Polymerase and Pol II C-terminal domain To Be Published, |
Experimental method | X-RAY DIFFRACTION (2.7 Å) |
Structure validation
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