6FHH

Crystal structure of bat influenza A/H17N10 polymerase with viral RNA promoter bound to a 22-mer modified Pol II CTD peptide with serine 5 thiophosphorylated.

Summary for 6FHH

• Entry DOI: 10.2210/pdb6fhh/pdb
• Descriptor: Polymerase acidic protein, RNA-directed RNA polymerase catalytic subunit, Polymerase basic protein 2, ... (9 entities in total)
• Functional Keywords: influenza virus, rna-dependent rna polymerase, viral protein, modified pol ii ctd peptide
• Biological source: Influenza A virus (A/little yellow-shouldered bat/Guatemala/060/2010(H17N10)); More
• Total number of polymer chains: 7
• Total formula weight: 282033.96

Authors

Lukarska, M.,Cusack, S. (deposition date: 2018-01-14, release date: 2019-01-30, Last modification date: 2024-02-07)

• Primary citation: Claron, M.,Lukarska, M.,Uhrig, U.,Sehr, P.,Drncova, P.,Lewis, J.D.,Will, D.W.,Cusack, S.; Towards New Anti-Influenza Therapeutics: Structure-Activity Relationships in the Interaction between Heterotrimeric Influenza Polymerase and Pol II C-terminal domain; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.7 Å)