PDB: 1870 resultsInfo pagesStatus searchChemie searchBIRD

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6FT6	Structure of the Nop53 pre-60S particle bound to the exosome nuclear cofactors Descriptor: 25S ribosomal RNA, 5S ribosomal RNA, 60S ribosomal protein L11-A, ... Authors: Schuller, J.M, Falk, S, Conti, E. Deposit date: 2018-02-20 Release date: 2018-03-28 Last modified: 2019-12-11 Method: ELECTRON MICROSCOPY (3.9 Å) Cite: Structure of the nuclear exosome captured on a maturing preribosome. Science, 360, 2018
8PYR	Crystal structure of the dual T-loop phosphorylated Cdk7/CycH/Mat1 complex Descriptor: 1,2-ETHANEDIOL, CDK-activating kinase assembly factor MAT1, Cyclin-H, ... Authors: Anand, K, Duster, R, Geyer, M. Deposit date: 2023-07-26 Release date: 2024-03-06 Method: X-RAY DIFFRACTION (2.15 Å) Cite: Structural basis of Cdk7 activation by dual T-loop phosphorylation. Biorxiv, 2024
8R0S	Structure of reverse transcriptase from Cauliflower Mosaic Virus in complex with RNA/DNA hybrid Descriptor: DNA (5'-D(*GP*CP*TP*AP*CP*GP*CP*AP*CP*TP*GP*CP*TP*GP*GP*A)-3'), Enzymatic polyprotein, RNA (5'-R(*GP*UP*CP*CP*AP*GP*CP*AP*GP*UP*GP*CP*GP*UP*AP*GP*C)-3') Authors: Prabaharan, C, Figiel, M, Chamera, S, Szczepanowski, R, Nowak, E, Nowotny, M. Deposit date: 2023-10-31 Release date: 2024-07-24 Method: X-RAY DIFFRACTION (2.35 Å) Cite: Structural and biochemical characterization of cauliflower mosaic virus reverse transcriptase. J.Biol.Chem., 2024
5FGO	Crystal structure of D. melanogaster Pur-alpha repeat III. Descriptor: CG1507-PB, isoform B, CHLORIDE ION Authors: Windhager, A, Janowski, R, Niessing, D. Deposit date: 2015-12-21 Release date: 2016-01-20 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Structural basis of nucleic-acid recognition and double-strand unwinding by the essential neuronal protein Pur-alpha. Elife, 5, 2016
5LYV	The crystal structure of 7SK 5'-hairpin - Osmium derivative Descriptor: 7SK RNA, CHLORIDE ION, MAGNESIUM ION, ... Authors: Martinez-Zapien, D, Legrand, P, McEwen, A.G, Pasquali, S, Dock-Bregeon, A.-C. Deposit date: 2016-09-28 Release date: 2017-01-25 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2.35 Å) Cite: The crystal structure of the 5 functional domain of the transcription riboregulator 7SK. Nucleic Acids Res., 45, 2017
1AUI	HUMAN CALCINEURIN HETERODIMER Descriptor: CALCIUM ION, FE (III) ION, SERINE/THREONINE PHOSPHATASE 2B, ... Authors: Kissinger, C.R, Parge, H.E, Knighton, D.R, Pelletier, L.A, Lewis, C.T, Tempczyk, A, Villafranca, J.E. Deposit date: 1997-08-27 Release date: 1997-12-03 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Crystal structures of human calcineurin and the human FKBP12-FK506-calcineurin complex. Nature, 378, 1995
5VHE	DHX36 in complex with the c-Myc G-quadruplex Descriptor: DEAH (Asp-Glu-Ala-His) box polypeptide 36, DNA (5'-D(*AP*GP*GP*GP*TP*GP*GP*GP*TP*AP*GP*GP*GP*TP*GP*GP*GP*TP*TP*TP*TP*TP*TP*T)-3'), POTASSIUM ION Authors: Chen, M, Ferre-D'Amare, A. Deposit date: 2017-04-13 Release date: 2018-06-13 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (3.793 Å) Cite: Structural basis of G-quadruplex unfolding by the DEAH/RHA helicase DHX36. Nature, 558, 2018
7KTS	Negative stain EM structure of the human SAGA coactivator complex (TRRAP, core, splicing module) Descriptor: Ataxin-7, Isoform 3 of Transcription factor SPT20 homolog, STAGA complex 65 subunit gamma, ... Authors: Herbst, D.A, Esbin, M.N, Nogales, E. Deposit date: 2020-11-24 Release date: 2021-11-10 Last modified: 2024-05-29 Method: ELECTRON MICROSCOPY (19.09 Å) Cite: Structure of the human SAGA coactivator complex. Nat.Struct.Mol.Biol., 28, 2021
8QU8	PROTAC-mediated complex of KRAS with VHL/Elongin-B/Elongin-C/Cullin-2/Rbx1 Descriptor: (2S,4R)-1-[(2S)-2-[4-[4-[(3S)-4-[4-[5-[(4S)-2-azanyl-3-cyano-4-methyl-6,7-dihydro-5H-1-benzothiophen-4-yl]-1,2,4-oxadiazol-3-yl]pyrimidin-2-yl]-3-methyl-1,4-diazepan-1-yl]butoxy]-1,2,3-triazol-1-yl]-3-methyl-butanoyl]-N-[(1R)-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]-2-oxidanyl-ethyl]-4-oxidanyl-pyrrolidine-2-carboxamide, Cullin-2, E3 ubiquitin-protein ligase RBX1, ... Authors: Fischer, G, Peter, D, Arce-Solano, S. Deposit date: 2023-10-14 Release date: 2023-12-06 Last modified: 2024-01-24 Method: ELECTRON MICROSCOPY (3.5 Å) Cite: Targeting cancer with small molecule pan-KRAS degraders Biorxiv, 2023
3LK9	DNA polymerase beta with a gapped DNA substrate and dTMP(CF2)P(CF2)P Descriptor: 5'-O-[(R)-{[(R)-[difluoro(phosphono)methyl](hydroxy)phosphoryl](difluoro)methyl}(hydroxy)phosphoryl]thymidine, CHLORIDE ION, DNA (5'-D(*CP*CP*GP*AP*CP*AP*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), ... Authors: Zibinsky, M, Surya Prakash, G.K, Upton, T.G, Kashemirov, B.A, McKenna, C.E, Oertell, K, Goodman, M.F, Batra, V.K, Pedersen, L.C, Beard, W.A, Wilson, S.H. Deposit date: 2010-01-27 Release date: 2011-01-12 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Synthesis and biological evaluation of fluorinated deoxynucleotide analogs based on bis-(difluoromethylene)triphosphoric acid. Proc.Natl.Acad.Sci.USA, 107, 2010
7KTR	Cryo-EM structure of the human SAGA coactivator complex (TRRAP, core) Descriptor: Ataxin-7, INOSITOL HEXAKISPHOSPHATE, Isoform 3 of Transcription factor SPT20 homolog, ... Authors: Herbst, D.A, Esbin, M.N, Nogales, E. Deposit date: 2020-11-24 Release date: 2021-11-10 Last modified: 2024-05-29 Method: ELECTRON MICROSCOPY (2.93 Å) Cite: Structure of the human SAGA coactivator complex. Nat.Struct.Mol.Biol., 28, 2021
2JV6	YF ED3 Protein NMR Structure Descriptor: Envelope protein E Authors: Volk, D.E, Gandham, S.H.A, May, F.J, Anderson, A, Barrett, A.D.T, Gorenstein, D.G. Deposit date: 2007-09-12 Release date: 2008-09-16 Last modified: 2022-03-16 Method: SOLUTION NMR Cite: Yellow Fever Virus Envelope Protein Domain III: A Convergence of Structure and Phylogenetics To be Published
8CR8	human Interleukin-23 Descriptor: Interleukin-12 subunit beta, Interleukin-23 subunit alpha, TERBIUM(III) ION, ... Authors: Bloch, Y, Savvides, S.N. Deposit date: 2023-03-08 Release date: 2024-02-07 Last modified: 2024-05-01 Method: X-RAY DIFFRACTION (2 Å) Cite: Structures of complete extracellular receptor assemblies mediated by IL-12 and IL-23. Nat.Struct.Mol.Biol., 31, 2024
6YWN	CutA in complex with CMPCPP Descriptor: 5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]methyl}phosphoryl]cytidine, CALCIUM ION, CutA Authors: Malik, D, Kobylecki, K, Krawczyk, P, Poznanski, J, Jakielaszek, A, Napiorkowska, A, Dziembowski, A, Tomecki, R, Nowotny, M. Deposit date: 2020-04-29 Release date: 2020-08-05 Last modified: 2020-09-30 Method: X-RAY DIFFRACTION (1.45 Å) Cite: Structure and mechanism of CutA, RNA nucleotidyl transferase with an unusual preference for cytosine. Nucleic Acids Res., 48, 2020
1K5M	Crystal Structure of a Human Rhinovirus Type 14:Human Immunodeficiency Virus Type 1 V3 Loop Chimeric Virus MN-III-2 Descriptor: CHIMERA OF HRV14 COAT PROTEIN VP2 (P1B) AND the V3 loop of HIV-1 gp120, COAT PROTEIN VP1 (P1D), COAT PROTEIN VP3 (P1C), ... Authors: Ding, J, Smith, A.D, Geisler, S.C, Ma, X, Arnold, G.F, Arnold, E. Deposit date: 2001-10-11 Release date: 2002-07-17 Last modified: 2023-08-16 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Crystal Structure of a Human Rhinovirus that Displays Part of the HIV-1 V3 Loop and Induces Neutralizing Antibodies against HIV-1 Structure, 10, 2002
6NZ2	NMR solution structure of Bcd1p120-303 from Saccharomyces cerevisiae Descriptor: Box C/D snoRNA protein 1 Authors: Bragantini, B, Quinternet, M, Charpentier, B, Manival, X. Deposit date: 2019-02-12 Release date: 2020-08-19 Last modified: 2024-05-15 Method: SOLUTION NMR Cite: The box C/D snoRNP assembly factor Bcd1 interacts with the histone chaperone Rtt106 and controls its transcription dependent activity. Nat Commun, 12, 2021
8FY2	E3:PROTAC:target ternary complex structure (VCB/WH244/BCL-2) Descriptor: Apoptosis regulator Bcl-2, Elongin-B, Elongin-C, ... Authors: Nayak, D, Lv, D, Yuan, Y, Zhang, P, Hu, W, Ruben, E, Lv, Z, Sung, P, Hromas, R, Zheng, G, Zhou, D, Olsen, S.K. Deposit date: 2023-01-25 Release date: 2024-04-10 Method: X-RAY DIFFRACTION (2.98 Å) Cite: Development and crystal structures of a potent second-generation dual degrader of BCL-2 and BCL-xL. Nat Commun, 15, 2024
8FY0	E3:PROTAC:target ternary complex structure (VCB/753b/BCL-xL) Descriptor: Bcl-2-like protein 1, CACODYLIC ACID, Elongin-B, ... Authors: Olsen, S.K, Nayak, D, Lv, D, Yuan, Y, Zhang, P, Hu, W, Lv, Z, Sung, P, Hromas, R, Zheng, G, Zhou, D. Deposit date: 2023-01-25 Release date: 2024-04-10 Method: X-RAY DIFFRACTION (2.94 Å) Cite: Development and crystal structures of a potent second-generation dual degrader of BCL-2 and BCL-xL. Nat Commun, 15, 2024
8FY1	E3:PROTAC:target ternary complex structure (VCB/753b/BCL-2) Descriptor: Apoptosis regulator Bcl-2, Elongin-B, Elongin-C, ... Authors: Nayak, D, Lv, D, Yuan, Y, Zhang, P, Hu, W, Lv, Z, Sung, P, Hromas, R, Zheng, G, Zhou, D, Olsen, S.K. Deposit date: 2023-01-25 Release date: 2024-04-10 Method: X-RAY DIFFRACTION (2.56 Å) Cite: Development and crystal structures of a potent second-generation dual degrader of BCL-2 and BCL-xL. Nat Commun, 15, 2024
1QJU	HUMAN RHINOVIRUS 16 COAT PROTEIN IN COMPLEX WITH ANTIVIRAL COMPOUND VP61209 Descriptor: 2,6-DIMETHYL-1-(3-[3-METHYL-5-ISOXAZOLYL]-PROPANYL)-4-[2N-METHYL-2H-TETRAZOL-5-YL]-PHENOL, MYRISTIC ACID, PROTEIN VP1, ... Authors: Hadfield, A.T, Minor, I, Diana, G.D, Rossmann, M.G. Deposit date: 1999-07-05 Release date: 1999-07-20 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Analysis of Three Structurally Related Antiviral Compounds in Complex with Human Rhinovirus 16 Proc.Natl.Acad.Sci.USA, 96, 1999
1QJY	HUMAN RHINOVIRUS 16 COAT PROTEIN IN COMPLEX WITH ANTIVIRAL COMPOUND VP65099 Descriptor: 2,6-DIMETHYL-1-(3-[3-METHYL-5-ISOXAZOLYL]-PROPANYL)-4-[2-METHYL-4-ISOXAZOLYL]-PHENOL, MYRISTIC ACID, PROTEIN VP1, ... Authors: Hadfield, A.T, Diana, G.D, Rossmann, M.G. Deposit date: 1999-07-06 Release date: 1999-07-20 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Analysis of Three Structurally Related Antiviral Compounds in Complex with Human Rhinovirus 16 Proc.Natl.Acad.Sci.USA, 96, 1999
4F7P	Crystal Structure of HLA-A*2402 Complexed with a Newly Identified Peptide from 2009H1N1 PB1 (496-505) Descriptor: Beta-2-microglobulin, HLA class I histocompatibility antigen, A-24 alpha chain, ... Authors: Liu, J, Zhang, S, Tan, S, Yi, Y, Wu, B, Zhu, F, Wang, H, Qi, J, Gao, G.F. Deposit date: 2012-05-16 Release date: 2012-10-10 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Cross-Allele Cytotoxic T Lymphocyte Responses against 2009 Pandemic H1N1 Influenza A Virus among HLA-A24 and HLA-A3 Supertype-Positive Individuals. J.Virol., 86, 2012
1HNI	STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN A COMPLEX WITH THE NONNUCLEOSIDE INHIBITOR ALPHA-APA R 95845 AT 2.8 ANGSTROMS RESOLUTION Descriptor: (2-ACETYL-5-METHYLANILINO)(2,6-DIBROMOPHENYL)ACETAMIDE, HIV-1 REVERSE TRANSCRIPTASE (SUBUNIT P51), HIV-1 REVERSE TRANSCRIPTASE (SUBUNIT P66) Authors: Ding, J, Das, K, Arnold, E. Deposit date: 1995-02-28 Release date: 1995-06-03 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Structure of HIV-1 reverse transcriptase in a complex with the non-nucleoside inhibitor alpha-APA R 95845 at 2.8 A resolution. Structure, 3, 1995
5O1T	Solution structure of the RNA binding domain of Nrd1 Descriptor: Protein NRD1 Authors: Martinez-Lumbreras, S, Perez-Canadillas, J.M. Deposit date: 2017-05-19 Release date: 2017-08-02 Last modified: 2024-06-19 Method: SOLUTION NMR Cite: The structure of transcription termination factor Nrd1 reveals an original mode for GUAA recognition. Nucleic Acids Res., 45, 2017
1E9N	A second divalent metal ion in the active site of a new crystal form of human apurinic/apyrimidinic endonuclease, Ape1, and its implications for the catalytic mechanism Descriptor: DNA-(APURINIC OR APYRIMIDINIC SITE) LYASE, LEAD (II) ION Authors: Beernink, P.T, Segelke, B.W, Rupp, B. Deposit date: 2000-10-24 Release date: 2001-02-16 Last modified: 2024-05-01 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Two Divalent Metal Ions in the Active Site of a New Crystal Form of Human Apurinic/Apyrimidinic Endonuclease, Ape1: Implications for the Catalytic Mechanism J.Mol.Biol., 307, 2001

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