3LK9

DNA polymerase beta with a gapped DNA substrate and dTMP(CF2)P(CF2)P

Summary for 3LK9

• Entry DOI: 10.2210/pdb3lk9/pdb
• Related: 3GDX
• Descriptor: DNA polymerase beta, DNA (5'-D(*CP*CP*GP*AP*CP*AP*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*C)-3'), ... (9 entities in total)
• Functional Keywords: nucleotidyl transferase, dna polyemrase, dna damage, dna repair, dna replication, dna synthesis, dna-binding, dna-directed dna polymerase, lyase, magnesium, metal-binding, methylation, nucleotidyltransferase, nucleus, transferase, transferase-dna complex, transferase/dna
• Biological source: Homo sapiens (human); More
• Cellular location: Nucleus: P06746
• Total number of polymer chains: 4
• Total formula weight: 48443.00

Authors

Zibinsky, M.,Surya Prakash, G.K.,Upton, T.G.,Kashemirov, B.A.,McKenna, C.E.,Oertell, K.,Goodman, M.F.,Batra, V.K.,Pedersen, L.C.,Beard, W.A.,Wilson, S.H. (deposition date: 2010-01-27, release date: 2011-01-12, Last modification date: 2023-09-06)

• Primary citation: Surya Prakash, G.K.,Zibinsky, M.,Upton, T.G.,Kashemirov, B.A.,McKenna, C.E.,Oertell, K.,Goodman, M.F.,Batra, V.K.,Pedersen, L.C.,Beard, W.A.,Shock, D.D.,Wilson, S.H.,Olah, G.A.; Synthesis and biological evaluation of fluorinated deoxynucleotide analogs based on bis-(difluoromethylene)triphosphoric acid.; Proc.Natl.Acad.Sci.USA, 107:15693-15698, 2010; PubMed: 20724659; DOI: 10.1073/pnas.1007430107

Experimental method

X-RAY DIFFRACTION (2.5 Å)