5X2H
| Crystal structure of Campylobacter jejuni Cas9 in complex with sgRNA and target DNA (AGAAACA PAM) | Descriptor: | 1,2-ETHANEDIOL, CRISPR-associated endonuclease Cas9, Non-target DNA strand, ... | Authors: | Yamada, M, Watanabe, Y, Hirano, H, Nakane, T, Ishitani, R, Nishimasu, H, Nureki, O. | Deposit date: | 2017-01-31 | Release date: | 2017-03-29 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Crystal Structure of the Minimal Cas9 from Campylobacter jejuni Reveals the Molecular Diversity in the CRISPR-Cas9 Systems Mol. Cell, 65, 2017
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3QIP
| Structure of HIV-1 reverse transcriptase in complex with an RNase H inhibitor and nevirapine | Descriptor: | 11-CYCLOPROPYL-5,11-DIHYDRO-4-METHYL-6H-DIPYRIDO[3,2-B:2',3'-E][1,4]DIAZEPIN-6-ONE, 5,6-dihydroxy-2-[(2-phenyl-1H-indol-3-yl)methyl]pyrimidine-4-carboxylic acid, CHLORIDE ION, ... | Authors: | Lansdon, E.B, Kirschberg, T.A. | Deposit date: | 2011-01-27 | Release date: | 2011-04-20 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.0926 Å) | Cite: | Structural and Binding Analysis of Pyrimidinol Carboxylic Acid and N-Hydroxy Quinazolinedione HIV-1 RNase H Inhibitors. Antimicrob.Agents Chemother., 55, 2011
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4N0T
| Core structure of the U6 small nuclear ribonucleoprotein at 1.7 Angstrom resolution | Descriptor: | SULFATE ION, U4/U6 snRNA-associated-splicing factor PRP24, U6 snRNA | Authors: | Montemayor, E.J, Curran, E.C, Liao, H, Andrews, K.L, Treba, C.N, Butcher, S.E, Brow, D.A. | Deposit date: | 2013-10-02 | Release date: | 2014-05-14 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Core structure of the U6 small nuclear ribonucleoprotein at 1.7- angstrom resolution. Nat.Struct.Mol.Biol., 21, 2014
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4WSL
| Crystal structure of designed cPPR-polyC protein | Descriptor: | Pentatricopeptide repeat protein | Authors: | Coquille, S.C, Filipovska, A, Chia, T.S, Rajappa, L, Lingford, J.P, Razif, M.F.M, Thore, S, Rackham, O. | Deposit date: | 2014-10-28 | Release date: | 2014-12-24 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (3.7 Å) | Cite: | An artificial PPR scaffold for programmable RNA recognition. Nat Commun, 5, 2014
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1EMD
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1R5Y
| Crystal Structure of TGT in complex with 2,6-Diamino-3H-Quinazolin-4-one Crystallized at PH 5.5 | Descriptor: | 2,6-DIAMINO-3H-QUINAZOLIN-4-ONE, Queuine tRNA-ribosyltransferase, ZINC ION | Authors: | Brenk, R, Meyer, E, Reuter, K, Garcia, G.A, Stubbs, M.T, Klebe, G. | Deposit date: | 2003-10-13 | Release date: | 2004-04-13 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.2 Å) | Cite: | Crystallographic Study of Inhibitors of tRNA-guanine Transglycosylase Suggests a New Structure-based Pharmacophore for Virtual Screening. J.Mol.Biol., 338, 2004
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7PCR
| Helicobacter pylori RNase J | Descriptor: | Ribonuclease J | Authors: | Luisi, B.F, Pei, X.Y. | Deposit date: | 2021-08-03 | Release date: | 2022-05-25 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.75 Å) | Cite: | Acetylation regulates the oligomerization state and activity of RNase J, the Helicobacter pylori major ribonuclease. Nat Commun, 14, 2023
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7YND
| Cryo-EM structure of Cas7-11-crRNA-Csx29 ternary complex | Descriptor: | CHAT domain-containing protein, CRISPR-associated RAMP family protein, crRNA (38-MER) | Authors: | Huo, Y, Dong, Q, Zhao, H, Jiang, T. | Deposit date: | 2022-07-30 | Release date: | 2023-02-01 | Last modified: | 2023-03-15 | Method: | ELECTRON MICROSCOPY (3.29 Å) | Cite: | Cryo-EM structure and protease activity of the type III-E CRISPR-Cas effector. Nat Microbiol, 8, 2023
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6PLN
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6YLT
| Translation initiation factor 4E in complex with 3-MeBn7GpppG mRNA 5' cap analog | Descriptor: | Eukaryotic translation initiation factor 4E, [[(2~{R},3~{S},4~{R},5~{R})-5-[2-azanyl-7-[(3-methylphenyl)methyl]-6-oxidanylidene-1~{H}-purin-9-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [[(2~{R},3~{S},4~{R},5~{R})-5-(2-azanyl-6-oxidanylidene-1~{H}-purin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] hydrogen phosphate | Authors: | Kubacka, D, Wojcik, R, Baranowski, M.R, Kowalska, J, Jemielity, J. | Deposit date: | 2020-04-07 | Release date: | 2020-04-29 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.67 Å) | Cite: | Novel N7-Arylmethyl Substituted Dinucleotide mRNA 5' cap Analogs: Synthesis and Evaluation as Modulators of Translation. Pharmaceutics, 13, 2021
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5FVC
| Structure of RNA-bound decameric HMPV nucleoprotein | Descriptor: | HMPV NUCLEOPROTEIN, RNA | Authors: | Renner, M, Bertinelli, M, Leyrat, C, Paesen, G.C, Saraiva de Oliveira, L.F, Huiskonen, J.T, Grimes, J.M. | Deposit date: | 2016-02-05 | Release date: | 2016-02-24 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (4.17 Å) | Cite: | Nucleocapsid assembly in pneumoviruses is regulated by conformational switching of the N protein. Elife, 5, 2016
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5XMA
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2IS3
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8K34
| Cryo-EM structure of SPARTA gRNA binary complex | Descriptor: | MAGNESIUM ION, Piwi domain-containing protein, RNA (5'-R(P*AP*AP*AP*CP*GP*GP*CP*UP*CP*UP*AP*AP*UP*CP*UP*AP*UP*UP*AP*GP*U)-3'), ... | Authors: | Zhang, J.T, Jia, N. | Deposit date: | 2023-07-14 | Release date: | 2024-01-17 | Last modified: | 2024-04-10 | Method: | ELECTRON MICROSCOPY (2.81 Å) | Cite: | Target ssDNA activates the NADase activity of prokaryotic SPARTA immune system. Nat.Chem.Biol., 20, 2024
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8E5P
| Escherichia coli Rho-dependent transcription pre-termination complex containing 24 nt long RNA spacer, Mg-ADP-BeF3, and NusG; Rho hexamer part | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, MAGNESIUM ION, ... | Authors: | Molodtsov, V, Wang, C. | Deposit date: | 2022-08-22 | Release date: | 2022-09-07 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (4.4 Å) | Cite: | Structural basis of Rho-dependent transcription termination. Nature, 614, 2023
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8E6W
| Escherichia coli Rho-dependent transcription pre-termination complex containing 18 nt long RNA spacer, lambda-tR1 rut RNA, Mg-ADP-BeF3, and NusG; Rho part | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, MAGNESIUM ION, ... | Authors: | Molodtsov, V, Wang, C, Ebright, R.H. | Deposit date: | 2022-08-23 | Release date: | 2022-09-07 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (4.27 Å) | Cite: | Structural basis of Rho-dependent transcription termination. Nature, 614, 2023
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8E70
| Escherichia coli Rho-dependent transcription pre-termination complex containing 18 nt long RNA spacer, dC75 rut mimic RNA, Mg-ADP-BeF3, and NusG; Rho hexamer part | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, MAGNESIUM ION, ... | Authors: | Molodtsov, V, Wang, C, Ebright, R.H. | Deposit date: | 2022-08-23 | Release date: | 2022-09-07 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (4.1 Å) | Cite: | Structural basis of Rho-dependent transcription termination. Nature, 614, 2023
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3THT
| Crystal structure and RNA binding properties of the RRM/AlkB domains in human ABH8, an enzyme catalyzing tRNA hypermodification, Northeast Structural Genomics Consortium Target HR5601B | Descriptor: | 2-OXOGLUTARIC ACID, Alkylated DNA repair protein alkB homolog 8, MANGANESE (II) ION, ... | Authors: | Pastore, C, Topalidou, I, Forouhar, F, Yan, A.C, Levy, M, Hunt, J.F, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2011-08-19 | Release date: | 2011-11-02 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (3.01 Å) | Cite: | Crystal structure and RNA binding properties of the RNA recognition motif (RRM) and AlkB domains in human AlkB homolog 8 (ABH8), an enzyme catalyzing tRNA hypermodification. J.Biol.Chem., 287, 2012
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7RGS
| The crystal structure of RocC, containing FinO domain, 24-126 | Descriptor: | Repressor of competence, RNA Chaperone | Authors: | Kim, H.J, Edwards, R.A, Glover, J.N.M. | Deposit date: | 2021-07-15 | Release date: | 2022-11-09 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structural basis for recognition of transcriptional terminator structures by ProQ/FinO domain RNA chaperones. Nat Commun, 13, 2022
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7RGT
| The crystal structure of RocC, containing FinO domain, 1-126 | Descriptor: | Repressor of competence, RNA Chaperone, SULFATE ION | Authors: | Kim, H.J, Edwards, R.A, Glover, J.N.M. | Deposit date: | 2021-07-15 | Release date: | 2022-11-09 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.02 Å) | Cite: | Structural basis for recognition of transcriptional terminator structures by ProQ/FinO domain RNA chaperones. Nat Commun, 13, 2022
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5H9E
| Crystal structure of E. coli Cascade bound to a PAM-containing dsDNA target (32-nt spacer) at 3.20 angstrom resolution. | Descriptor: | CRISPR system Cascade subunit CasA, CRISPR system Cascade subunit CasB, CRISPR system Cascade subunit CasC, ... | Authors: | Hayes, R.P, Xiao, Y, Ding, F, van Erp, P.B.G, Rajashankar, K, Bailey, S, Wiedenheft, B, Ke, A. | Deposit date: | 2015-12-28 | Release date: | 2016-02-17 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (3.21 Å) | Cite: | Structural basis for promiscuous PAM recognition in type I-E Cascade from E. coli. Nature, 530, 2016
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5H9F
| Crystal structure of E. coli Cascade bound to a PAM-containing dsDNA target at 2.45 angstrom resolution. | Descriptor: | CRISPR system Cascade subunit CasA, CRISPR system Cascade subunit CasB, CRISPR system Cascade subunit CasC, ... | Authors: | Hayes, R.P, Xiao, Y, Ding, F, van Erp, P.B.G, Rajashankar, K, Bailey, S, Wiedenheft, B, Ke, A. | Deposit date: | 2015-12-28 | Release date: | 2016-02-17 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.45 Å) | Cite: | Structural basis for promiscuous PAM recognition in type I-E Cascade from E. coli. Nature, 530, 2016
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2FFL
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3THP
| Crystal structure and RNA binding properties of the RRM/AlkB domains in human ABH8, an enzyme catalyzing tRNA hypermodification, Northeast Structural Genomics Consortium Target HR5601B | Descriptor: | 2-OXOGLUTARIC ACID, Alkylated DNA repair protein alkB homolog 8, MANGANESE (II) ION, ... | Authors: | Pastore, C, Topalidou, I, Forouhar, F, Yan, A.C, Levy, M, Hunt, J.F, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2011-08-19 | Release date: | 2011-11-02 | Last modified: | 2023-12-06 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Crystal structure and RNA binding properties of the RNA recognition motif (RRM) and AlkB domains in human AlkB homolog 8 (ABH8), an enzyme catalyzing tRNA hypermodification. J.Biol.Chem., 287, 2012
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2FE9
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