Structure of HIV-1 reverse transcriptase in complex with an RNase H inhibitor and nevirapine

Summary for 3QIP
DescriptorReverse HIV-1 reverse transcriptase p66, p51, 11-CYCLOPROPYL-5,11-DIHYDRO-4-METHYL-6H-DIPYRIDO[3,2-B:2',3'-E][1,4]DIAZEPIN-6-ONE, ... (8 entities in total)
Functional Keywordshiv, reverse transcriptase, rnase h, polymerase, nuclease, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceHIV-1 M:B_HXB2R (HIV-1)
Cellular locationMatrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P04585 P04585
Total number of polymer chains2
Total formula weight116962.55
Lansdon, E.B.,Kirschberg, T.A. (deposition date: 2011-01-27, release date: 2011-04-20, Last modification date: 2011-07-13)
Primary citationBalakrishnan, M.,Kirschberg, T.A.,Kutty, N.,Lancaster-Moyer, C.,Lansdon, E.B.,Leavitt, S.A.,Liu, Q.,Liu, X.,Perry, J.K.,Squires, N.H.,Watkins, W.J.
Structural and Binding Analysis of Pyrimidinol Carboxylic Acid and N-Hydroxy Quinazolinedione HIV-1 RNase H Inhibitors.
Antimicrob.Agents Chemother., 55:2905-2915, 2011
PubMed: 21464257
DOI: 110.1128/AAC.01594-10
PDB entries with the same primary citation
Experimental method
Structure validation
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PDB entries from 2021-06-09