3QIP

Structure of HIV-1 reverse transcriptase in complex with an RNase H inhibitor and nevirapine

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Reverse HIV-1 reverse transcriptase p66	polymer	560	64562.9	1	UniProt (P04585) Pfam (PF00078) Pfam (PF06817) Pfam (PF06815) Pfam (PF00075) In PDB	HIV-1 M:B_HXB2R (HIV-1)	Pr160Gag-Pol, Matrix protein p17, MA, Capsid protein p24, CA, Spacer peptide p2, Nucleocapsid protein p7, NC, Transframe peptide, TF, p6-pol, p6*, Protease, PR, Retropepsin, Reverse transcriptase/ribonuclease H, p66 RT, p51 RT, p15, Integrase, IN
2	B	p51	polymer	440	51399.0	1	UniProt (P04585) Pfam (PF00078) Pfam (PF06817) Pfam (PF06815) In PDB	HIV-1 M:B_HXB2R (HIV-1)	Pr160Gag-Pol, Matrix protein p17, MA, Capsid protein p24, CA, Spacer peptide p2, Nucleocapsid protein p7, NC, Transframe peptide, TF, p6-pol, p6*, Protease, PR, Retropepsin, Reverse transcriptase/ribonuclease H, p66 RT, p51 RT, p15, Integrase, IN
3	A	11-CYCLOPROPYL-5,11-DIHYDRO-4-METHYL-6H-DIPYRIDO[3,2-B:2',3'-E][1,4]DIAZEPIN-6-ONE	non-polymer		266.3	1	Chemie (NVP)
4	A	MANGANESE (II) ION	non-polymer		54.9	2	Chemie (MN)
5	A	SULFATE ION	non-polymer		96.1	2	Chemie (SO4)
6	A, B	CHLORIDE ION	non-polymer		35.5	2	Chemie (CL)
7	A	5,6-dihydroxy-2-[(2-phenyl-1H-indol-3-yl)methyl]pyrimidine-4-carboxylic acid	non-polymer		361.4	1	Chemie (P4Y)
8		water	water		18.0	418	Chemie (HOH)

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	115962.0
Non-Polymers*	Number of molecules	8
	Total formula weight	1000.6
All*	Total formula weight	116962.6

*Water molecules are not included.