3THP

Crystal structure and RNA binding properties of the RRM/AlkB domains in human ABH8, an enzyme catalyzing tRNA hypermodification, Northeast Structural Genomics Consortium Target HR5601B

Summary for 3THP

• Entry DOI: 10.2210/pdb3thp/pdb
• Related: 3THT
• Descriptor: Alkylated DNA repair protein alkB homolog 8, ZINC ION, MANGANESE (II) ION, ... (4 entities in total)
• Functional Keywords: structural genomics, psi-biology, northeast structural genomics consortium, nesg, alpha-beta two domain-protein containing a zinc structure motif, trna modifying enzyme, oxidoreductase
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm : Q96BT7
• Total number of polymer chains: 1
• Total formula weight: 39954.39

Authors

Pastore, C.,Topalidou, I.,Forouhar, F.,Yan, A.C.,Levy, M.,Hunt, J.F.,Northeast Structural Genomics Consortium (NESG) (deposition date: 2011-08-19, release date: 2011-11-02, Last modification date: 2023-12-06)

• Primary citation: Pastore, C.,Topalidou, I.,Forouhar, F.,Yan, A.C.,Levy, M.,Hunt, J.F.; Crystal structure and RNA binding properties of the RNA recognition motif (RRM) and AlkB domains in human AlkB homolog 8 (ABH8), an enzyme catalyzing tRNA hypermodification.; J.Biol.Chem., 287:2130-2143, 2012; PubMed: 22065580; DOI: 10.1074/jbc.M111.286187

Experimental method

X-RAY DIFFRACTION (3.2 Å)