3THP

Crystal structure and RNA binding properties of the RRM/AlkB domains in human ABH8, an enzyme catalyzing tRNA hypermodification, Northeast Structural Genomics Consortium Target HR5601B

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003676	molecular_function	nucleic acid binding
A	0003723	molecular_function	RNA binding
A	0070988	biological_process	demethylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 401

Chain	Residue
A	HIS242
A	CYS341
A	CYS343
A	CYS349

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site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MN A 402

Chain	Residue
A	HIS238
A	ASP240
A	HIS292
A	AKG403

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site_id	AC3
Number of Residues	11
Details	BINDING SITE FOR RESIDUE AKG A 403

Chain	Residue
A	TYR229
A	HIS238
A	SER251
A	MSE260
A	HIS292
A	ARG328
A	SER330
A	THR332
A	ARG334
A	MN402
A	ASN227

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Functional Information from PROSITE/UniProt

site_id	PS00050
Number of Residues	16
Details	RIBOSOMAL_L23 Ribosomal protein L23 signature. KRAYVTLNgkevvddL

Chain	Residue	Details
A	LYS94-LEU109

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	7
Details	BINDING: BINDING => ECO:0000269|PubMed:22065580

Chain	Residue	Details
A	ASN227
A	HIS242
A	ARG328
A	ARG334
A	CYS341
A	CYS343
A	CYS349

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site_id	SWS_FT_FI2
Number of Residues	3
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00805, ECO:0000305

Chain	Residue	Details
A	HIS238
A	ASP240
A	HIS292

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