PDB: 52540 resultsInfo pagesStatus searchChemie searchBIRD

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8WUW	Cryo-EM structure of H. thermophilus GroEL-GroES2 asymmetric football complex Descriptor: Chaperonin GroEL, Co-chaperonin GroES, MAGNESIUM ION, ... Authors: Liao, Z, Gopalasingam, C.C, Kameya, M, Gerle, C, Shigematsu, H, Ishii, M, Arakawa, T, Fushinobu, S. Deposit date: 2023-10-21 Release date: 2024-03-27 Last modified: 2024-06-19 Method: ELECTRON MICROSCOPY (2.6 Å) Cite: Structural insights into thermophilic chaperonin complexes. Structure, 32, 2024
9BC7	HCN1 M305L holo Descriptor: 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 Authors: Kim, E.D, Nimigean, C.M. Deposit date: 2024-04-08 Release date: 2024-07-31 Last modified: 2024-08-21 Method: ELECTRON MICROSCOPY (3.3 Å) Cite: Propofol rescues voltage-dependent gating of HCN1 channel epilepsy mutants. Nature, 632, 2024
3QI4	Crystal structure of PDE9A(Q453E) in complex with IBMX Descriptor: 3-ISOBUTYL-1-METHYLXANTHINE, High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A, MAGNESIUM ION, ... Authors: Hou, J, Xu, J, Liu, M, Zhao, R, Lou, H, Ke, H. Deposit date: 2011-01-26 Release date: 2011-04-27 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Structural asymmetry of phosphodiesterase-9, potential protonation of a glutamic Acid, and role of the invariant glutamine. Plos One, 6, 2011
1O3R	PROTEIN-DNA RECOGNITION AND DNA DEFORMATION REVEALED IN CRYSTAL STRUCTURES OF CAP-DNA COMPLEXES Descriptor: 5'-D(*AP*AP*AP*AP*AP*TP*GP*CP*GP*AP*T)-3', 5'-D(*CP*TP*AP*GP*AP*TP*CP*GP*CP*AP*TP*TP*TP*TP*T)-3', ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, ... Authors: Chen, S, Vojtechovsky, J, Parkinson, G.N, Ebright, R.H, Berman, H.M. Deposit date: 2003-03-18 Release date: 2003-04-08 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (3 Å) Cite: Indirect Readout of DNA Sequence at the Primary-kink Site in the CAP-DNA Complex: DNA Binding Specificity Based on Energetics of DNA Kinking J.Mol.Biol., 314, 2001
1O3Q	PROTEIN-DNA RECOGNITION AND DNA DEFORMATION REVEALED IN CRYSTAL STRUCTURES OF CAP-DNA COMPLEXES Descriptor: 5'-D(*AP*AP*AP*AP*AP*TP*GP*TP*GP*AP*T)-3', 5'-D(*CP*TP*AP*GP*AP*TP*CP*AP*CP*AP*TP*TP*TP*TP*T)-3', ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, ... Authors: Chen, S, Vojtechovsky, J, Parkinson, G.N, Ebright, R.H, Berman, H.M. Deposit date: 2003-03-18 Release date: 2003-04-08 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (3 Å) Cite: Indirect Readout of DNA Sequence at the Primary-kink Site in the CAP-DNA Complex: DNA Binding Specificity Based on Energetics of DNA Kinking J.Mol.Biol., 314, 2001
1O3T	PROTEIN-DNA RECOGNITION AND DNA DEFORMATION REVEALED IN CRYSTAL STRUCTURES OF CAP-DNA COMPLEXES Descriptor: 5'-D(*CP*TP*AP*GP*AP*TP*CP*GP*CP*AP*TP*TP*TP*TP*TP*CP*G)-3', 5'-D(*GP*CP*GP*AP*AP*AP*AP*AP*TP*GP*CP*GP*AP*T)-3', ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, ... Authors: Chen, S, Vojtechovsky, J, Parkinson, G.N, Ebright, R.H, Berman, H.M. Deposit date: 2003-03-18 Release date: 2003-04-08 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Indirect Readout of DNA Sequence at the Primary-kink Site in the CAP-DNA Complex: DNA Binding Specificity Based on Energetics of DNA Kinking J.Mol.Biol., 314, 2001
7BPB	Human AAA+ ATPase VCP mutant - T76E, AMP-PNP bound form, Conformation I Descriptor: ADENOSINE-5'-DIPHOSPHATE, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Transitional endoplasmic reticulum ATPase Authors: Yang, C, Zhang, H. Deposit date: 2020-03-22 Release date: 2021-03-31 Last modified: 2022-04-27 Method: ELECTRON MICROSCOPY (4.3 Å) Cite: The phosphorylation and dephosphorylation switch of VCP/p97 regulates the architecture of centrosome and spindle. Cell Death Differ., 2022
7BPA	Human AAA+ ATPase VCP mutant - T76A, AMP-PNP-bound form, Conformation I Descriptor: ADENOSINE-5'-DIPHOSPHATE, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Transitional endoplasmic reticulum ATPase Authors: Yang, C, Zhang, H. Deposit date: 2020-03-21 Release date: 2021-03-31 Last modified: 2022-04-27 Method: ELECTRON MICROSCOPY (3.3 Å) Cite: The phosphorylation and dephosphorylation switch of VCP/p97 regulates the architecture of centrosome and spindle. Cell Death Differ., 2022
1O3S	PROTEIN-DNA RECOGNITION AND DNA DEFORMATION REVEALED IN CRYSTAL STRUCTURES OF CAP-DNA COMPLEXES Descriptor: 5'-D(*AP*AP*AP*AP*AP*TP*GP*CP*GP*AP*T)-3', 5'-D(*CP*TP*AP*GP*AP*TP*CP*GP*CP*AP*TP*TP*TP*TP*T)-3', ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, ... Authors: Chen, S, Ebright, R.H, Berman, H.M. Deposit date: 2003-03-18 Release date: 2003-04-08 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (3 Å) Cite: Indirect Readout of DNA Sequence at the Primary-kink Site in the CAP-DNA Complex: Alteration of DNA Binding Specificity Through Alteration of DNA Kinking J.Mol.Biol., 314, 2001
3L2P	Human DNA Ligase III Recognizes DNA Ends by Dynamic Switching Between Two DNA Bound States Descriptor: 5'-D(*GP*CP*CP*AP*GP*TP*CP*CP*GP*AP*CP*GP*AP*CP*GP*CP*AP*TP*CP*CP*CP*G)-3', 5'-D(*GP*TP*CP*GP*GP*AP*CP*TP*G)-3', 5'-D(P*CP*GP*GP*GP*AP*TP*GP*CP*GP*TP*C)-3', ... Authors: Cotner-Gohara, E.A, Kim, I.K, Hammel, M, Tainer, J.A, Tomkinson, A, Ellenberger, T. Deposit date: 2009-12-15 Release date: 2010-07-14 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (3 Å) Cite: Human DNA Ligase III Recognizes DNA Ends by Dynamic Switching between Two DNA-Bound States. Biochemistry, 49, 2010
3QI3	Crystal structure of PDE9A(Q453E) in complex with inhibitor BAY73-6691 Descriptor: 1-(2-chlorophenyl)-6-[(2R)-3,3,3-trifluoro-2-methylpropyl]-1,7-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one, High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A, MAGNESIUM ION, ... Authors: Hou, J, Xu, J, Liu, M, Zhao, R, Lou, H, Ke, H. Deposit date: 2011-01-26 Release date: 2011-04-27 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Structural asymmetry of phosphodiesterase-9, potential protonation of a glutamic Acid, and role of the invariant glutamine. Plos One, 6, 2011
2GXU	HERA N-terminal domain in complex with orthophosphate, crystal form 1 Descriptor: PHOSPHATE ION, heat resistant RNA dependent ATPase Authors: Rudolph, M.G, Klostermeier, D. Deposit date: 2006-05-09 Release date: 2006-08-22 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (1.67 Å) Cite: Crystal Structure and Nucleotide Binding of the Thermus thermophilus RNA Helicase Hera N-terminal Domain. J.Mol.Biol., 351, 2006
1IVQ	THE CRYSTALLOGRAPHIC STRUCTURE OF THE PROTEASE FROM HUMAN IMMUNODEFICIENCY VIRUS TYPE 2 WITH TWO SYNTHETIC PEPTIDIC TRANSITION STATE ANALOG INHIBITORS Descriptor: HIV-2 PROTEASE, N~1~-{(1S,2S,4S)-1-(cyclohexylmethyl)-4-[(2,2-dimethylpropyl)carbamoyl]-2-hydroxy-5-methylhexyl}-N~2~-(quinolin-2-ylcar bonyl)-L-aspartamide Authors: Mulichak, A.M, Watenpaugh, K.D. Deposit date: 1993-03-18 Release date: 1993-07-15 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2.6 Å) Cite: The crystallographic structure of the protease from human immunodeficiency virus type 2 with two synthetic peptidic transition state analog inhibitors. J.Biol.Chem., 268, 1993
7B5W	RCK_C domain of S.agalactiae BusR in ligand-free state Descriptor: GntR family transcriptional regulator Authors: Bandera, A.M, Witte, G. Deposit date: 2020-12-07 Release date: 2021-08-11 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1 Å) Cite: BusR senses bipartite DNA binding motifs by a unique molecular ruler architecture. Nucleic Acids Res., 49, 2021
3IES	Firefly luciferase inhibitor complex Descriptor: 5'-O-[(R)-[({3-[5-(2-fluorophenyl)-1,2,4-oxadiazol-3-yl]phenyl}carbonyl)oxy](hydroxy)phosphoryl]adenosine, Luciferin 4-monooxygenase Authors: Lovell, S, Battaile, K.P, Auld, D.S, Thorne, N, Lea, W.A, Maloney, D.J, Shen, M, Raj, G, Thomas, C.J, Simeonov, A, Hanzlik, R.P, Inglese, J. Deposit date: 2009-07-23 Release date: 2010-02-16 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2 Å) Cite: Molecular basis for the high-affinity binding and stabilization of firefly luciferase by PTC124. Proc.Natl.Acad.Sci.USA, 107, 2010
3IER	Firefly luciferase apo structure (P41 form) with PEG 400 bound Descriptor: Luciferin 4-monooxygenase, TETRAETHYLENE GLYCOL Authors: Lovell, S, Battaile, K.P, Auld, D.S, Thorne, N, Lea, W.A, Maloney, D.J, Shen, M, Raj, G, Thomas, C.J, Simeonov, A, Hanzlik, R.P, Inglese, J. Deposit date: 2009-07-23 Release date: 2010-02-16 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.05 Å) Cite: Molecular basis for the high-affinity binding and stabilization of firefly luciferase by PTC124. Proc.Natl.Acad.Sci.USA, 107, 2010
3IEP	Firefly luciferase apo structure (P41 form) Descriptor: Luciferin 4-monooxygenase Authors: Lovell, S, Battaile, K.P, Auld, D.S, Thorne, N, Lea, W.A, Maloney, D.J, Shen, M, Raj, G, Thomas, C.J, Simeonov, A, Hanzlik, R.P, Inglese, J. Deposit date: 2009-07-23 Release date: 2010-02-16 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Molecular basis for the high-affinity binding and stabilization of firefly luciferase by PTC124. Proc.Natl.Acad.Sci.USA, 107, 2010
1ABB	CONTROL OF PHOSPHORYLASE B CONFORMATION BY A MODIFIED COFACTOR: CRYSTALLOGRAPHIC STUDIES ON R-STATE GLYCOGEN PHOSPHORYLASE RECONSTITUTED WITH PYRIDOXAL 5'-DIPHOSPHATE Descriptor: GLYCOGEN PHOSPHORYLASE B, INOSINIC ACID, PYRIDOXAL-5'-DIPHOSPHATE, ... Authors: Leonidas, D.D, Oikonomakos, N.G, Papageorgiou, A.C, Acharya, K.R, Barford, D, Johnson, L.N. Deposit date: 1992-04-09 Release date: 1993-10-31 Last modified: 2024-06-05 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Control of phosphorylase b conformation by a modified cofactor: crystallographic studies on R-state glycogen phosphorylase reconstituted with pyridoxal 5'-diphosphate. Protein Sci., 1, 1992
1C1Y	CRYSTAL STRUCTURE OF RAP.GMPPNP IN COMPLEX WITH THE RAS-BINDING-DOMAIN OF C-RAF1 KINASE (RAFRBD). Descriptor: CALCIUM ION, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... Authors: Nassar, N. Deposit date: 1999-07-22 Release date: 1999-08-02 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.9 Å) Cite: The 2.2 A crystal structure of the Ras-binding domain of the serine/threonine kinase c-Raf1 in complex with Rap1A and a GTP analogue. Nature, 375, 1995
4S34	ERK2 (I84A) in complex with AMP-PNP Descriptor: MAGNESIUM ION, Mitogen-activated protein kinase 1, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... Authors: Livnah, O, Karamansha, Y, Tzarum, N. Deposit date: 2015-01-26 Release date: 2016-01-27 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Multiple mechanisms render Erk proteins MEK-independent To be Published
4S33	ERK2 R65S mutant complexed with AMP-PNP Descriptor: MAGNESIUM ION, Mitogen-activated protein kinase 1, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... Authors: Livnah, O, Karamansha, Y, Tzarum, N. Deposit date: 2015-01-26 Release date: 2016-01-27 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.48 Å) Cite: Multiple mechanisms render Erk proteins MEK-independent To be Published
9ILD	Complex structure of Cap3 and CD-NTase Descriptor: Cyclic GMP-AMP synthase, Peptidase, ZINC ION Authors: Li, F.Q, Ma, W.F. Deposit date: 2024-06-29 Release date: 2024-07-31 Method: X-RAY DIFFRACTION (2.179 Å) Cite: Structural and functional characterization of the bacterial Cap3 enzyme in deconjugation and regulation of the cyclic dinucleotide transferase CD-NTase To Be Published
5YW5	Crystal structure of Adenine phosphoribosyltransferase from Francisella tularensis in complex with adenine Descriptor: ADENINE, Adenine phosphoribosyltransferase Authors: Pavithra, G.C, Ramagopal, U.A. Deposit date: 2017-11-28 Release date: 2018-01-03 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Crystal structures of APRT from Francisella tularensis - an N-H···N hydrogen bond imparts adenine specificity in adenine phosporibosyltransferases. FEBS J., 285, 2018
5YW2	Crystal structure of Adenine phosphoribosyltransferase from Francisella tularensis. Descriptor: Adenine phosphoribosyltransferase, CHLORIDE ION, MAGNESIUM ION, ... Authors: Pavithra, G.C, Ramagopal, U.A. Deposit date: 2017-11-28 Release date: 2018-01-03 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2.28 Å) Cite: Crystal structures of APRT from Francisella tularensis - an N-H···N hydrogen bond imparts adenine specificity in adenine phosporibosyltransferases. FEBS J., 285, 2018
2GPA	ALLOSTERIC INHIBITION OF GLYCOGEN PHOSPHORYLASE A BY A POTENTIAL ANTIDIABETIC DRUG Descriptor: GLYCEROL, PROTEIN (GLYCOGEN PHOSPHORYLASE), PYRIDOXAL-5'-PHOSPHATE, ... Authors: Oikonomakos, N.G, Tsitsanou, K.E, Zographos, S.E, Skamnaki, V.T. Deposit date: 1999-02-18 Release date: 1999-02-26 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (2 Å) Cite: Allosteric inhibition of glycogen phosphorylase a by the potential antidiabetic drug 3-isopropyl 4-(2-chlorophenyl)-1,4-dihydro-1-ethyl-2-methyl-pyridine-3,5,6-tricarbo xylate. Protein Sci., 8, 1999

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