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3IES

Firefly luciferase inhibitor complex

Summary for 3IES
Entry DOI10.2210/pdb3ies/pdb
Related3IEP 3IER
DescriptorLuciferin 4-monooxygenase, 5'-O-[(R)-[({3-[5-(2-fluorophenyl)-1,2,4-oxadiazol-3-yl]phenyl}carbonyl)oxy](hydroxy)phosphoryl]adenosine (3 entities in total)
Functional Keywordsoxidoreductase, monooxygenase, photoprotein, luminescence, atp-binding, magnesium, metal-binding, nucleotide-binding, peroxisome
Biological sourcePhotinus pyralis (North American firefly)
Cellular locationPeroxisome : P08659
Total number of polymer chains1
Total formula weight61531.53
Authors
Lovell, S.,Battaile, K.P.,Auld, D.S.,Thorne, N.,Lea, W.A.,Maloney, D.J.,Shen, M.,Raj, G.,Thomas, C.J.,Simeonov, A.,Hanzlik, R.P.,Inglese, J. (deposition date: 2009-07-23, release date: 2010-02-16, Last modification date: 2023-09-06)
Primary citationAuld, D.S.,Lovell, S.,Thorne, N.,Lea, W.A.,Maloney, D.J.,Shen, M.,Rai, G.,Battaile, K.P.,Thomas, C.J.,Simeonov, A.,Hanzlik, R.P.,Inglese, J.
Molecular basis for the high-affinity binding and stabilization of firefly luciferase by PTC124.
Proc.Natl.Acad.Sci.USA, 107:4878-4883, 2010
Cited by
PubMed: 20194791
DOI: 10.1073/pnas.0909141107
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2 Å)
Structure validation

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