1IVQ

THE CRYSTALLOGRAPHIC STRUCTURE OF THE PROTEASE FROM HUMAN IMMUNODEFICIENCY VIRUS TYPE 2 WITH TWO SYNTHETIC PEPTIDIC TRANSITION STATE ANALOG INHIBITORS

Summary for 1IVQ

• Entry DOI: 10.2210/pdb1ivq/pdb
• Related: 1IVP
• Related PRD ID: PRD_000348
• Descriptor: HIV-2 PROTEASE, N~1~-{(1S,2S,4S)-1-(cyclohexylmethyl)-4-[(2,2-dimethylpropyl)carbamoyl]-2-hydroxy-5-methylhexyl}-N~2~-(quinolin-2-ylcar bonyl)-L-aspartamide (3 entities in total)
• Functional Keywords: acid proteinase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Human immunodeficiency virus 2
• Cellular location: Gag-Pol polyprotein: Host cell membrane; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P04584
• Total number of polymer chains: 2
• Total formula weight: 22034.43

Authors

Mulichak, A.M.,Watenpaugh, K.D. (deposition date: 1993-03-18, release date: 1993-07-15, Last modification date: 2024-02-07)

• Primary citation: Mulichak, A.M.,Hui, J.O.,Tomasselli, A.G.,Heinrikson, R.L.,Curry, K.A.,Tomich, C.S.,Thaisrivongs, S.,Sawyer, T.K.,Watenpaugh, K.D.; The crystallographic structure of the protease from human immunodeficiency virus type 2 with two synthetic peptidic transition state analog inhibitors.; J.Biol.Chem., 268:13103-13109, 1993; PubMed: 8514751

Experimental method

X-RAY DIFFRACTION (2.6 Å)