2GPA

ALLOSTERIC INHIBITION OF GLYCOGEN PHOSPHORYLASE A BY A POTENTIAL ANTIDIABETIC DRUG

Summary for 2GPA

• Entry DOI: 10.2210/pdb2gpa/pdb
• Descriptor: PROTEIN (GLYCOGEN PHOSPHORYLASE), alpha-D-glucopyranose, PYRIDOXAL-5'-PHOSPHATE, ... (5 entities in total)
• Functional Keywords: diabetes, glycogen metabolism, phosphorylase a, inhibition, allosteric site, transferase
• Biological source: Oryctolagus cuniculus (rabbit)
• Total number of polymer chains: 1
• Total formula weight: 97890.57

Authors

Oikonomakos, N.G.,Tsitsanou, K.E.,Zographos, S.E.,Skamnaki, V.T. (deposition date: 1999-02-18, release date: 1999-02-26, Last modification date: 2023-12-27)

• Primary citation: Oikonomakos, N.G.,Tsitsanou, K.E.,Zographos, S.E.,Skamnaki, V.T.,Goldmann, S.,Bischoff, H.; Allosteric inhibition of glycogen phosphorylase a by the potential antidiabetic drug 3-isopropyl 4-(2-chlorophenyl)-1,4-dihydro-1-ethyl-2-methyl-pyridine-3,5,6-tricarbo xylate.; Protein Sci., 8:1930-1945, 1999; PubMed: 10548038

Experimental method

X-RAY DIFFRACTION (2 Å)