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7G1Y	Crystal Structure of human FABP4 in complex with 2-[(3-methoxyphenyl)sulfanylmethyl]-1,3-thiazole-4-carboxylic acid Descriptor: 2-{[(3-methoxyphenyl)sulfanyl]methyl}-1,3-thiazole-4-carboxylic acid, FORMIC ACID, Fatty acid-binding protein, ... Authors: Ehler, A, Benz, J, Obst, U, Grenz-Achim, K, Rudolph, M.G. Deposit date: 2023-04-27 Release date: 2023-06-14 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (0.95 Å) Cite: Crystal Structure of a human FABP4 complex To be published
7G0C	Crystal Structure of human FABP4 binding site mutated to that of FABP5 in complex with 2-[2,3-bis[(2-chlorophenyl)methoxy]phenyl]-2-methoxyacetic acid Descriptor: (2R)-{2,3-bis[(2-chlorophenyl)methoxy]phenyl}(methoxy)acetic acid, Fatty acid-binding protein, adipocyte Authors: Ehler, A, Benz, J, Obst, U, Obst-Sander, U, Rudolph, M.G. Deposit date: 2023-04-27 Release date: 2023-06-14 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (1.14 Å) Cite: Crystal Structure of a human FABP4 binding site mutated to that of FABP5 complex To be published
7JX2	Cellular retinol-binding protein 2 (CRBP2) in complex with 2-palmitoylglycerol Descriptor: 1,3-dihydroxypropan-2-yl hexadecanoate, Retinol-binding protein 2 Authors: Silvaroli, J.A, Banarjee, S, Golczak, M. Deposit date: 2020-08-26 Release date: 2021-03-10 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Molecular basis for the interaction of cellular retinol binding protein 2 (CRBP2) with nonretinoid ligands. J.Lipid Res., 62, 2021
7JWR	Cellular retinol-binding protein 2 (CRBP2) in complex with 2-oleoylglycerol Descriptor: 1,3-dihydroxypropan-2-yl (9Z)-octadec-9-enoate, Retinol-binding protein 2 Authors: Silvaroli, J.A, Banarjee, S, Golczak, M. Deposit date: 2020-08-26 Release date: 2021-03-10 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.30000067 Å) Cite: Molecular basis for the interaction of cellular retinol binding protein 2 (CRBP2) with nonretinoid ligands. J.Lipid Res., 62, 2021
7JVG	Cellular retinol-binding protein 2 (CRBP2) in complex with 1-arachidonoylglycerol Descriptor: (2S)-2,3-dihydroxypropyl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate, Retinol-binding protein 2 Authors: Silvaroli, J.A, Golczak, M. Deposit date: 2020-08-21 Release date: 2021-03-10 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.4 Å) Cite: Molecular basis for the interaction of cellular retinol binding protein 2 (CRBP2) with nonretinoid ligands. J.Lipid Res., 62, 2021
7JVY	Cellular retinol-binding protein 2 (CRBP2) in complex with 2-arachidonylglyceryl ether Descriptor: 2-{[(5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraen-1-yl]oxy}propane-1,3-diol, Retinol-binding protein 2 Authors: Silvaroli, J.A, Banarjee, S, Golczak, M. Deposit date: 2020-08-24 Release date: 2021-03-10 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.3 Å) Cite: Molecular basis for the interaction of cellular retinol binding protein 2 (CRBP2) with nonretinoid ligands. J.Lipid Res., 62, 2021
7JWD	Cellular retinol-binding protein 2 (CRBP2) in complex with 2-linoleoylglycerol Descriptor: 1,3-dihydroxypropan-2-yl (9Z,12Z)-octadeca-9,12-dienoate, Retinol-binding protein 2 Authors: Silvaroli, J.A, Banarjee, S, Golczak, M. Deposit date: 2020-08-25 Release date: 2021-03-10 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.35000193 Å) Cite: Molecular basis for the interaction of cellular retinol binding protein 2 (CRBP2) with nonretinoid ligands. J.Lipid Res., 62, 2021
7K3I	Cellular retinol-binding protein 2 (CRBP2) in complex with 2-lauroylglycerol Descriptor: 1,3-dihydroxypropan-2-yl dodecanoate, Retinol-binding protein 2 Authors: Adams, C, Silvaroli, J.A, Banarjee, S, Golczak, M. Deposit date: 2020-09-11 Release date: 2021-03-10 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.2 Å) Cite: Molecular basis for the interaction of cellular retinol binding protein 2 (CRBP2) with nonretinoid ligands. J.Lipid Res., 62, 2021
7JZ5	Cellular retinol-binding protein 2 (CRBP2) in complex with 1-arachodonoyl-1-thio-glycerol Descriptor: Retinol-binding protein 2, S-[(2R)-2,3-dihydroxypropyl] (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenethioate Authors: Silvaroli, J.A, Banarjee, S, Golczak, M. Deposit date: 2020-09-01 Release date: 2021-03-10 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.567 Å) Cite: Molecular basis for the interaction of cellular retinol binding protein 2 (CRBP2) with nonretinoid ligands. J.Lipid Res., 62, 2021
7KOT	Energetic and structural effects of the Tanford transition on the ligand recognition of bovine Beta-lactoglobulin Descriptor: Beta-lactoglobulin, DODECYL SULFATE Authors: Rodriguez-Hernandez, A, Rodriguez-Romero, A. Deposit date: 2020-11-09 Release date: 2021-01-27 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.74 Å) Cite: Energetic and structural effects of the Tanford transition on ligand recognition of bovine beta-lactoglobulin. Arch.Biochem.Biophys., 699, 2021
4MVL	Crystal structure of an engineered lipocalin (Anticalin H1GA) in complex with the Alzheimer amyloid peptide Abeta1-40 Descriptor: Beta-amyloid protein 40, Neutrophil gelatinase-associated lipocalin Authors: Eichinger, A, Skerra, A. Deposit date: 2013-09-24 Release date: 2015-08-12 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.3 Å) Cite: High-affinity Anticalins with aggregation-blocking activity directed against the Alzheimer beta-amyloid peptide. Biochem.J., 473, 2016
1QAB	The structure of human retinol binding protein with its carrier protein transthyretin reveals interaction with the carboxy terminus of RBP Descriptor: PROTEIN (retinol binding protein), PROTEIN (transthyretin), RETINOL Authors: Naylor, H.M, Newcomer, M.E. Deposit date: 1999-02-03 Release date: 1999-02-16 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (3.2 Å) Cite: The structure of human retinol-binding protein (RBP) with its carrier protein transthyretin reveals an interaction with the carboxy terminus of RBP. Biochemistry, 38, 1999
6SUA	Structure of the high affinity engineered lipocalin C1B12 in complex with the mouse CD98 heavy chain ectodomain Descriptor: 4F2 cell-surface antigen heavy chain, Neutrophil gelatinase-associated lipocalin, SULFATE ION Authors: Schiefner, A, Deuschle, F.-C, Skerra, A. Deposit date: 2019-09-13 Release date: 2020-06-17 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2.75 Å) Cite: Design of a surrogate Anticalin protein directed against CD98hc for preclinical studies in mice. Protein Sci., 29, 2020
2WQA	Complex of TTR and RBP4 and Oleic Acid Descriptor: OLEIC ACID, RETINOL-BINDING PROTEIN 4, SULFATE ION, ... Authors: Nanao, M, Mercer, D, Nguyen, L, Buckley, D, Stout, T.J. Deposit date: 2009-08-14 Release date: 2010-09-01 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (2.85 Å) Cite: Crystal Structure of Rbp4 Bound to Linoleic Acid and Ttr To be Published
3BSZ	Crystal structure of the transthyretin-retinol binding protein-Fab complex Descriptor: Fab fragment heavy chain, Fab fragment light chain, Plasma retinol-binding protein, ... Authors: Zanotti, G, Cendron, L, Gliubich, F, Folli, C, Berni, R. Deposit date: 2007-12-27 Release date: 2008-11-11 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (3.38 Å) Cite: Structural and mutational analyses of protein-protein interactions between transthyretin and retinol-binding protein. Febs J., 275, 2008
6QBA	Crystal Structure of Retinol-Binding Protein 4 (RBP4) in complex with non-retinoid ligand A1120 and engineered binding scaffold Descriptor: 2-[({4-[2-(trifluoromethyl)phenyl]piperidin-1-yl}carbonyl)amino]benzoic acid, ACETATE ION, DI(HYDROXYETHYL)ETHER, ... Authors: Mlynek, G, Brey, C.U, Djinovic-Carugo, K, Puehringer, D. Deposit date: 2018-12-20 Release date: 2020-06-03 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.8 Å) Cite: A conformation-specific ON-switch for controlling CAR T cells with an orally available drug. Proc.Natl.Acad.Sci.USA, 117, 2020
6S8V	Structure of the high affinity Anticalin P3D11 in complex with the human CD98 heavy chain ectodomain Descriptor: 1,2-ETHANEDIOL, 4F2 cell-surface antigen heavy chain, Neutrophil gelatinase-associated lipocalin Authors: Schiefner, A, Deuschle, F.-C, Skerra, A. Deposit date: 2019-07-10 Release date: 2020-03-04 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Development of a high affinity Anticalin®directed against human CD98hc for theranostic applications. Theranostics, 10, 2020
2RD7	Human Complement Membrane Attack Proteins Share a Common Fold with Bacterial Cytolysins Descriptor: CHLORIDE ION, Complement component C8 alpha chain, Complement component C8 gamma chain Authors: Slade, D.J, Lovelace, L.L, Chruszcz, M, Minor, W, Lebioda, L, Sodetz, J.M. Deposit date: 2007-09-21 Release date: 2008-05-27 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (2.15 Å) Cite: Structure of human C8 protein provides mechanistic insight into membrane pore formation by complement. J. Biol. Chem., 286, 2011
1RLB	RETINOL BINDING PROTEIN COMPLEXED WITH TRANSTHYRETIN Descriptor: RETINOIC ACID, RETINOL BINDING PROTEIN, TRANSTHYRETIN Authors: Monaco, H.L, Rizzi, M, Coda, A. Deposit date: 1995-02-20 Release date: 1996-04-11 Last modified: 2024-06-05 Method: X-RAY DIFFRACTION (3.1 Å) Cite: Structure of a complex of two plasma proteins: transthyretin and retinol-binding protein. Science, 268, 1995
4MVI	Crystal structure of an engineered lipocalin (Anticalin US7) in complex with the Alzheimer amyloid peptide Abeta(1-40) Descriptor: Beta-amyloid protein 40, Neutrophil gelatinase-associated lipocalin Authors: Eichinger, A, Skerra, A. Deposit date: 2013-09-24 Release date: 2015-08-12 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.7 Å) Cite: High-affinity Anticalins with aggregation-blocking activity directed against the Alzheimer beta-amyloid peptide. Biochem.J., 473, 2016
4QAF	Crystal structure of an engineered lipocalin (Anticalin) in complex with VEGF(8-109) Descriptor: 10-{(1R,2R)-2-[(2E)-hex-2-en-1-yl]cyclopropyl}decanoic acid, ACETATE ION, Lipocalin-1, ... Authors: Giese, T, Skerra, A. Deposit date: 2014-05-04 Release date: 2015-05-06 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Crystal structure of an Anticalin with specific blocking activity towards human vascular endothelial growth factor (VEGF) reveals plasticity of the lipocalin fold To be Published
4QAE	Crystal structure of an engineered lipocalin (Anticalin) in complex with human hepcidin Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, CHLORIDE ION, Hepcidin, ... Authors: Giese, T, Skerra, A. Deposit date: 2014-05-04 Release date: 2015-05-06 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Structure of a hepcidin-binding anticalin in complex with its peptide ligand To be Published
8B0H	2C9, C5b9-CD59 cryoEM structure Descriptor: CD59 glycoprotein, Complement C5, Complement component C6, ... Authors: Couves, E.C, Gardner, S, Bubeck, D. Deposit date: 2022-09-07 Release date: 2023-02-22 Last modified: 2023-03-01 Method: ELECTRON MICROSCOPY (3.3 Å) Cite: Structural basis for membrane attack complex inhibition by CD59. Nat Commun, 14, 2023
8B0F	CryoEM structure of C5b8-CD59 Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... Authors: Bubeck, D, Couves, E.C, Gardner, S. Deposit date: 2022-09-07 Release date: 2023-02-22 Last modified: 2023-03-01 Method: ELECTRON MICROSCOPY (3 Å) Cite: Structural basis for membrane attack complex inhibition by CD59. Nat Commun, 14, 2023
8B0G	2C9, C5b9-CD59 structure Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CD59 glycoprotein, Complement C5, ... Authors: Couves, E.C, Gardner, S, Bubeck, D. Deposit date: 2022-09-07 Release date: 2023-02-22 Last modified: 2023-03-01 Method: ELECTRON MICROSCOPY (3.3 Å) Cite: Structural basis for membrane attack complex inhibition by CD59. Nat Commun, 14, 2023

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