6SUA

Structure of the high affinity engineered lipocalin C1B12 in complex with the mouse CD98 heavy chain ectodomain

Summary for 6SUA

Entry DOI	10.2210/pdb6sua/pdb
Descriptor	Neutrophil gelatinase-associated lipocalin, 4F2 cell-surface antigen heavy chain, SULFATE ION, ... (4 entities in total)
Functional Keywords	lipocalin, lcn2, anticalin, lipocalin-based binding protein, cd98hc, 4f2hc, amino acid transport, presentation of cd98 light chain, interaction with integrin beta subunit, single-pass type ii membrane protein, protein binding
Biological source	Homo sapiens (Human) More
Total number of polymer chains	4
Total formula weight	140810.40
Authors	Schiefner, A.,Deuschle, F.-C.,Skerra, A. (deposition date: 2019-09-13, release date: 2020-06-17, Last modification date: 2024-01-24)
Primary citation	Deuschle, F.C.,Schiefner, A.,Brandt, C.,Skerra, A. Design of a surrogate Anticalin protein directed against CD98hc for preclinical studies in mice. Protein Sci., 29:1774-1783, 2020 Cited by PubMed: 32463547 DOI: 10.1002/pro.3894 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.75 Å)

Structure validation