6SUA
Structure of the high affinity engineered lipocalin C1B12 in complex with the mouse CD98 heavy chain ectodomain
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, C | Neutrophil gelatinase-associated lipocalin | polymer | 186 | 21462.3 | 2 | UniProt (P80188) Pfam (PF00061) In PDB | Homo sapiens (Human) | NGAL,25 kDa alpha-2-microglobulin-related subunit of MMP-9,Lipocalin-2,Oncogene 24p3,Siderocalin,p25 |
2 | B, D | 4F2 cell-surface antigen heavy chain | polymer | 434 | 48366.6 | 2 | UniProt (P10852) Pfam (PF00128) In PDB | Mus musculus (Mouse) | 4F2hc,Solute carrier family 3 member 2 |
3 | A, B, C, D | SULFATE ION | non-polymer | 96.1 | 12 | Chemie (SO4) | |||
4 | water | water | 18.0 | 146 | Chemie (HOH) |
Sequence modifications
A, C: 1 - 178 (UniProt: P80188)
B, D: 105 - 526 (UniProt: P10852)
PDB | External Database | Details |
---|---|---|
His 28 | Gln 48 | engineered mutation |
Gly 40 | Ala 60 | engineered mutation |
Asn 41 | Ile 61 | engineered mutation |
Leu 49 | Gln 69 | engineered mutation |
Asp 68 | Ser 88 | engineered mutation |
Ile 72 | Arg 92 | engineered mutation |
Asp 73 | Lys 93 | engineered mutation |
His 77 | Asp 97 | engineered mutation |
Leu 79 | Trp 99 | engineered mutation |
Asn 81 | Arg 101 | engineered mutation |
Ser 87 | Cys 107 | engineered mutation |
Ser 96 | Asn 116 | engineered mutation |
Thr 100 | Tyr 120 | engineered mutation |
Leu 101 | Pro 121 | engineered mutation |
Ser 103 | Leu 123 | engineered mutation |
Arg 106 | Tyr 126 | engineered mutation |
Trp 125 | Lys 145 | engineered mutation |
His 127 | Ser 147 | engineered mutation |
Trp 132 | Tyr 152 | engineered mutation |
Tyr 134 | Lys 154 | engineered mutation |
Ser 179 | - | expression tag |
Ala 180 | - | expression tag |
His 181 | - | expression tag |
His 182 | - | expression tag |
His 183 | - | expression tag |
His 184 | - | expression tag |
His 185 | - | expression tag |
His 186 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Ala 93 | - | expression tag |
Ser 94 | - | expression tag |
Trp 95 | - | expression tag |
Ser 96 | - | expression tag |
His 97 | - | expression tag |
Pro 98 | - | expression tag |
Gln 99 | - | expression tag |
Phe 100 | - | expression tag |
Glu 101 | - | expression tag |
Lys 102 | - | expression tag |
Gly 103 | - | expression tag |
Ala 104 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 139657.6 | |
Non-Polymers* | Number of molecules | 12 |
Total formula weight | 1152.8 | |
All* | Total formula weight | 140810.4 |