6QBA

Crystal Structure of Retinol-Binding Protein 4 (RBP4) in complex with non-retinoid ligand A1120 and engineered binding scaffold

Summary for 6QBA

• Entry DOI: 10.2210/pdb6qba/pdb
• Descriptor: Retinol-binding protein 4, DNA-binding protein 7a, 2-[({4-[2-(trifluoromethyl)phenyl]piperidin-1-yl}carbonyl)amino]benzoic acid, ... (8 entities in total)
• Functional Keywords: lipocalin, rbp4, retinol binding protein, transport protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 29281.70

Authors

Mlynek, G.,Brey, C.U.,Djinovic-Carugo, K.,Puehringer, D. (deposition date: 2018-12-20, release date: 2020-06-03, Last modification date: 2024-01-24)

• Primary citation: Zajc, C.U.,Dobersberger, M.,Schaffner, I.,Mlynek, G.,Puhringer, D.,Salzer, B.,Djinovic-Carugo, K.,Steinberger, P.,De Sousa Linhares, A.,Yang, N.J.,Obinger, C.,Holter, W.,Traxlmayr, M.W.,Lehner, M.; A conformation-specific ON-switch for controlling CAR T cells with an orally available drug.; Proc.Natl.Acad.Sci.USA, 117:14926-14935, 2020; PubMed: 32554495; DOI: 10.1073/pnas.1911154117

Experimental method

X-RAY DIFFRACTION (1.8 Å)