6QBA
Crystal Structure of Retinol-Binding Protein 4 (RBP4) in complex with non-retinoid ligand A1120 and engineered binding scaffold
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Retinol-binding protein 4 | polymer | 185 | 21251.8 | 1 | UniProt (P02753) Pfam (PF00061) | Homo sapiens (Human) | Plasma retinol-binding protein,RBP |
| 2 | B (B) | DNA-binding protein 7a | polymer | 61 | 6930.7 | 1 | UniProt (P61991) Pfam (PF02294) | Sulfolobus solfataricus | 7 kDa DNA-binding protein a,Endoribonuclease P2,p7ss |
| 3 | C (A) | 2-[({4-[2-(trifluoromethyl)phenyl]piperidin-1-yl}carbonyl)amino]benzoic acid | non-polymer | 392.4 | 1 | Chemie (2T1) | |||
| 4 | D, E, F, G, H (A) | IMIDAZOLE | non-polymer | 69.1 | 5 | Chemie (IMD) | |||
| 5 | I (A) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 1 | Chemie (PEG) | |||
| 6 | J, K, L (A) | ZINC ION | non-polymer | 65.4 | 3 | Chemie (ZN) | |||
| 7 | M (B) | ACETATE ION | non-polymer | 59.0 | 1 | Chemie (ACT) | |||
| 8 | N, O (A, B) | water | water | 18.0 | 209 | Chemie (HOH) |
Sequence modifications
A: 1 - 183 (UniProt: P02753)
B: 1 - 61 (UniProt: P61991)
| PDB | External Database | Details |
|---|---|---|
| Gly -1 | - | expression tag |
| Pro 0 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Leu 5 | Phe 6 | conflict |
| Thr 6 | Lys 7 | conflict |
| Gln 8 | Lys 9 | conflict |
| Arg 21 | Lys 22 | conflict |
| Ala 23 | Trp 24 | conflict |
| Tyr 25 | Val 26 | conflict |
| Gln 27 | Lys 28 | conflict |
| Asn 28 | Met 29 | conflict |
| Tyr 30 | Ser 31 | conflict |
| Ser 32 | Thr 33 | conflict |
| Ala 39 | Lys 40 | conflict |
| Tyr 40 | Thr 41 | conflict |
| Asp 41 | Gly 42 | conflict |
| Tyr 42 | Arg 43 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 28182.5 | |
| Non-Polymers* | Number of molecules | 11 |
| Total formula weight | 1099.2 | |
| All* | Total formula weight | 29281.7 |
