6QBA
Crystal Structure of Retinol-Binding Protein 4 (RBP4) in complex with non-retinoid ligand A1120 and engineered binding scaffold
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Retinol-binding protein 4 | polymer | 185 | 21251.8 | 1 | UniProt (P02753) Pfam (PF00061) In PDB | Homo sapiens (Human) | Plasma retinol-binding protein,RBP |
2 | B | DNA-binding protein 7a | polymer | 61 | 6930.7 | 1 | UniProt (P61991) Pfam (PF02294) In PDB | Sulfolobus solfataricus | 7 kDa DNA-binding protein a,Endoribonuclease P2,p7ss |
3 | A | 2-[({4-[2-(trifluoromethyl)phenyl]piperidin-1-yl}carbonyl)amino]benzoic acid | non-polymer | 392.4 | 1 | Chemie (2T1) | |||
4 | A | IMIDAZOLE | non-polymer | 69.1 | 5 | Chemie (IMD) | |||
5 | A | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 1 | Chemie (PEG) | |||
6 | A | ZINC ION | non-polymer | 65.4 | 3 | Chemie (ZN) | |||
7 | B | ACETATE ION | non-polymer | 59.0 | 1 | Chemie (ACT) | |||
8 | water | water | 18.0 | 209 | Chemie (HOH) |
Sequence modifications
A: 1 - 183 (UniProt: P02753)
B: 1 - 61 (UniProt: P61991)
PDB | External Database | Details |
---|---|---|
Gly -1 | - | expression tag |
Pro 0 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Leu 5 | Phe 6 | conflict |
Thr 6 | Lys 7 | conflict |
Gln 8 | Lys 9 | conflict |
Arg 21 | Lys 22 | conflict |
Ala 23 | Trp 24 | conflict |
Tyr 25 | Val 26 | conflict |
Gln 27 | Lys 28 | conflict |
Asn 28 | Met 29 | conflict |
Tyr 30 | Ser 31 | conflict |
Ser 32 | Thr 33 | conflict |
Ala 39 | Lys 40 | conflict |
Tyr 40 | Thr 41 | conflict |
Asp 41 | Gly 42 | conflict |
Tyr 42 | Arg 43 | conflict |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 28182.5 | |
Non-Polymers* | Number of molecules | 11 |
Total formula weight | 1099.2 | |
All* | Total formula weight | 29281.7 |