6QBA
Crystal Structure of Retinol-Binding Protein 4 (RBP4) in complex with non-retinoid ligand A1120 and engineered binding scaffold
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001654 | biological_process | eye development |
| A | 0002639 | biological_process | positive regulation of immunoglobulin production |
| A | 0005501 | molecular_function | retinoid binding |
| A | 0005515 | molecular_function | protein binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005615 | cellular_component | extracellular space |
| A | 0006094 | biological_process | gluconeogenesis |
| A | 0007507 | biological_process | heart development |
| A | 0007601 | biological_process | visual perception |
| A | 0016918 | molecular_function | retinal binding |
| A | 0019841 | molecular_function | retinol binding |
| A | 0030277 | biological_process | maintenance of gastrointestinal epithelium |
| A | 0030324 | biological_process | lung development |
| A | 0032024 | biological_process | positive regulation of insulin secretion |
| A | 0032526 | biological_process | response to retinoic acid |
| A | 0034632 | molecular_function | retinol transmembrane transporter activity |
| A | 0034633 | biological_process | retinol transport |
| A | 0042572 | biological_process | retinol metabolic process |
| A | 0042593 | biological_process | glucose homeostasis |
| A | 0048562 | biological_process | embryonic organ morphogenesis |
| A | 0048706 | biological_process | embryonic skeletal system development |
| A | 0048738 | biological_process | cardiac muscle tissue development |
| A | 0048807 | biological_process | female genitalia morphogenesis |
| A | 0060044 | biological_process | negative regulation of cardiac muscle cell proliferation |
| A | 0060059 | biological_process | embryonic retina morphogenesis in camera-type eye |
| A | 0060065 | biological_process | uterus development |
| A | 0060068 | biological_process | vagina development |
| A | 0060157 | biological_process | urinary bladder development |
| A | 0060347 | biological_process | heart trabecula formation |
| A | 0070062 | cellular_component | extracellular exosome |
| B | 0003677 | molecular_function | DNA binding |
| B | 0004519 | molecular_function | endonuclease activity |
| B | 0004521 | molecular_function | RNA endonuclease activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 14 |
| Details | binding site for residue 2T1 A 201 |
| Chain | Residue |
| A | LEU35 |
| A | PHE135 |
| A | HOH336 |
| A | HOH348 |
| A | HOH390 |
| B | TYR25 |
| A | PHE36 |
| A | LEU37 |
| A | ALA57 |
| A | MET73 |
| A | MET88 |
| A | TYR90 |
| A | HIS104 |
| A | ARG121 |
| site_id | AC2 |
| Number of Residues | 9 |
| Details | binding site for residue IMD A 202 |
| Chain | Residue |
| A | ARG10 |
| A | VAL11 |
| A | GLU13 |
| A | VAL107 |
| A | ARG155 |
| A | GLU158 |
| A | IMD205 |
| A | ZN209 |
| B | GLU10 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue IMD A 203 |
| Chain | Residue |
| A | ASP140 |
| A | GLY143 |
| A | ZN208 |
| B | GLU59 |
| B | HOH204 |
| B | HOH213 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | binding site for residue IMD A 204 |
| Chain | Residue |
| A | TYR25 |
| A | HIS170 |
| A | ASP175 |
| A | IMD206 |
| A | ZN210 |
| A | HOH439 |
| B | GLN56 |
| site_id | AC5 |
| Number of Residues | 7 |
| Details | binding site for residue IMD A 205 |
| Chain | Residue |
| A | LYS12 |
| A | GLU13 |
| A | ASP108 |
| A | ARG155 |
| A | IMD202 |
| A | ZN209 |
| B | GLU10 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | binding site for residue IMD A 206 |
| Chain | Residue |
| A | HIS170 |
| A | GLY172 |
| A | ASP175 |
| A | IMD204 |
| A | ZN210 |
| B | GLN56 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | binding site for residue PEG A 207 |
| Chain | Residue |
| A | ALA28 |
| A | GLN156 |
| A | TYR165 |
| A | HOH327 |
| B | GLU35 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | binding site for residue ZN A 208 |
| Chain | Residue |
| A | ASP140 |
| A | IMD203 |
| B | ARG24 |
| B | GLU59 |
| B | HOH204 |
| B | HOH247 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 209 |
| Chain | Residue |
| A | GLU13 |
| A | IMD202 |
| A | IMD205 |
| B | GLU10 |
| site_id | AD1 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 210 |
| Chain | Residue |
| A | HIS170 |
| A | ASP175 |
| A | IMD204 |
| A | IMD206 |
| site_id | AD2 |
| Number of Residues | 3 |
| Details | binding site for residue ACT B 101 |
| Chain | Residue |
| B | GLU53 |
| B | HOH214 |
| B | HOH227 |
Functional Information from PROSITE/UniProt
| site_id | PS00213 |
| Number of Residues | 14 |
| Details | LIPOCALIN Lipocalin signature. NFDkaRFSGTWYAM |
| Chain | Residue | Details |
| A | ASN14-MET27 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-methyllysine; partial => ECO:0000269|PubMed:8425540 |
| Chain | Residue | Details |
| B | LYS4 | |
| B | THR6 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | MOD_RES: Omega-N-methylarginine => ECO:0000250|UniProtKB:Q00724 |
| Chain | Residue | Details |
| A | ARG121 |
