6QBA
Crystal Structure of Retinol-Binding Protein 4 (RBP4) in complex with non-retinoid ligand A1120 and engineered binding scaffold
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0001654 | biological_process | eye development |
A | 0002639 | biological_process | positive regulation of immunoglobulin production |
A | 0005501 | molecular_function | retinoid binding |
A | 0005515 | molecular_function | protein binding |
A | 0005576 | cellular_component | extracellular region |
A | 0005615 | cellular_component | extracellular space |
A | 0006094 | biological_process | gluconeogenesis |
A | 0007507 | biological_process | heart development |
A | 0007601 | biological_process | visual perception |
A | 0016918 | molecular_function | retinal binding |
A | 0019841 | molecular_function | retinol binding |
A | 0030277 | biological_process | maintenance of gastrointestinal epithelium |
A | 0030324 | biological_process | lung development |
A | 0032024 | biological_process | positive regulation of insulin secretion |
A | 0032526 | biological_process | response to retinoic acid |
A | 0034632 | molecular_function | retinol transmembrane transporter activity |
A | 0034633 | biological_process | retinol transport |
A | 0042572 | biological_process | retinol metabolic process |
A | 0042593 | biological_process | glucose homeostasis |
A | 0048562 | biological_process | embryonic organ morphogenesis |
A | 0048706 | biological_process | embryonic skeletal system development |
A | 0048738 | biological_process | cardiac muscle tissue development |
A | 0048807 | biological_process | female genitalia morphogenesis |
A | 0060044 | biological_process | negative regulation of cardiac muscle cell proliferation |
A | 0060059 | biological_process | embryonic retina morphogenesis in camera-type eye |
A | 0060065 | biological_process | uterus development |
A | 0060068 | biological_process | vagina development |
A | 0060157 | biological_process | urinary bladder development |
A | 0060347 | biological_process | heart trabecula formation |
A | 0070062 | cellular_component | extracellular exosome |
B | 0003677 | molecular_function | DNA binding |
B | 0004519 | molecular_function | endonuclease activity |
B | 0004521 | molecular_function | RNA endonuclease activity |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 14 |
Details | binding site for residue 2T1 A 201 |
Chain | Residue |
A | LEU35 |
A | PHE135 |
A | HOH336 |
A | HOH348 |
A | HOH390 |
B | TYR25 |
A | PHE36 |
A | LEU37 |
A | ALA57 |
A | MET73 |
A | MET88 |
A | TYR90 |
A | HIS104 |
A | ARG121 |
site_id | AC2 |
Number of Residues | 9 |
Details | binding site for residue IMD A 202 |
Chain | Residue |
A | ARG10 |
A | VAL11 |
A | GLU13 |
A | VAL107 |
A | ARG155 |
A | GLU158 |
A | IMD205 |
A | ZN209 |
B | GLU10 |
site_id | AC3 |
Number of Residues | 6 |
Details | binding site for residue IMD A 203 |
Chain | Residue |
A | ASP140 |
A | GLY143 |
A | ZN208 |
B | GLU59 |
B | HOH204 |
B | HOH213 |
site_id | AC4 |
Number of Residues | 7 |
Details | binding site for residue IMD A 204 |
Chain | Residue |
A | TYR25 |
A | HIS170 |
A | ASP175 |
A | IMD206 |
A | ZN210 |
A | HOH439 |
B | GLN56 |
site_id | AC5 |
Number of Residues | 7 |
Details | binding site for residue IMD A 205 |
Chain | Residue |
A | LYS12 |
A | GLU13 |
A | ASP108 |
A | ARG155 |
A | IMD202 |
A | ZN209 |
B | GLU10 |
site_id | AC6 |
Number of Residues | 6 |
Details | binding site for residue IMD A 206 |
Chain | Residue |
A | HIS170 |
A | GLY172 |
A | ASP175 |
A | IMD204 |
A | ZN210 |
B | GLN56 |
site_id | AC7 |
Number of Residues | 5 |
Details | binding site for residue PEG A 207 |
Chain | Residue |
A | ALA28 |
A | GLN156 |
A | TYR165 |
A | HOH327 |
B | GLU35 |
site_id | AC8 |
Number of Residues | 6 |
Details | binding site for residue ZN A 208 |
Chain | Residue |
A | ASP140 |
A | IMD203 |
B | ARG24 |
B | GLU59 |
B | HOH204 |
B | HOH247 |
site_id | AC9 |
Number of Residues | 4 |
Details | binding site for residue ZN A 209 |
Chain | Residue |
A | GLU13 |
A | IMD202 |
A | IMD205 |
B | GLU10 |
site_id | AD1 |
Number of Residues | 4 |
Details | binding site for residue ZN A 210 |
Chain | Residue |
A | HIS170 |
A | ASP175 |
A | IMD204 |
A | IMD206 |
site_id | AD2 |
Number of Residues | 3 |
Details | binding site for residue ACT B 101 |
Chain | Residue |
B | GLU53 |
B | HOH214 |
B | HOH227 |
Functional Information from PROSITE/UniProt
site_id | PS00213 |
Number of Residues | 14 |
Details | LIPOCALIN Lipocalin signature. NFDkaRFSGTWYAM |
Chain | Residue | Details |
A | ASN14-MET27 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 2 |
Details | MOD_RES: N6-methyllysine; partial => ECO:0000269|PubMed:8425540 |
Chain | Residue | Details |
B | LYS4 | |
B | THR6 |
site_id | SWS_FT_FI2 |
Number of Residues | 1 |
Details | MOD_RES: Omega-N-methylarginine => ECO:0000250|UniProtKB:Q00724 |
Chain | Residue | Details |
A | ARG121 |