2CW0
 
 | | Crystal structure of Thermus thermophilus RNA polymerase holoenzyme at 3.3 angstroms resolution | | Descriptor: | DNA-directed RNA polymerase alpha chain, DNA-directed RNA polymerase beta chain, DNA-directed RNA polymerase beta' chain, ... | | Authors: | Tuske, S, Sarafianos, S.G, Wang, X, Hudson, B, Sineva, E, Mukhopadhyay, J, Birktoft, J.J, Leroy, O, Ismail, S, Clark Jr, A.D, Dharia, C, Napoli, A, Laptenko, O, Lee, J, Borukhov, S, Ebright, R.H, Arnold, E. | | Deposit date: | 2005-06-15 | | Release date: | 2005-09-20 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (3.3 Å) | | Cite: | Inhibition of bacterial RNA polymerase by streptolydigin: stabilization of a straight-bridge-helix active-center conformation
Cell(Cambridge,Mass.), 122, 2005
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2BE5
 | | Crystal structure of the T. Thermophilus RNA polymerase holoenzyme in complex with inhibitor tagetitoxin | | Descriptor: | DNA-directed RNA polymerase alpha chain, DNA-directed RNA polymerase beta chain, DNA-directed RNA polymerase beta' chain, ... | | Authors: | Vassylyev, D.G, Svetlov, V, Vassylyeva, M.N, Perederina, A, Igarashi, N, Matsugaki, N, Wakatsuki, S, Artsimovitch, I, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | Deposit date: | 2005-10-22 | | Release date: | 2005-11-08 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Structural basis for transcription inhibition by tagetitoxin
Nat.Struct.Mol.Biol., 12, 2005
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2A6H
 | | Crystal structure of the T. thermophilus RNA polymerase holoenzyme in complex with antibiotic sterptolydigin | | Descriptor: | DNA-directed RNA polymerase alpha chain, DNA-directed RNA polymerase beta chain, DNA-directed RNA polymerase beta' chain, ... | | Authors: | Temiakov, D, Zenkin, N, Vassylyeva, M.N, Perederina, A, Tahirov, T.H, Savkina, M, Zorov, S, Nikiforov, V, Igarashi, N, Matsugaki, N, Wakatsuki, S, Severinov, K, Vassylyev, D.G, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | Deposit date: | 2005-07-02 | | Release date: | 2005-09-20 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Structural basis of transcription inhibition by antibiotic streptolydigin.
Mol.Cell, 19, 2005
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2A68
 | | Crystal structure of the T. thermophilus RNA polymerase holoenzyme in complex with antibiotic rifabutin | | Descriptor: | DNA-directed RNA polymerase alpha chain, DNA-directed RNA polymerase beta chain, DNA-directed RNA polymerase beta' chain, ... | | Authors: | Artsimovitch, I, Vassylyeva, M.N, Svetlov, D, Svetlov, V, Perederina, A, Igarashi, N, Matsugaki, N, Wakatsuki, S, Tahirov, T.H, Vassylyev, D.G, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | Deposit date: | 2005-07-01 | | Release date: | 2005-09-20 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Allosteric modulation of the RNA polymerase catalytic reaction is an essential component of transcription control by rifamycins.
Cell(Cambridge,Mass.), 122, 2005
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2A69
 | | Crystal structure of the T. Thermophilus RNA polymerase holoenzyme in complex with antibiotic rifapentin | | Descriptor: | DNA-directed RNA polymerase alpha chain, DNA-directed RNA polymerase beta chain, DNA-directed RNA polymerase beta' chain, ... | | Authors: | Artsimovitch, I, Vassylyeva, M.N, Svetlov, D, Svetlov, V, Perederina, A, Igarashi, N, Matsugaki, N, Wakatsuki, S, Tahirov, T.H, Vassylyev, D.G, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | Deposit date: | 2005-07-02 | | Release date: | 2005-09-20 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Allosteric modulation of the RNA polymerase catalytic reaction is an essential component of transcription control by rifamycins.
Cell(Cambridge,Mass.), 122, 2005
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2A6E
 | | Crystal structure of the T. Thermophilus RNA polymerase holoenzyme | | Descriptor: | DNA-directed RNA polymerase alpha chain, DNA-directed RNA polymerase beta chain, DNA-directed RNA polymerase beta' chain, ... | | Authors: | Artsimovitch, I, Vassylyeva, M.N, Svetlov, D, Svetlov, V, Perederina, A, Igarashi, N, Matsugaki, N, Wakatsuki, S, Tahirov, T.H, Vassylyev, D.G, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | Deposit date: | 2005-07-02 | | Release date: | 2005-09-20 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Allosteric modulation of the RNA polymerase catalytic reaction is an essential component of transcription control by rifamycins.
Cell(Cambridge,Mass.), 122, 2005
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1ZYR
 | | Structure of Thermus thermophilus RNA polymerase holoenzyme in complex with the antibiotic streptolydigin | | Descriptor: | DNA-directed RNA polymerase alpha chain, DNA-directed RNA polymerase beta chain, DNA-directed RNA polymerase omega chain, ... | | Authors: | Tuske, S, Sarafianos, S.G, Wang, X, Hudson, B, Sineva, E, Mukhopadhyay, J, Birktoft, J.J, Leroy, O, Ismail, S, Clark, A.D, Dharia, C, Napoli, A, Laptenko, O, Lee, J, Borukhov, S, Ebright, R.H, Arnold, E. | | Deposit date: | 2005-06-10 | | Release date: | 2005-09-13 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Inhibition of bacterial RNA polymerase by streptolydigin: stabilization of a straight-bridge-helix active-center conformation.
Cell(Cambridge,Mass.), 122, 2005
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7MKE
 | | Cryo-EM structure of Escherichia coli RNA polymerase bound to lambda PR promoter DNA (class 2) | | Descriptor: | CHAPSO, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... | | Authors: | Saecker, R.M, Darst, S.A, Chen, J. | | Deposit date: | 2021-04-23 | | Release date: | 2021-09-29 | | Last modified: | 2021-10-13 | | Method: | ELECTRON MICROSCOPY (3.7 Å) | | Cite: | Structural origins of Escherichia coli RNA polymerase open promoter complex stability.
Proc.Natl.Acad.Sci.USA, 118, 2021
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7MKJ
 | | Cryo-EM structure of Escherichia coli RNA polymerase bound to T7A1 promoter DNA | | Descriptor: | CHAPSO, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... | | Authors: | Saecker, R.M, Darst, S.A, Chen, J. | | Deposit date: | 2021-04-23 | | Release date: | 2021-09-29 | | Last modified: | 2021-10-13 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | Structural origins of Escherichia coli RNA polymerase open promoter complex stability.
Proc.Natl.Acad.Sci.USA, 118, 2021
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7MKI
 | | Cryo-EM structure of Escherichia coli RNA polymerase bound to lambda PR (-5G to C) promoter DNA | | Descriptor: | CHAPSO, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... | | Authors: | Saecker, R.M, Darst, S.A, Chen, J. | | Deposit date: | 2021-04-23 | | Release date: | 2021-09-29 | | Last modified: | 2021-10-13 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | Structural origins of Escherichia coli RNA polymerase open promoter complex stability.
Proc.Natl.Acad.Sci.USA, 118, 2021
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7MKD
 | | Cryo-EM structure of Escherichia coli RNA polymerase bound to lambda PR promoter DNA (class 1) | | Descriptor: | CHAPSO, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... | | Authors: | Saecker, R.M, Darst, S.A, Chen, J. | | Deposit date: | 2021-04-23 | | Release date: | 2021-09-29 | | Last modified: | 2021-10-13 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Structural origins of Escherichia coli RNA polymerase open promoter complex stability.
Proc.Natl.Acad.Sci.USA, 118, 2021
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7MLB
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7MLI
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7N4E
 | | Escherichia coli sigma 70-dependent paused transcription elongation complex | | Descriptor: | 5'-R(*UP*UP*CP*GP*GP*AP*GP*AP*GP*GP*UP*A)-3', DNA (61-MER), DNA-directed RNA polymerase subunit alpha, ... | | Authors: | Molodtsov, V, Su, M, Ebright, R.H. | | Deposit date: | 2021-06-04 | | Release date: | 2022-06-15 | | Method: | ELECTRON MICROSCOPY (3.8 Å) | | Cite: | Structural and mechanistic basis of sigma-dependent transcriptional pausing.
Proc.Natl.Acad.Sci.USA, 119, 2022
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5VOI
 | | X-ray crystal structure of bacterial RNA polymerase and pyrG promoter complex | | Descriptor: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | | Authors: | Murakami, K.S, Shin, Y, Turnbough Jr, C.L, Molodtsov, V. | | Deposit date: | 2017-05-02 | | Release date: | 2017-05-24 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | X-ray crystal structure of a reiterative transcription complex reveals an atypical RNA extension pathway.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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7MLJ
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7KHC
 | | Escherichia coli RNA polymerase and rrnBP1 promoter closed complex | | Descriptor: | CHAPSO, DNA (18 MER), DNA (63-MER), ... | | Authors: | Shin, Y, Qayyum, M.Z, Murakami, K.S. | | Deposit date: | 2020-10-20 | | Release date: | 2020-10-28 | | Last modified: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (4.14 Å) | | Cite: | Structural basis of ribosomal RNA transcription regulation.
Nat Commun, 12, 2021
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7KHI
 | | Escherichia coli RNA polymerase and rrnBP1 promoter complex with DksA/ppGpp | | Descriptor: | CHAPSO, DNA (28-MER), DNA (36-MER), ... | | Authors: | Shin, Y, Qayyum, M.Z, Murakami, K.S. | | Deposit date: | 2020-10-21 | | Release date: | 2020-10-28 | | Last modified: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (3.62 Å) | | Cite: | Structural basis of ribosomal RNA transcription regulation.
Nat Commun, 12, 2021
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7KHB
 | | Escherichia coli RNA polymerase and rrnBP1 promoter open complex | | Descriptor: | CHAPSO, DNA (60-MER), DNA (64-MER), ... | | Authors: | Shin, Y, Qayyum, M.Z, Murakami, K.S. | | Deposit date: | 2020-10-20 | | Release date: | 2020-10-28 | | Last modified: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (3.53 Å) | | Cite: | Structural basis of ribosomal RNA transcription regulation.
Nat Commun, 12, 2021
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5XJ0
 | | T. thermophilus RNA polymerase holoenzyme bound with gp39 and gp76 | | Descriptor: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | | Authors: | Ooi, W.Y, Murayama, Y, Mekler, V, Minakhin, L, Severinov, K, Yokoyama, S, Sekine, S. | | Deposit date: | 2017-04-28 | | Release date: | 2017-12-20 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (4.004 Å) | | Cite: | A Thermus phage protein inhibits host RNA polymerase by preventing template DNA strand loading during open promoter complex formation
Nucleic Acids Res., 46, 2018
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7L7B
 | | Clostridioides difficile RNAP with fidaxomicin | | Descriptor: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | | Authors: | Boyaci, H, Campbell, E.A, Darst, S.A, Chen, J. | | Deposit date: | 2020-12-28 | | Release date: | 2022-02-02 | | Last modified: | 2022-05-04 | | Method: | ELECTRON MICROSCOPY (3.26 Å) | | Cite: | Basis of narrow-spectrum activity of fidaxomicin on Clostridioides difficile.
Nature, 604, 2022
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5VSW
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5VI8
 | | Structure of a mycobacterium smegmatis transcription initiation complex with an upstream-fork promoter fragment | | Descriptor: | 1,2-ETHANEDIOL, DNA (26-MER), DNA (31-MER), ... | | Authors: | Hubin, E.A, Campbell, E.A, Darst, S.A. | | Deposit date: | 2017-04-14 | | Release date: | 2017-04-26 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (2.76 Å) | | Cite: | Structural insights into the mycobacteria transcription initiation complex from analysis of X-ray crystal structures.
Nat Commun, 8, 2017
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5W1S
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7KHE
 | | Escherichia coli RNA polymerase and rrnBP1 promoter pre-open complex with DksA/ppGpp | | Descriptor: | CHAPSO, DNA (46-MER), DNA (54-MER), ... | | Authors: | Shin, Y, Qayyum, M.Z, Murakami, K.S. | | Deposit date: | 2020-10-21 | | Release date: | 2020-12-09 | | Last modified: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (3.58 Å) | | Cite: | Structural basis of ribosomal RNA transcription regulation.
Nat Commun, 12, 2021
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