2A6E

Crystal structure of the T. Thermophilus RNA polymerase holoenzyme

Summary for 2A6E

Related1IW7 1SMY 2A68 2A69 2a6h
DescriptorDNA-directed RNA polymerase alpha chain, DNA-directed RNA polymerase beta chain, DNA-directed RNA polymerase beta' chain, ... (8 entities in total)
Functional Keywordsrna polymerase holoenzyme, bridge helix, transcription regulation, riken structural genomics/proteomics initiative, rsgi, structural genomics, transferase
Biological sourceThermus thermophilus
Cellular locationCytoplasm  Q5SKW1
Total number of polymer chains12
Total molecular weight853581.22
Authors
Primary citation
Artsimovitch, I.,Vassylyeva, M.N.,Svetlov, D.,Svetlov, V.,Perederina, A.,Igarashi, N.,Matsugaki, N.,Wakatsuki, S.,Tahirov, T.H.,Vassylyev, D.G.
Allosteric modulation of the RNA polymerase catalytic reaction is an essential component of transcription control by rifamycins.
Cell(Cambridge,Mass.), 122:351-363, 2005
PubMed: 16096056 (PDB entries with the same primary citation)
DOI: 10.1016/j.cell.2005.07.014
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.8 Å)
NMR Information
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.261594.6%22.8%0.9%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 2a6e
no rotation
Molmil generated image of 2a6e
rotated about x axis by 90°
Molmil generated image of 2a6e
rotated about y axis by 90°

More Biological unit images

Molmil generated image of 2a6e
no rotation
Molmil generated image of 2a6e
rotated about x axis by 90°
Molmil generated image of 2a6e
rotated about y axis by 90°
(*)In the case of coarse surface representation, the asymmetric unit is shown as red ribbon representation.
Coordinate files for Biological unit (2a6e.pdb1.gz [604.28 KB])
Coordinate files for Biological unit (2a6e.pdb2.gz [598.84 KB])