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2A68

Crystal structure of the T. thermophilus RNA polymerase holoenzyme in complex with antibiotic rifabutin

Summary for 2A68
Entry DOI10.2210/pdb2a68/pdb
Related1IW7 1SMY 2a69 2a6e 2a6h
DescriptorDNA-directed RNA polymerase alpha chain, DNA-directed RNA polymerase beta chain, DNA-directed RNA polymerase beta' chain, ... (9 entities in total)
Functional Keywordsrna polymerase holoenzyme, rifabutin, antibiotic, transcription regulation, riken structural genomics/proteomics initiative, rsgi, structural genomics, transferase
Biological sourceThermus thermophilus
More
Total number of polymer chains12
Total formula weight868886.03
Authors
Primary citationArtsimovitch, I.,Vassylyeva, M.N.,Svetlov, D.,Svetlov, V.,Perederina, A.,Igarashi, N.,Matsugaki, N.,Wakatsuki, S.,Tahirov, T.H.,Vassylyev, D.G.
Allosteric modulation of the RNA polymerase catalytic reaction is an essential component of transcription control by rifamycins.
Cell(Cambridge,Mass.), 122:351-363, 2005
Cited by
PubMed: 16096056
DOI: 10.1016/j.cell.2005.07.014
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.5 Å)
Structure validation

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