2A6H
Crystal structure of the T. thermophilus RNA polymerase holoenzyme in complex with antibiotic sterptolydigin
Summary for 2A6H
Entry DOI | 10.2210/pdb2a6h/pdb |
Related | 1IW7 1SMY 2A68 2A69 2A6E |
Descriptor | DNA-directed RNA polymerase alpha chain, DNA-directed RNA polymerase beta chain, DNA-directed RNA polymerase beta' chain, ... (9 entities in total) |
Functional Keywords | rna polymerase holoenzyme, streptolydigin, antibiotic, transcription regulation, riken structural genomics/proteomics initiative, rsgi, structural genomics, transferase |
Biological source | Thermus thermophilus More |
Cellular location | Cytoplasm : Q5SKW1 |
Total number of polymer chains | 12 |
Total formula weight | 854782.62 |
Authors | Temiakov, D.,Zenkin, N.,Vassylyeva, M.N.,Perederina, A.,Tahirov, T.H.,Savkina, M.,Zorov, S.,Nikiforov, V.,Igarashi, N.,Matsugaki, N.,Wakatsuki, S.,Severinov, K.,Vassylyev, D.G.,RIKEN Structural Genomics/Proteomics Initiative (RSGI) (deposition date: 2005-07-02, release date: 2005-09-20, Last modification date: 2023-08-23) |
Primary citation | Temiakov, D.,Zenkin, N.,Vassylyeva, M.N.,Perederina, A.,Tahirov, T.H.,Kashkina, E.,Savkina, M.,Zorov, S.,Nikiforov, V.,Igarashi, N.,Matsugaki, N.,Wakatsuki, S.,Severinov, K.,Vassylyev, D.G. Structural basis of transcription inhibition by antibiotic streptolydigin. Mol.Cell, 19:655-666, 2005 Cited by PubMed: 16167380DOI: 10.1016/j.molcel.2005.07.020 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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