2A6H
Crystal structure of the T. thermophilus RNA polymerase holoenzyme in complex with antibiotic sterptolydigin
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, G, H (A, B, K, L) | DNA-directed RNA polymerase alpha chain | polymer | 315 | 35056.2 | 4 | UniProt (Q5SHR6) Pfam (PF01193) Pfam (PF01000) Pfam (PF03118) | Thermus thermophilus | RNAP alpha subunit, Transcriptase alpha chain, RNA polymerase alpha subunit |
| 2 | C, I (C, M) | DNA-directed RNA polymerase beta chain | polymer | 1119 | 125436.5 | 2 | UniProt (Q8RQE9) Pfam (PF04563) Pfam (PF04561) Pfam (PF04565) Pfam (PF10385) Pfam (PF00562) Pfam (PF04560) | Thermus thermophilus | RNAP beta subunit, Transcriptase beta chain, RNA polymerase beta subunit |
| 3 | D, J (D, N) | DNA-directed RNA polymerase beta' chain | polymer | 1524 | 170997.4 | 2 | UniProt (Q8RQE8) Pfam (PF04997) Pfam (PF21668) Pfam (PF00623) Pfam (PF04983) Pfam (PF05000) Pfam (PF04998) | Thermus thermophilus | RNAP beta' subunit, Transcriptase beta' chain, RNA polymerase beta' subunit |
| 4 | E, K (E, O) | RNA polymerase omega chain | polymer | 99 | 11521.2 | 2 | UniProt (Q8RQE7) Pfam (PF01192) | Thermus thermophilus | |
| 5 | F, L (F, P) | RNA polymerase sigma factor rpoD | polymer | 423 | 48568.0 | 2 | UniProt (Q5SKW1) Pfam (PF00140) Pfam (PF04542) Pfam (PF04539) Pfam (PF04545) | Thermus thermophilus | |
| 6 | M, Q (D, N) | STREPTOLYDIGIN | non-polymer | 600.7 | 2 | Chemie (STD) PubChem (131884066) PubChem (163008085) PubChem (168300438) PubChem (171378511) PubChem (132350827) PubChem (134944003) PubChem (138979364) PubChem (155901311) PubChem (163008086) PubChem (163008087) PubChem (163008088) PubChem (54684019) PubChem (54686800) PubChem (54687766) PubChem (54690173) PubChem (54706491) PubChem (54707113) PubChem (54708445) PubChem (54708748) PubChem (54715134) PubChem (54719009) PubChem (54727643) PubChem (54727930) PubChem (54728681) PubChem (54730434) PubChem (54733891) PubChem (171318870) PubChem (54688687) PubChem (89839633) PubChem (91995702) PubChem (94865122) PubChem (98093353) PubChem (54728031) PubChem (98502774) PubChem (98502777) PubChem (102514935) | |||
| 7 | N, O, R, S (D, N) | ZINC ION | non-polymer | 65.4 | 4 | Chemie (ZN) | |||
| 8 | P, T (D, N) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) PubChem (888) | |||
| 9 | AA, BA, CA, DA, EA... (K, L, M, N, O...) | water | water | 18.0 | 7398 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 12 |
| Total formula weight | 853271.0 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 1511.6 | |
| All* | Total formula weight | 854782.6 |
