PDB: 337 件ウェブページステータス検索Chemie searchBIRD

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3TG5	Structure of SMYD2 in complex with p53 and SAH 分子名称: Cellular tumor antigen p53, GLYCEROL, N-lysine methyltransferase SMYD2, ... 著者 Zhao, K, Wang, L. 登録日 2011-08-17 公開日 2011-08-31 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structure of human SMYD2 reveals the basis of p53 tumor suppressor methylation J.Biol.Chem., 2011
3VUZ	Crystal structure of histone methyltransferase SET7/9 in complex with AAM-1 分子名称: 5'-{[(3S)-3-amino-3-carboxypropyl](hexyl)amino}-5'-deoxyadenosine, Histone-lysine N-methyltransferase SETD7 著者 Niwa, H, Handa, N, Tomabechi, Y, Honda, K, Toyama, M, Ohsawa, N, Shirouzu, M, Kagechika, H, Hirano, T, Umehara, T, Yokoyama, S. 登録日 2012-07-10 公開日 2013-03-27 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Structures of histone methyltransferase SET7/9 in complexes with adenosylmethionine derivatives Acta Crystallogr.,Sect.D, 69, 2013
3VV0	Crystal structure of histone methyltransferase SET7/9 in complex with DAAM-3 分子名称: 5'-{[(3S)-3-amino-3-carboxypropyl][2-(hexylamino)ethyl]amino}-5'-deoxyadenosine, Histone-lysine N-methyltransferase SETD7 著者 Niwa, H, Handa, N, Tomabechi, Y, Honda, K, Toyama, M, Ohsawa, N, Shirouzu, M, Kagechika, H, Hirano, T, Umehara, T, Yokoyama, S. 登録日 2012-07-10 公開日 2013-03-27 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.001 Å) 主引用文献 Structures of histone methyltransferase SET7/9 in complexes with adenosylmethionine derivatives Acta Crystallogr.,Sect.D, 69, 2013
4AU7	The structure of the Suv4-20h2 ternary complex with histone H4 分子名称: 1,2-ETHANEDIOL, HISTONE H4 PEPTIDE, HISTONE-LYSINE N-METHYLTRANSFERASE SUV420H2, ... 著者 Southall, S.M, Cronin, N.B, Wilson, J.R. 登録日 2012-05-14 公開日 2013-05-22 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.07 Å) 主引用文献 A Novel Route to Product Specificity in the Suv4-20 Family of Histone H4K20 Methyltransferases. Nucleic Acids Res., 42, 2014
4BUP	A novel route to product specificity in the Suv4-20 family of histone H4K20 methyltransferases 分子名称: GLYCEROL, HISTONE-LYSINE N-METHYLTRANSFERASE SUV420H1, S-ADENOSYLMETHIONINE, ... 著者 Southall, S.M, Cronin, N.B, Wilson, J.R. 登録日 2013-06-21 公開日 2013-10-02 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.166 Å) 主引用文献 A Novel Route to Product Specificity in the Suv4-20 Family of Histone H4K20 Methyltransferases. Nucleic Acids Res., 42, 2014
4E47	SET7/9 in complex with inhibitor (R)-(3-(3-cyanophenyl)-1-oxo-1-(pyrrolidin-1-yl)propan-2-yl)-1,2,3,4-tetrahydroisoquinoline-6- sulfonamide and S-adenosylmethionine 分子名称: (R)-(3-(3-cyanophenyl)-1-oxo-1-(pyrrolidin-1-yl)propan-2-yl)-1,2,3,4-tetrahydroisoquinoline-6-sulfonamide, BETA-MERCAPTOETHANOL, Histone-lysine N-methyltransferase SETD7, ... 著者 Walker, J.R, Ouyang, H, Dong, A, Fish, P, Cook, A, Barsyte, D, Vedadi, M, Tatlock, J, Owen, D, Bunnage, M, Bountra, C, Weigelt, J, Edwards, A.M, Arrowsmith, C.H, Brown, P.J, Structural Genomics Consortium (SGC) 登録日 2012-03-12 公開日 2012-03-28 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Setd7 in Complex with Inhibitor and SAM To be Published
4FMU	Crystal structure of Methyltransferase domain of human SET domain-containing protein 2 Compound: Pr-SNF 分子名称: (2S,5S)-2-amino-6-[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]-5-(propylamino)hexanoic acid, Histone-lysine N-methyltransferase SETD2, UNKNOWN ATOM OR ION, ... 著者 Dong, A, Zeng, H, Ibanez, G, Zheng, W, Tempel, W, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Brown, P.J, Min, J, Luo, M, Wu, H, Structural Genomics Consortium (SGC) 登録日 2012-06-18 公開日 2012-09-05 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Sinefungin Derivatives as Inhibitors and Structure Probes of Protein Lysine Methyltransferase SETD2. J.Am.Chem.Soc., 134, 2012
4H12	The crystal structure of methyltransferase domain of human SET domain-containing protein 2 in complex with S-adenosyl-L-homocysteine 分子名称: CHLORIDE ION, Histone-lysine N-methyltransferase SETD2, S-ADENOSYL-L-HOMOCYSTEINE, ... 著者 Amaya, M.F, Dong, A, Zeng, H, Mackenzie, F, Bunnage, M, Weigelt, J, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Wu, H, Structural Genomics Consortium (SGC) 登録日 2012-09-10 公開日 2012-10-03 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.06 Å) 主引用文献 Sinefungin Derivatives as Inhibitors and Structure Probes of Protein Lysine Methyltransferase SETD2. J.Am.Chem.Soc., 134, 2012
4I51	Methyltransferase domain of HUMAN EUCHROMATIC HISTONE METHYLTRANSFERASE 1, mutant Y1211A 分子名称: GLYCEROL, H3K9 NE-ALLYL PEPTIDE, Histone-lysine N-methyltransferase EHMT1, ... 著者 Dong, A, Zeng, H, Walker, J.R, Islam, K, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Lou, M, Min, J, Wu, H, Structural Genomics Consortium (SGC) 登録日 2012-11-28 公開日 2012-12-19 最終更新日 2023-12-06 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Defining efficient enzyme-cofactor pairs for bioorthogonal profiling of protein methylation. Proc.Natl.Acad.Sci.USA, 110, 2013
4IJ8	Crystal structure of the complex of SETD8 with SAM 分子名称: N-lysine methyltransferase SETD8, S-ADENOSYLMETHIONINE, UNKNOWN ATOM OR ION, ... 著者 Yu, W, Tempel, W, Li, Y, El Bakkouri, M, Shapira, M, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Brown, P.J, Structural Genomics Consortium (SGC) 登録日 2012-12-21 公開日 2013-01-16 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Crystal structure of the complex of SETD8 with SAM To be Published
4J7F	SET7/9Y335pAF in complex with TAF10 peptide and AdoHcy 分子名称: Histone-lysine N-methyltransferase SETD7, S-ADENOSYL-L-HOMOCYSTEINE, Transcription initiation factor TFIID subunit 10 著者 Horowitz, S, Del Rizzo, P.A, Trievel, R.C. 登録日 2013-02-13 公開日 2014-03-26 実験手法 X-RAY DIFFRACTION (1.59 Å) 主引用文献 Methyl CH O Hydrogen Bonds Orchestrate AdoMet-Dependent Methylation To be Published
4J7I	SET7/9Y335F in complex with TAF10 peptide and AdoHcy 分子名称: Histone-lysine N-methyltransferase SETD7, S-ADENOSYL-L-HOMOCYSTEINE, Transcription initiation factor TFIID subunit 10 著者 Horowitz, S, Trievel, R.C. 登録日 2013-02-13 公開日 2014-01-08 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.56 Å) 主引用文献 Conservation and functional importance of carbon-oxygen hydrogen bonding in AdoMet-dependent methyltransferases. J.Am.Chem.Soc., 135, 2013
4J83	SET7/9 in complex with TAF10K189A peptide and AdoMet 分子名称: Histone-lysine N-methyltransferase SETD7, S-ADENOSYLMETHIONINE, Transcription initiation factor TFIID subunit 10 著者 Horowitz, S, Nimtz, J.S, Trievel, R.C. 登録日 2013-02-14 公開日 2014-01-08 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Conservation and functional importance of carbon-oxygen hydrogen bonding in AdoMet-dependent methyltransferases. J.Am.Chem.Soc., 135, 2013
4J8O	SET7/9 in complex with TAF10K189A peptide and AdoHcy 分子名称: Histone-lysine N-methyltransferase SETD7, S-ADENOSYL-L-HOMOCYSTEINE, Transcription initiation factor TFIID subunit 10 著者 Horowitz, S, Trievel, R.C. 登録日 2013-02-14 公開日 2014-01-08 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.63 Å) 主引用文献 Conservation and functional importance of carbon-oxygen hydrogen bonding in AdoMet-dependent methyltransferases. J.Am.Chem.Soc., 135, 2013
4JDS	SETD7 in complex with inhibitor PF-5426 and S-adenosyl-methionine 分子名称: Histone-lysine N-methyltransferase SETD7, N-[(2R)-3-(3-cyanophenyl)-1-oxo-1-(pyrrolidin-1-yl)propan-2-yl]-8-fluoro-1,2,3,4-tetrahydroisoquinoline-6-sulfonamide, S-ADENOSYLMETHIONINE, ... 著者 Dong, A, Wu, H, Zeng, H, Park, H, El Bakkouri, M, Barsyte, D, Vedadi, M, Tatlock, J, Owen, D, Bunnage, M, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Brown, P.J, Structural Genomics Consortium (SGC) 登録日 2013-02-25 公開日 2013-03-27 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 SETD7 in complex with inhibitor PF-5426 and S-adenosyl-methionine to be published
4JLG	SETD7 in complex with inhibitor (R)-PFI-2 and S-adenosyl-methionine 分子名称: 8-fluoro-N-{(2R)-1-oxo-1-(pyrrolidin-1-yl)-3-[3-(trifluoromethyl)phenyl]propan-2-yl}-1,2,3,4-tetrahydroisoquinoline-6-sulfonamide, Histone-lysine N-methyltransferase SETD7, S-ADENOSYLMETHIONINE, ... 著者 Dong, A, Wu, H, Zeng, H, El Bakkouri, M, Barsyte, D, Vedadi, M, Tatlock, J, Owen, D, Bunnage, M, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Brown, P.J, Structural Genomics Consortium (SGC) 登録日 2013-03-12 公開日 2013-04-17 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.896 Å) 主引用文献 (R)-PFI-2 is a potent and selective inhibitor of SETD7 methyltransferase activity in cells. Proc.Natl.Acad.Sci.USA, 111, 2014
4LDG	Crystal Structure of CpSET8 from Cryptosporidium, cgd4_370 分子名称: MALONATE ION, Protein with a SET domain within carboxy region 著者 Wernimont, A.K, Tempel, W, Loppnau, P, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Hui, R, El Bakkouri, M, Structural Genomics Consortium (SGC) 登録日 2013-06-24 公開日 2013-07-24 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.31 Å) 主引用文献 Crystal Structure of CpSET8 from Cryptosporidium, cgd4_370 To be Published
4MI0	Human Enhancer of Zeste (Drosophila) Homolog 2(EZH2) 分子名称: Histone-lysine N-methyltransferase EZH2, UNKNOWN ATOM OR ION, ZINC ION 著者 Dong, A, Zeng, H, He, H, Wernimont, A, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Brown, P.J, Wu, H, Structural Genomics Consortium (SGC) 登録日 2013-08-30 公開日 2013-09-25 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structure of the catalytic domain of EZH2 reveals conformational plasticity in cofactor and substrate binding sites and explains oncogenic mutations. Plos One, 8, 2013
4MI5	Crystal structure of the EZH2 SET domain 分子名称: Histone-lysine N-methyltransferase EZH2, SULFATE ION, ZINC ION 著者 Antonysamy, S, Condon, B, Druzina, Z, Bonanno, J, Gheyi, T, Macewan, I, Zhang, A, Ashok, S, Russell, M, Luz, J.G. 登録日 2013-08-30 公開日 2014-01-08 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structural Context of Disease-Associated Mutations and Putative Mechanism of Autoinhibition Revealed by X-Ray Crystallographic Analysis of the EZH2-SET Domain. Plos One, 8, 2013
4NJ5	Crystal structure of SUVH9 分子名称: Probable histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH9, ZINC ION 著者 Du, J, Patel, D.J. 登録日 2013-11-08 公開日 2014-01-22 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 SRA- and SET-domain-containing proteins link RNA polymerase V occupancy to DNA methylation. Nature, 507, 2014
4NVQ	Human G9a in Complex with Inhibitor A-366 分子名称: 5'-methoxy-6'-[3-(pyrrolidin-1-yl)propoxy]spiro[cyclobutane-1,3'-indol]-2'-amine, Histone-lysine N-methyltransferase EHMT2, S-ADENOSYL-L-HOMOCYSTEINE, ... 著者 Sweis, R.F, Pliushchev, M, Brown, P.J, Guo, J, Li, F, Maag, D, Petros, A.M, Soni, N.B, Tse, C, Vedadi, M, Michaelides, M.R, Chiang, G.G, Pappano, W.N. 登録日 2013-12-05 公開日 2014-01-15 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.03 Å) 主引用文献 Discovery and development of potent and selective inhibitors of histone methyltransferase g9a. ACS Med Chem Lett, 5, 2014
4O30	Crystal structure of ATXR5 in complex with histone H3.1 and AdoHcy 分子名称: BETA-MERCAPTOETHANOL, DIMETHYL SULFOXIDE, Histone-lysine N-methyltransferase ATXR6, ... 著者 Bergamin, E, Mongeon, V, Couture, J.F. 登録日 2013-12-17 公開日 2014-03-26 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Selective methylation of histone H3 variant H3.1 regulates heterochromatin replication. Science, 343, 2014
4O6F	Structural Basis of Estrogen Receptor Alpha Methylation Mediated by Histone Methyltransferase SmyD2 分子名称: 3,6,9,12,15,18,21-HEPTAOXATRICOSANE-1,23-DIOL, Estrogen receptor, N-lysine methyltransferase SMYD2, ... 著者 Jiang, Y, Trescott, L, Holcomb, J, Brunzelle, J, Sirinupong, N, Shi, X, Yang, Z. 登録日 2013-12-20 公開日 2014-03-26 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.822 Å) 主引用文献 Structural Insights into Estrogen Receptor alpha Methylation by Histone Methyltransferase SMYD2, a Cellular Event Implicated in Estrogen Signaling Regulation. J.Mol.Biol., 426, 2014
4QEN	crystal structure of KRYPTONITE in complex with mCHH DNA and SAH 分子名称: DNA (5'-D(*AP*CP*TP*GP*AP*TP*GP*AP*GP*TP*AP*CP*CP*AP*T)-3'), DNA (5'-D(*GP*GP*TP*AP*CP*TP*(5CM)P*AP*TP*CP*AP*GP*TP*AP*T)-3'), Histone-lysine N-methyltransferase, ... 著者 Du, J, Li, S, Patel, D.J. 登録日 2014-05-17 公開日 2014-07-30 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.002 Å) 主引用文献 Mechanism of DNA Methylation-Directed Histone Methylation by KRYPTONITE. Mol.Cell, 55, 2014
4QEO	crystal structure of KRYPTONITE in complex with mCHH DNA, H3(1-15) peptide and SAH 分子名称: DNA 5'-ACTGATGAGTACCAT-3', DNA 5'-GGTACT(5CM)ATCAGTAT-3', Histone H3, ... 著者 Du, J, Li, S, Patel, D.J. 登録日 2014-05-17 公開日 2014-07-30 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Mechanism of DNA Methylation-Directed Histone Methylation by KRYPTONITE. Mol.Cell, 55, 2014

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