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4JDS

SETD7 in complex with inhibitor PF-5426 and S-adenosyl-methionine

Summary for 4JDS
Entry DOI10.2210/pdb4jds/pdb
DescriptorHistone-lysine N-methyltransferase SETD7, S-ADENOSYLMETHIONINE, N-[(2R)-3-(3-cyanophenyl)-1-oxo-1-(pyrrolidin-1-yl)propan-2-yl]-8-fluoro-1,2,3,4-tetrahydroisoquinoline-6-sulfonamide, ... (5 entities in total)
Functional Keywordssetd7, sam, pf-5426, structural genomics consortium, sgc, methyltransferase, set domain, histone modification, transcription regulation, histone lysine methyltransferase, inhibitor, s-adenosyl-l-methionine, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceHomo sapiens (human)
Cellular locationNucleus: Q8WTS6
Total number of polymer chains4
Total formula weight122155.68
Authors
Primary citationDong, A.,Wu, H.,Zeng, H.,El Bakkouri, M.,Barsyte, D.,Vedadi, M.,Tatlock, J.,Owen, D.,Bunnage, M.,Bountra, C.,Arrowsmith, C.H.,Edwards, A.M.,Brown, P.J.
SETD7 in complex with inhibitor PF-5426 and S-adenosyl-methionine
to be published,
Experimental method
X-RAY DIFFRACTION (1.7 Å)
Structure validation

217705

PDB entries from 2024-03-27

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