4JDS
SETD7 in complex with inhibitor PF-5426 and S-adenosyl-methionine
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D | Histone-lysine N-methyltransferase SETD7 | polymer | 264 | 29684.0 | 4 | UniProt (Q8WTS6) Pfam (PF22648) Pfam (PF00856) In PDB | Homo sapiens (human) | Histone H3-K4 methyltransferase SETD7, H3-K4-HMTase SETD7, Lysine N-methyltransferase 7, SET domain-containing protein 7, SET7/9 |
2 | A, C, D, B | S-ADENOSYLMETHIONINE | non-polymer | 398.4 | 4 | Chemie (SAM) | |||
3 | A, C, D, B | N-[(2R)-3-(3-cyanophenyl)-1-oxo-1-(pyrrolidin-1-yl)propan-2-yl]-8-fluoro-1,2,3,4-tetrahydroisoquinoline-6-sulfonamide | non-polymer | 456.5 | 4 | Chemie (1L4) | |||
4 | B, A, C, D | UNKNOWN ATOM OR ION | non-polymer | 37 | Chemie (UNX) | ||||
5 | water | water | 18.0 | 953 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 109 - 366 (UniProt: Q8WTS6)
PDB | External Database | Details |
---|---|---|
His 367 | - | expression tag |
His 368 | - | expression tag |
His 369 | - | expression tag |
His 370 | - | expression tag |
His 371 | - | expression tag |
His 372 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 118735.8 | |
Non-Polymers* | Number of molecules | 45 |
Total formula weight | 3419.9 | |
All* | Total formula weight | 122155.7 |