4JDS
SETD7 in complex with inhibitor PF-5426 and S-adenosyl-methionine
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Histone-lysine N-methyltransferase SETD7 | polymer | 264 | 29684.0 | 4 | UniProt (Q8WTS6) Pfam (PF22648) Pfam (PF00856) | Homo sapiens (human) | Histone H3-K4 methyltransferase SETD7, H3-K4-HMTase SETD7, Lysine N-methyltransferase 7, SET domain-containing protein 7, SET7/9 |
| 2 | E, EA, PA, U (A, C, D, B) | S-ADENOSYLMETHIONINE | non-polymer | 398.4 | 4 | Chemie (SAM) PubChem (5136) PubChem (34755) PubChem (58633578) PubChem (60038769) PubChem (58766358) PubChem (73897310) PubChem (9865603) PubChem (87224684) PubChem (12312798) PubChem (131697735) PubChem (145712080) PubChem (132988922) PubChem (134692588) PubChem (135030730) PubChem (140459785) PubChem (163046094) | |||
| 3 | F, FA, QA, V (A, C, D, B) | N-[(2R)-3-(3-cyanophenyl)-1-oxo-1-(pyrrolidin-1-yl)propan-2-yl]-8-fluoro-1,2,3,4-tetrahydroisoquinoline-6-sulfonamide | non-polymer | 456.5 | 4 | Chemie (1L4) PubChem (71296073) | |||
| 4 | AA, BA, CA, DA, G... (B, A, C, D) | UNKNOWN ATOM OR ION | non-polymer | 37 | Chemie (UNX) | ||||
| 5 | AB, XA, YA, ZA (D, A, B, C) | water | water | 18.0 | 953 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 109 - 366 (UniProt: Q8WTS6)
| PDB | External Database | Details |
|---|---|---|
| His 367 | - | expression tag |
| His 368 | - | expression tag |
| His 369 | - | expression tag |
| His 370 | - | expression tag |
| His 371 | - | expression tag |
| His 372 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 118735.8 | |
| Non-Polymers* | Number of molecules | 45 |
| Total formula weight | 3419.9 | |
| All* | Total formula weight | 122155.7 |
