PDB: 13258 resultsInfo pagesStatus searchChemie searchBIRD

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6FXV	Crystal structure of ERK2 in complex with an adenosine derivative Descriptor: DIMETHYL SULFOXIDE, Mitogen-activated protein kinase 1, SULFATE ION, ... Authors: Gelin, M, Labesse, G. Deposit date: 2018-03-09 Release date: 2019-03-20 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (1.53 Å) Cite: None To be published
8VCI	SARS-CoV-2 Frameshift Stimulatory Element with Upstream Multibranch Loop Descriptor: Frameshift Stimulatory Element with Upstream Multi-branch Loop Authors: Peterson, J.M, Becker, S.T, O'Leary, C.A, Juneja, P, Yang, Y, Moss, W.N. Deposit date: 2023-12-14 Release date: 2024-01-17 Last modified: 2024-05-29 Method: ELECTRON MICROSCOPY (6.1 Å) Cite: Structure of the SARS-CoV-2 Frameshift Stimulatory Element with an Upstream Multibranch Loop. Biochemistry, 63, 2024
6G91	Fragment-based discovery of a highly potent, orally bioavailable inhibitor which modulates the phosphorylation and catalytic activity of ERK1/2 Descriptor: 5-chloranyl-~{N}-(oxan-4-yl)pyrimidin-2-amine, Mitogen-activated protein kinase 1, SULFATE ION Authors: O'Reilly, M. Deposit date: 2018-04-10 Release date: 2018-05-30 Last modified: 2018-06-27 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Fragment-Based Discovery of a Potent, Orally Bioavailable Inhibitor That Modulates the Phosphorylation and Catalytic Activity of ERK1/2. J. Med. Chem., 61, 2018
6G9K	Fragment-based discovery of a highly potent, orally bioavailable inhibitor which modulates the phosphorylation and catalytic activity of ERK1/2 Descriptor: 2-[5-[5-chloranyl-2-(oxan-4-ylamino)pyrimidin-4-yl]-3-oxidanylidene-1~{H}-isoindol-2-yl]-~{N}-[(1~{S})-2-oxidanyl-1-phenyl-ethyl]ethanamide, Mitogen-activated protein kinase 1, SULFATE ION Authors: O'Reilly, M. Deposit date: 2018-04-11 Release date: 2018-05-30 Last modified: 2018-06-27 Method: X-RAY DIFFRACTION (1.94 Å) Cite: Fragment-Based Discovery of a Potent, Orally Bioavailable Inhibitor That Modulates the Phosphorylation and Catalytic Activity of ERK1/2. J. Med. Chem., 61, 2018
8IYJ	Cryo-EM structure of the 48-nm repeat doublet microtubule from mouse sperm Descriptor: Cilia and flagella-associated protein 77, Cilia- and flagella-associated protein 107, Cilia- and flagella-associated protein 141, ... Authors: Zhou, L.N, Gui, M, Wu, J.P. Deposit date: 2023-04-05 Release date: 2023-07-05 Last modified: 2024-07-03 Method: ELECTRON MICROSCOPY (3.5 Å) Cite: Structures of sperm flagellar doublet microtubules expand the genetic spectrum of male infertility. Cell, 186, 2023
6G93	Fragment-based discovery of a highly potent, orally bioavailable inhibitor which modulates the phosphorylation and catalytic activity of ERK1/2 Descriptor: 6-[5-chloranyl-2-(oxan-4-ylamino)pyrimidin-4-yl]-2,3-dihydroisoindol-1-one, Mitogen-activated protein kinase 1, SULFATE ION Authors: O'Reilly, M. Deposit date: 2018-04-10 Release date: 2018-05-30 Last modified: 2018-06-27 Method: X-RAY DIFFRACTION (1.67 Å) Cite: Fragment-Based Discovery of a Potent, Orally Bioavailable Inhibitor That Modulates the Phosphorylation and Catalytic Activity of ERK1/2. J. Med. Chem., 61, 2018
6G9J	Fragment-based discovery of a highly potent, orally bioavailable inhibitor which modulates the phosphorylation and catalytic activity of ERK1/2 Descriptor: 2-[5-[5-chloranyl-2-(oxan-4-ylamino)pyrimidin-4-yl]-3-oxidanylidene-1~{H}-isoindol-2-yl]-~{N}-[(1~{R})-1-phenylethyl]ethanamide, Mitogen-activated protein kinase 1, SULFATE ION Authors: O'Reilly, M. Deposit date: 2018-04-10 Release date: 2018-05-30 Last modified: 2018-06-27 Method: X-RAY DIFFRACTION (1.98 Å) Cite: Fragment-Based Discovery of a Potent, Orally Bioavailable Inhibitor That Modulates the Phosphorylation and Catalytic Activity of ERK1/2. J. Med. Chem., 61, 2018
6FR1	Crystal structure of ERK2 in complex with an adenosine derivative Descriptor: DIMETHYL SULFOXIDE, Mitogen-activated protein kinase 1, SULFATE ION, ... Authors: Gelin, M, Labesse, G. Deposit date: 2018-02-15 Release date: 2019-03-13 Method: X-RAY DIFFRACTION (1.561 Å) Cite: None To be published
8QBM	Retron-Eco1 filament with ADP-ribosylated Effector (full map with 2 segments) Descriptor: MAGNESIUM ION, Retron Ec86 putative ribosyltransferase/DNA-binding protein, Retron Ec86 reverse transcriptase, ... Authors: Carabias del Rey, A, Montoya, G. Deposit date: 2023-08-24 Release date: 2024-06-05 Last modified: 2024-06-19 Method: ELECTRON MICROSCOPY (3.09 Å) Cite: Retron-Eco1 assembles NAD + -hydrolyzing filaments that provide immunity against bacteriophages. Mol.Cell, 84, 2024
8QBK	Retron-Eco1 filament with ADP-ribosylated Effector (local map with 1 segment) Descriptor: MAGNESIUM ION, Retron Ec86 putative ribosyltransferase/DNA-binding protein, Retron Ec86 reverse transcriptase, ... Authors: Carabias del Rey, A, Montoya, G. Deposit date: 2023-08-24 Release date: 2024-06-05 Last modified: 2024-06-19 Method: ELECTRON MICROSCOPY (2.99 Å) Cite: Retron-Eco1 assembles NAD + -hydrolyzing filaments that provide immunity against bacteriophages. Mol.Cell, 84, 2024
8QBL	Retron-Eco1 filament with inactive effector (E106A, 2 segments) Descriptor: MAGNESIUM ION, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, Retron Ec86 putative ribosyltransferase/DNA-binding protein, ... Authors: Carabias del Rey, A, Montoya, G. Deposit date: 2023-08-24 Release date: 2024-06-05 Last modified: 2024-06-19 Method: ELECTRON MICROSCOPY (2.66 Å) Cite: Retron-Eco1 assembles NAD + -hydrolyzing filaments that provide immunity against bacteriophages. Mol.Cell, 84, 2024
6FN5	Crystal structure of ERK2 in complex with an adenosine derivative Descriptor: DIMETHYL SULFOXIDE, Mitogen-activated protein kinase 1, SULFATE ION, ... Authors: Gelin, M, Labesse, G. Deposit date: 2018-02-02 Release date: 2019-03-13 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (1.932 Å) Cite: None To be published
6GJD	Erk2 signalling protein Descriptor: DIMETHYL SULFOXIDE, GLYCEROL, Mitogen-activated protein kinase 1, ... Authors: O'Reilly, M. Deposit date: 2018-05-16 Release date: 2019-01-02 Method: X-RAY DIFFRACTION (1.58 Å) Cite: Quantitation of ERK1/2 inhibitor cellular target occupancies with a reversible slow off-rate probe. Chem Sci, 9, 2018
6G54	Crystal structure of ERK2 covalently bound to SM1-71 Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, Mitogen-activated protein kinase 1, ... Authors: Chaikuad, A, Suman, R, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Gray, N.S, Knapp, S, Structural Genomics Consortium (SGC) Deposit date: 2018-03-29 Release date: 2019-02-27 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2.05 Å) Cite: Leveraging Compound Promiscuity to Identify Targetable Cysteines within the Kinome. Cell Chem Biol, 26, 2019
3WYG	Crystal structure of Xpo1p-PKI-Gsp1p-GTP complex Descriptor: Exportin-1, GUANOSINE-5'-TRIPHOSPHATE, Gsp1p, ... Authors: Koyama, M, Shirai, N, Matsuura, Y. Deposit date: 2014-08-26 Release date: 2014-11-12 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.15 Å) Cite: Structural insights into how yrb2p accelerates the assembly of the xpo1p nuclear export complex Cell Rep, 9, 2014
5LAR	Crystal structure of p38 alpha MAPK14 in complex with VPC00628 Descriptor: 5-azanyl-~{N}-[[4-[[(2~{S})-1-azanyl-4-cyclohexyl-1-oxidanylidene-butan-2-yl]carbamoyl]phenyl]methyl]-1-phenyl-pyrazole-4-carboxamide, Mitogen-activated protein kinase 14 Authors: Chaikuad, A, Petersen, L.K, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Knapp, S, Structural Genomics Consortium (SGC) Deposit date: 2016-06-14 Release date: 2016-07-06 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Novel p38alpha MAP kinase inhibitors identified from yoctoReactor DNA-encoded small molecule library Medchemcomm, 7, 2016
6G9N	Fragment-based discovery of a highly potent, orally bioavailable inhibitor which modulates the phosphorylation and catalytic activity of ERK1/2 Descriptor: (2~{R})-2-[5-[5-chloranyl-2-(oxan-4-ylamino)pyrimidin-4-yl]-3-oxidanylidene-1~{H}-isoindol-2-yl]-~{N}-[(1~{S})-1-(3-methylphenyl)-2-oxidanyl-ethyl]propanamide, Mitogen-activated protein kinase 1, SULFATE ION Authors: O'Reilly, M. Deposit date: 2018-04-11 Release date: 2018-05-30 Last modified: 2018-06-27 Method: X-RAY DIFFRACTION (1.76 Å) Cite: Fragment-Based Discovery of a Potent, Orally Bioavailable Inhibitor That Modulates the Phosphorylation and Catalytic Activity of ERK1/2. J. Med. Chem., 61, 2018
8AS4	Crystal structure of human beta-arrestin-1 Descriptor: Beta-arrestin-1 Authors: Jakob, R.P, Panwalkar, V, Grzesiek, S. Deposit date: 2022-08-18 Release date: 2023-06-07 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2.3 Å) Cite: A key GPCR phosphorylation motif discovered in arrestin2⋅CCR5 phosphopeptide complexes. Mol.Cell, 83, 2023
2AHM	Crystal structure of SARS-CoV super complex of non-structural proteins: the hexadecamer Descriptor: GLYCEROL, Replicase polyprotein 1ab, heavy chain, ... Authors: Zhai, Y.J, Sun, F, Bartlam, M, Rao, Z. Deposit date: 2005-07-28 Release date: 2005-11-15 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Insights into SARS-CoV transcription and replication from the structure of the nsp7-nsp8 hexadecamer NAT.STRUCT.MOL.BIOL., 12, 2005
8ARI	Cryo-EM structure of human CtBP1/RAI2(303-362) delta(331-341) filament Descriptor: C-terminal-binding protein 1, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, Retinoic acid-induced protein 2 Authors: Mullapudi, E, Goradia, N, Wilmanns, M. Deposit date: 2022-08-16 Release date: 2023-08-23 Method: ELECTRON MICROSCOPY (3 Å) Cite: Cryo-EM structure of human CtBP1/RAI2(303-362) delta(331-341) filament To Be Published
2IC3	Crystal Structure of K103N/Y181C Mutant HIV-1 Reverse Transcriptase (RT) in Complex with Nonnucleoside Inhibitor HBY 097 Descriptor: (S)-4-ISOPROPOXYCARBONYL-6-METHOXY-3-METHYLTHIOMETHYL-3,4-DIHYDROQUINOXALIN-2(1H)-THIONE, MANGANESE (II) ION, Reverse transcriptase/ribonuclease H (p51 RT), ... Authors: Das, K, Arnold, E. Deposit date: 2006-09-12 Release date: 2006-12-19 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (3 Å) Cite: Crystal Structures of Clinically Relevant Lys103Asn/Tyr181Cys Double Mutant HIV-1 Reverse Transcriptase in Complexes with ATP and Non-nucleoside Inhibitor HBY 097. J.Mol.Biol., 365, 2007
3W55	The structure of ERK2 in complex with FR148083 Descriptor: (3S,5Z,8S,9S,11E)-8,9,16-trihydroxy-14-methoxy-3-methyl-3,4,9,10-tetrahydro-1H-2-benzoxacyclotetradecine-1,7(8H)-dione, Mitogen-activated protein kinase 1 Authors: Ohori, M, Kinoshita, T. Deposit date: 2013-01-21 Release date: 2013-02-06 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (3 Å) Cite: Role of a cysteine residue in the active site of ERK and the MAPKK family Biochem.Biophys.Res.Commun., 353, 2007
3DLK	Crystal Structure of an engineered form of the HIV-1 Reverse Transcriptase, RT69A Descriptor: Reverse transcriptase/ribonuclease H, SULFATE ION, p51 RT Authors: Ho, W.C, Bauman, J.D, Himmel, D.M, Das, K, Arnold, E. Deposit date: 2008-06-27 Release date: 2008-10-07 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (1.85 Å) Cite: Crystal engineering of HIV-1 reverse transcriptase for structure-based drug design. Nucleic Acids Res., 36, 2008
1F66	2.6 A CRYSTAL STRUCTURE OF A NUCLEOSOME CORE PARTICLE CONTAINING THE VARIANT HISTONE H2A.Z Descriptor: HISTONE H2A.Z, HISTONE H2B, HISTONE H3, ... Authors: Suto, R.K, Clarkson, M.J, Tremethick, D.J, Luger, K. Deposit date: 2000-06-20 Release date: 2000-11-27 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Crystal structure of a nucleosome core particle containing the variant histone H2A.Z. Nat.Struct.Biol., 7, 2000
3ZU7	Crystal structure of a designed selected Ankyrin Repeat protein in complex with the MAP kinase ERK2 Descriptor: DESIGNED ANKYRIN REPEAT PROTEIN, MITOGEN-ACTIVATED PROTEIN KINASE 1 Authors: Kummer, L, Mittl, P.R, Pluckthun, A. Deposit date: 2011-07-16 Release date: 2012-06-27 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (1.97 Å) Cite: Structural and Functional Analysis of Phosphorylation-Specific Binders of the Kinase Erk from Designed Ankyrin Repeat Protein Libraries. Proc.Natl.Acad.Sci.USA, 109, 2012

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