2AHM

Crystal structure of SARS-CoV super complex of non-structural proteins: the hexadecamer

Summary for 2AHM

DescriptorReplicase polyprotein 1ab, light chain, Replicase polyprotein 1ab, heavy chain, GLYCEROL, ... (5 entities in total)
Functional Keywordssars-cov, coronavirus, non-structural protein, nsp7, nsp8, super-complex, hexadecamer, viral protein, replication
Biological sourceSARS coronavirus
Cellular locationNon-structural protein 3: Host membrane; Multi-pass membrane protein (Potential). Non-structural protein 4: Host membrane; Multi-pass membrane protein (Potential). Non-structural protein 6: Host membrane; Multi-pass membrane protein (Potential). Non-structural protein 7: Host cytoplasm, host perinuclear region (By similarity). Non-structural protein 8: Host cytoplasm, host perinuclear region (By similarity). Non-structural protein 9: Host cytoplasm, host perinuclear region (By similarity). Non-structural protein 10: Host cytoplasm, host perinuclear region (By similarity). Helicase: Host endoplasmic reticulum-Golgi intermediate compartment (Potential). Uridylate-specific endoribonuclease: Host cytoplasm, host perinuclear region (By similarity) P59641 P59641
Total number of polymer chains8
Total molecular weight128507.4
Authors
Zhai, Y.J.,Sun, F.,Bartlam, M.,Rao, Z. (deposition date: 2005-07-28, release date: 2005-11-15, Last modification date: 2011-07-13)
Primary citation
Zhai, Y.J.,Sun, F.,Li, X.,Pang, H.,Xu, X.,Bartlam, M.,Rao, Z.
Insights into SARS-CoV transcription and replication from the structure of the nsp7-nsp8 hexadecamer
NAT.STRUCT.MOL.BIOL., 12:980-986, 2005
PubMed: 16228002 (PDB entries with the same primary citation)
DOI: 10.1038/nsmb999
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.4 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.24418 0.7% 5.2% 5.0%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload
171313
PDB entries from 2020-11-18