Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

2IC3

Crystal Structure of K103N/Y181C Mutant HIV-1 Reverse Transcriptase (RT) in Complex with Nonnucleoside Inhibitor HBY 097

Summary for 2IC3
Entry DOI10.2210/pdb2ic3/pdb
Related1DLO 1SV5 1UWB 1bqM 2iaj
DescriptorReverse transcriptase/ribonuclease H (p66 RT), Reverse transcriptase/ribonuclease H (p51 RT), MANGANESE (II) ION, ... (5 entities in total)
Functional Keywordsrt, nnrti, nonnucleoside inhibitor, drug resistance, hiv, aids, drug design, transferase
Biological sourceHuman immunodeficiency virus type 1 BH10
More
Cellular locationGag-Pol polyprotein: Host cell membrane; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P03366 P03366
Total number of polymer chains2
Total formula weight116791.82
Authors
Das, K.,Arnold, E. (deposition date: 2006-09-12, release date: 2006-12-19, Last modification date: 2023-08-30)
Primary citationDas, K.,Sarafianos, S.G.,Clark, A.D.,Boyer, P.L.,Hughes, S.H.,Arnold, E.
Crystal Structures of Clinically Relevant Lys103Asn/Tyr181Cys Double Mutant HIV-1 Reverse Transcriptase in Complexes with ATP and Non-nucleoside Inhibitor HBY 097.
J.Mol.Biol., 365:77-89, 2007
Cited by
PubMed: 17056061
DOI: 10.1016/j.jmb.2006.08.097
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (3 Å)
Structure validation

217705

PDB entries from 2024-03-27

PDB statisticsPDBj update infoContact PDBjnumon