3DLK
Crystal Structure of an engineered form of the HIV-1 Reverse Transcriptase, RT69A
Summary for 3DLK
Entry DOI | 10.2210/pdb3dlk/pdb |
Descriptor | Reverse transcriptase/ribonuclease H, p51 RT, SULFATE ION, ... (4 entities in total) |
Functional Keywords | aids, hiv, reverse transcriptase, rt, crystal engineering, rna-binding, rna-directed dna polymerase, transferase, viral nucleoprotein |
Biological source | Human immunodeficiency virus type 1 BH10 (HIV-1) More |
Cellular location | Gag-Pol polyprotein: Host cell membrane; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P03366 P03366 |
Total number of polymer chains | 2 |
Total formula weight | 113574.14 |
Authors | Ho, W.C.,Bauman, J.D.,Himmel, D.M.,Das, K.,Arnold, E. (deposition date: 2008-06-27, release date: 2008-10-07, Last modification date: 2023-08-30) |
Primary citation | Bauman, J.D.,Das, K.,Ho, W.C.,Baweja, M.,Himmel, D.M.,Clark, A.D.,Oren, D.A.,Boyer, P.L.,Hughes, S.H.,Shatkin, A.J.,Arnold, E. Crystal engineering of HIV-1 reverse transcriptase for structure-based drug design. Nucleic Acids Res., 36:5083-5092, 2008 Cited by PubMed: 18676450DOI: 10.1093/nar/gkn464 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.85 Å) |
Structure validation
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