3DLK

Crystal Structure of an engineered form of the HIV-1 Reverse Transcriptase, RT69A

Summary for 3DLK

• Entry DOI: 10.2210/pdb3dlk/pdb
• Descriptor: Reverse transcriptase/ribonuclease H, p51 RT, SULFATE ION, ... (4 entities in total)
• Functional Keywords: aids, hiv, reverse transcriptase, rt, crystal engineering, rna-binding, rna-directed dna polymerase, transferase, viral nucleoprotein
• Biological source: Human immunodeficiency virus type 1 BH10 (HIV-1); More
• Cellular location: Gag-Pol polyprotein: Host cell membrane; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P03366 P03366
• Total number of polymer chains: 2
• Total formula weight: 113574.14

Authors

Ho, W.C.,Bauman, J.D.,Himmel, D.M.,Das, K.,Arnold, E. (deposition date: 2008-06-27, release date: 2008-10-07, Last modification date: 2023-08-30)

• Primary citation: Bauman, J.D.,Das, K.,Ho, W.C.,Baweja, M.,Himmel, D.M.,Clark, A.D.,Oren, D.A.,Boyer, P.L.,Hughes, S.H.,Shatkin, A.J.,Arnold, E.; Crystal engineering of HIV-1 reverse transcriptase for structure-based drug design.; Nucleic Acids Res., 36:5083-5092, 2008; PubMed: 18676450; DOI: 10.1093/nar/gkn464

Experimental method

X-RAY DIFFRACTION (1.85 Å)