1QJ3
| Crystal structure of 7,8-diaminopelargonic acid synthase in complex with 7-keto-8-aminopelargonic acid | Descriptor: | 7,8-DIAMINOPELARGONIC ACID SYNTHASE, 7-KETO-8-AMINOPELARGONIC ACID, PYRIDOXAL-5'-PHOSPHATE, ... | Authors: | Kaeck, H, Sandmark, J, Gibson, K.J, Lindqvist, Y, Schneider, G. | Deposit date: | 1999-06-21 | Release date: | 2000-06-22 | Last modified: | 2019-05-08 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Crystal Structure of Diaminopelargonic Acid Synthase; Evolutionary Relationships between Pyridoxal-5'-Phosphate Dependent Enzymes J.Mol.Biol., 291, 1999
|
|
3B28
| Hsp90 alpha N-terminal domain in complex with an inhibitor CH5015765 | Descriptor: | 4-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-6-(methylsulfanyl)-1,3,5-triazin-2-amine, GLYCEROL, Heat shock protein HSP 90-alpha, ... | Authors: | Fukami, T.A, Ono, N. | Deposit date: | 2011-07-21 | Release date: | 2011-09-14 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.35 Å) | Cite: | Lead generation of heat shock protein 90 inhibitors by a combination of fragment-based approach, virtual screening, and structure-based drug design Bioorg.Med.Chem.Lett., 21, 2011
|
|
3GIA
| Crystal Structure of ApcT Transporter | Descriptor: | BICINE, DECANE, Uncharacterized protein MJ0609 | Authors: | Shaffer, P.L, Goehring, A.S, Shankaranarayanan, A, Gouaux, E, New York Consortium on Membrane Protein Structure (NYCOMPS) | Deposit date: | 2009-03-05 | Release date: | 2009-08-18 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.32 Å) | Cite: | Structure and mechanism of a na+-independent amino Acid transporter. Science, 325, 2009
|
|
3GI9
| Crystal Structure of ApcT Transporter Bound to 7F11 Monoclonal Fab Fragment | Descriptor: | 7F11 Anti-ApcT Monoclonal Fab Heavy Chain, 7F11 Anti-ApcT Monoclonal Fab Light Chain, Uncharacterized protein MJ0609 | Authors: | Shaffer, P.L, Goehring, A.S, Shankaranarayanan, A, Gouaux, E, New York Consortium on Membrane Protein Structure (NYCOMPS) | Deposit date: | 2009-03-05 | Release date: | 2009-08-18 | Last modified: | 2017-06-07 | Method: | X-RAY DIFFRACTION (2.48 Å) | Cite: | Structure and mechanism of a na+-independent amino Acid transporter. Science, 325, 2009
|
|
3GI8
| Crystal Structure of ApcT K158A Transporter Bound to 7F11 Monoclonal Fab Fragment | Descriptor: | 7F11 Anti-ApcT Monoclonal Fab Heavy Chain, 7F11 Anti-ApcT Monoclonal Fab Light Chain, Uncharacterized protein MJ0609 | Authors: | Shaffer, P.L, Goehring, A.S, Shankaranarayanan, A, Gouaux, E, New York Consortium on Membrane Protein Structure (NYCOMPS) | Deposit date: | 2009-03-05 | Release date: | 2009-08-18 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.59 Å) | Cite: | Structure and mechanism of a na+-independent amino Acid transporter. Science, 325, 2009
|
|
1K8P
| |
3NXP
| Crystal structure of human prethrombin-1 | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, ... | Authors: | Chen, Z, Bush-Pelc, L.A, Di Cera, E. | Deposit date: | 2010-07-14 | Release date: | 2010-11-10 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Crystal structure of prethrombin-1. Proc.Natl.Acad.Sci.USA, 107, 2010
|
|
3WUT
| Structure basis of inactivating cell abscission | Descriptor: | Centrosomal protein of 55 kDa, GLYCEROL, Inactive serine/threonine-protein kinase TEX14 | Authors: | Kim, H.J, Matsuura, A, Lee, H.H. | Deposit date: | 2014-05-05 | Release date: | 2015-07-15 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (2.301 Å) | Cite: | Structural and biochemical insights into the role of testis-expressed gene 14 (TEX14) in forming the stable intercellular bridges of germ cells. Proc.Natl.Acad.Sci.USA, 112, 2015
|
|
3WUV
| Structure basis of inactivating cell abscission with chimera peptide 2 | Descriptor: | Centrosomal protein of 55 kDa, peptide from Programmed cell death 6-interacting protein | Authors: | Kim, H.J, Matsuura, A, Lee, H.H. | Deposit date: | 2014-05-05 | Release date: | 2015-07-15 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.79 Å) | Cite: | Structural and biochemical insights into the role of testis-expressed gene 14 (TEX14) in forming the stable intercellular bridges of germ cells. Proc.Natl.Acad.Sci.USA, 112, 2015
|
|
3W8L
| Crystal structure of human CK2 in complex with inositol hexakisphosphate | Descriptor: | Casein kinase II subunit alpha, INOSITOL HEXAKISPHOSPHATE | Authors: | Son, S.H, Lee, W.-K, Yu, Y.G, Lee, H.H. | Deposit date: | 2013-03-15 | Release date: | 2013-11-13 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structural and functional insights into the regulation mechanism of CK2 by IP6 and the intrinsically disordered protein Nopp140 Proc.Natl.Acad.Sci.USA, 110, 2013
|
|
3WUU
| |
1XCU
| oligonucleotid/drug complex | Descriptor: | 1,5-BIS[3-(DIETHYLAMINO)PROPIONAMIDO]ANTHRACENE-9,10-DIONE, 5'-D(*CP*GP*TP*AP*CP*G)-3', BARIUM ION, ... | Authors: | Valls, N, Steiner, R.A, Wright, G, Murshudov, G.N, Subirana, J.A. | Deposit date: | 2004-09-03 | Release date: | 2005-07-19 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Variable role of ions in two drug intercalation complexes of DNA J.Biol.Inorg.Chem., 10, 2005
|
|
2HWL
| Crystal structure of thrombin in complex with fibrinogen gamma' peptide | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Fibrinogen gamma' peptide, Prothrombin, ... | Authors: | Pineda, A.O, Chen, Z.W, Marino, F, Mathews, F.S, Mosesson, M.W, Di Cera, E. | Deposit date: | 2006-08-01 | Release date: | 2006-09-19 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Crystal structure of thrombin in complex with fibrinogen gamma' peptide. Biophys.Chem., 125, 2007
|
|
1DET
| RIBONUCLEASE T1 CARBOXYMETHYLATED AT GLU 58 IN COMPLEX WITH 2'GMP | Descriptor: | GUANOSINE-2'-MONOPHOSPHATE, RIBONUCLEASE T1, SODIUM ION | Authors: | Ishikawa, K, Suzuki, E, Tanokura, M, Takahashi, K. | Deposit date: | 1996-02-20 | Release date: | 1996-07-11 | Last modified: | 2024-06-05 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Crystal structure of ribonuclease T1 carboxymethylated at Glu58 in complex with 2'-GMP. Biochemistry, 35, 1996
|
|
2YEN
| Solution structure of the skeletal muscle and neuronal voltage gated sodium channel antagonist mu-conotoxin CnIIIC | Descriptor: | Mu-conotoxin CnIIIC | Authors: | Favreau, P, Benoit, E, Hocking, H.G, Carlier, L, D'hoedt, D, Leipold, E, Markgraf, R, Schlumberger, S, Cordova, M.A, Gaertner, H, Paolini-Bertrand, M, Hartley, O, Tytgat, J, Heinemann, S.H, Bertrand, D, Boelens, R, Stocklin, R, Molgo, J. | Deposit date: | 2011-03-28 | Release date: | 2012-02-08 | Last modified: | 2023-06-14 | Method: | SOLUTION NMR | Cite: | A Novel Mu-Conopeptide, Cniiic, Exerts Potent and Preferential Inhibition of Na(V) 1.2/1.4 Channels and Blocks Neuronal Nicotinic Acetylcholine Receptors. Br.J.Pharmacol., 166, 2012
|
|
2YEO
| A39L mutation of scorpion toxin lqh-alpha-it | Descriptor: | 1,2-ETHANEDIOL, ALPHA-INSECT TOXIN LQHAIT, CHLORIDE ION, ... | Authors: | Frolow, F, Kahn, R, Gurevitz, M. | Deposit date: | 2011-03-28 | Release date: | 2011-04-13 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.08 Å) | Cite: | Crystal Structures of Scorpion Alpha-Toxinsmutants Reveal Conformational Constraints that Dictate Preference for Mammalian Brain Voltage-Gated Na- Channels To be Published
|
|
3B26
| Hsp90 alpha N-terminal domain in complex with an inhibitor Ro1127850 | Descriptor: | 4-(1H,3H-benzo[de]isochromen-6-yl)-6-methylpyrimidin-2-amine, Heat shock protein HSP 90-alpha | Authors: | Fukami, T.A, Ono, N. | Deposit date: | 2011-07-21 | Release date: | 2011-09-14 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Lead generation of heat shock protein 90 inhibitors by a combination of fragment-based approach, virtual screening, and structure-based drug design Bioorg.Med.Chem.Lett., 21, 2011
|
|
3B24
| Hsp90 alpha N-terminal domain in complex with an aminotriazine fragment molecule | Descriptor: | 4-(ethylsulfanyl)-6-methyl-1,3,5-triazin-2-amine, Heat shock protein HSP 90-alpha, MAGNESIUM ION | Authors: | Fukami, T.A, Ono, N. | Deposit date: | 2011-07-21 | Release date: | 2011-09-14 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Lead generation of heat shock protein 90 inhibitors by a combination of fragment-based approach, virtual screening, and structure-based drug design Bioorg.Med.Chem.Lett., 21, 2011
|
|
3B27
| Hsp90 alpha N-terminal domain in complex with an inhibitor Ro4919127 | Descriptor: | 4-(2-chlorophenyl)-6-(methylsulfanyl)-1,3,5-triazin-2-amine, Heat shock protein HSP 90-alpha | Authors: | Fukami, T.A, Ono, N. | Deposit date: | 2011-07-21 | Release date: | 2011-09-14 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Lead generation of heat shock protein 90 inhibitors by a combination of fragment-based approach, virtual screening, and structure-based drug design Bioorg.Med.Chem.Lett., 21, 2011
|
|
3B25
| Hsp90 alpha N-terminal domain in complex with an inhibitor CH4675194 | Descriptor: | 4-Methyl-6-(toluene-4-sulfonyl)-pyrimidin-2-ylamine, Heat shock protein HSP 90-alpha | Authors: | Fukami, T.A, Ono, N. | Deposit date: | 2011-07-21 | Release date: | 2011-09-14 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Lead generation of heat shock protein 90 inhibitors by a combination of fragment-based approach, virtual screening, and structure-based drug design Bioorg.Med.Chem.Lett., 21, 2011
|
|
1DBI
| CRYSTAL STRUCTURE OF A THERMOSTABLE SERINE PROTEASE | Descriptor: | AK.1 SERINE PROTEASE, CALCIUM ION, SODIUM ION | Authors: | Smith, C.A, Toogood, H.S, Baker, H.M, Daniel, R.M, Baker, E.N. | Deposit date: | 1999-11-02 | Release date: | 1999-11-18 | Last modified: | 2017-10-04 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Calcium-mediated thermostability in the subtilisin superfamily: the crystal structure of Bacillus Ak.1 protease at 1.8 A resolution. J.Mol.Biol., 294, 1999
|
|
4NX1
| Crystal structure of a trap periplasmic solute binding protein from Sulfitobacter sp. nas-14.1, target EFI-510292, with bound alpha-D-taluronate | Descriptor: | C4-dicarboxylate transport system substrate-binding protein, alpha-D-talopyranuronic acid | Authors: | Vetting, M.W, Al Obaidi, N.F, Morisco, L.L, Wasserman, S.R, Sojitra, S, Stead, M, Attonito, J.D, Scott Glenn, A, Chowdhury, S, Evans, B, Hillerich, B, Love, J, Seidel, R.D, Imker, H.J, Gerlt, J.A, Almo, S.C, Enzyme Function Initiative (EFI) | Deposit date: | 2013-12-08 | Release date: | 2014-01-22 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Experimental strategies for functional annotation and metabolism discovery: targeted screening of solute binding proteins and unbiased panning of metabolomes. Biochemistry, 54, 2015
|
|
7KDT
| |
4PF8
| CRYSTAL STRUCTURE OF A TRAP PERIPLASMIC SOLUTE BINDING PROTEIN FROM SULFITOBACTER sp. NAS-14.1 (TARGET EFI-510299) WITH BOUND BETA-D-GALACTURONATE | Descriptor: | CHLORIDE ION, TRAP-T family transporter, DctP (Periplasmic binding) subunit, ... | Authors: | Vetting, M.W, Al Obaidi, N.F, Morisco, L.L, Wasserman, S.R, Stead, M, Attonito, J.D, Scott Glenn, A, Chowdhury, S, Evans, B, Hillerich, B, Love, J, Seidel, R.D, Whalen, K.L, Gerlt, J.A, Almo, S.C, Enzyme Function Initiative (EFI) | Deposit date: | 2014-04-28 | Release date: | 2014-05-14 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Experimental strategies for functional annotation and metabolism discovery: targeted screening of solute binding proteins and unbiased panning of metabolomes. Biochemistry, 54, 2015
|
|
3HP5
| Crystal Structure of Human p38alpha complexed with a pyrimidopyridazinone compound | Descriptor: | 2-fluoro-4-[4-(4-fluorophenyl)-1H-pyrazol-3-yl]pyridine, 5-(2,6-dichlorophenyl)-2-[(2,4-difluorophenyl)sulfanyl]-6H-pyrimido[1,6-b]pyridazin-6-one, Mitogen-activated protein kinase 14 | Authors: | Shieh, H.-S, Williams, J.M, Stegeman, R.A, Kurumbail, R.G. | Deposit date: | 2009-06-03 | Release date: | 2009-09-29 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Discovery of N-substituted pyridinones as potent and selective inhibitors of p38 kinase. Bioorg.Med.Chem.Lett., 19, 2009
|
|