2YEN

Solution structure of the skeletal muscle and neuronal voltage gated sodium channel antagonist mu-conotoxin CnIIIC

Summary for 2YEN

• Entry DOI: 10.2210/pdb2yen/pdb
• Descriptor: Mu-conotoxin CnIIIC (1 entity in total)
• Functional Keywords: toxin, conotoxin, neurotoxin, amidated c-terminus
• Biological source: Conus consors (Singed cone)
• Total number of polymer chains: 1
• Total formula weight: 2385.78

Authors

Favreau, P.,Benoit, E.,Hocking, H.G.,Carlier, L.,D'hoedt, D.,Leipold, E.,Markgraf, R.,Schlumberger, S.,Cordova, M.A.,Gaertner, H.,Paolini-Bertrand, M.,Hartley, O.,Tytgat, J.,Heinemann, S.H.,Bertrand, D.,Boelens, R.,Stocklin, R.,Molgo, J. (deposition date: 2011-03-28, release date: 2012-02-08, Last modification date: 2024-11-06)

Primary citation

Favreau, P.,Benoit, E.,Hocking, H.G.,Carlier, L.,D'Hoedt, D.,Leipold, E.,Markgraf, R.,Schlumberger, S.,Cordova, M.A.,Gaertner, H.,Paolini-Bertrand, M.,Hartley, O.,Tytgat, J.,Heinemann, S.H.,Bertrand, D.,Boelens, R.,Stocklin, R.,Molgo, J.
A Novel Mu-Conopeptide, Cniiic, Exerts Potent and Preferential Inhibition of Na(V) 1.2/1.4 Channels and Blocks Neuronal Nicotinic Acetylcholine Receptors.
Br.J.Pharmacol., 166:1654-, 2012

PubMed Abstract: The µ-conopeptide family is defined by its ability to block voltage-gated sodium channels (VGSCs), a property that can be used for the development of myorelaxants and analgesics. We characterized the pharmacology of a new µ-conopeptide (µ-CnIIIC) on a range of preparations and molecular targets to assess its potential as a myorelaxant.

PubMed: 22229737
DOI: 10.1111/J.1476-5381.2012.01837.X

Experimental method

SOLUTION NMR