3B28

Hsp90 alpha N-terminal domain in complex with an inhibitor CH5015765

Summary for 3B28
Related3B24 3B25 3B26 3B27
DescriptorHeat shock protein HSP 90-alpha, GLYCEROL, 4-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-6-(methylsulfanyl)-1,3,5-triazin-2-amine, ... (5 entities in total)
Functional Keywordschaperone-chaperone inhibitor complex, chaperone/chaperone inhibitor
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm: P07900
Total number of polymer chains2
Total formula weight52406.27
Authors
Fukami, T.A.,Ono, N. (deposition date: 2011-07-21, release date: 2011-09-14, Last modification date: 2013-06-19)
Primary citationAoki, Y.,Fukami, T.A.,Hasegawa, K.,Kim, S.J.,Miura, T.,Na, Y.J.,Ono, N.,Shimma, N.,Shindo, H.,Shiratori, Y.,Suda, A.,Tsukuda, T.,Yoon, D.O.
Lead generation of heat shock protein 90 inhibitors by a combination of fragment-based approach, virtual screening, and structure-based drug design
Bioorg.Med.Chem.Lett., 21:5778-5783, 2011
PubMed: 21875802
DOI: 110.1016/j.bmcl.2011.08.001
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.35 Å)
Structure validation
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178938

PDB entries from 2021-06-16