3B28

Hsp90 alpha N-terminal domain in complex with an inhibitor CH5015765

Summary for 3B28

• Entry DOI: 10.2210/pdb3b28/pdb
• Related: 3B24 3B25 3B26 3B27
• Descriptor: Heat shock protein HSP 90-alpha, GLYCEROL, 4-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-6-(methylsulfanyl)-1,3,5-triazin-2-amine, ... (5 entities in total)
• Functional Keywords: chaperone-chaperone inhibitor complex, chaperone/chaperone inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm: P07900
• Total number of polymer chains: 2
• Total formula weight: 52406.27

Authors

Fukami, T.A.,Ono, N. (deposition date: 2011-07-21, release date: 2011-09-14, Last modification date: 2024-03-13)

• Primary citation: Miura, T.,Fukami, T.A.,Hasegawa, K.,Ono, N.,Suda, A.,Shindo, H.,Yoon, D.O.,Kim, S.J.,Na, Y.J.,Aoki, Y.,Shimma, N.,Tsukuda, T.,Shiratori, Y.; Lead generation of heat shock protein 90 inhibitors by a combination of fragment-based approach, virtual screening, and structure-based drug design; Bioorg.Med.Chem.Lett., 21:5778-5783, 2011; PubMed: 21875802; DOI: 10.1016/j.bmcl.2011.08.001

Experimental method

X-RAY DIFFRACTION (1.35 Å)