3B24
Hsp90 alpha N-terminal domain in complex with an aminotriazine fragment molecule
Summary for 3B24
| Entry DOI | 10.2210/pdb3b24/pdb |
| Related | 3B25 3B26 3B27 3B28 |
| Descriptor | Heat shock protein HSP 90-alpha, MAGNESIUM ION, 4-(ethylsulfanyl)-6-methyl-1,3,5-triazin-2-amine, ... (4 entities in total) |
| Functional Keywords | chaperone-chaperone inhibitor complex, chaperone/chaperone inhibitor |
| Biological source | Homo sapiens (human) |
| Cellular location | Cytoplasm : P07900 |
| Total number of polymer chains | 2 |
| Total formula weight | 51940.71 |
| Authors | Fukami, T.A.,Ono, N. (deposition date: 2011-07-21, release date: 2011-09-14, Last modification date: 2024-03-13) |
| Primary citation | Miura, T.,Fukami, T.A.,Hasegawa, K.,Ono, N.,Suda, A.,Shindo, H.,Yoon, D.O.,Kim, S.J.,Na, Y.J.,Aoki, Y.,Shimma, N.,Tsukuda, T.,Shiratori, Y. Lead generation of heat shock protein 90 inhibitors by a combination of fragment-based approach, virtual screening, and structure-based drug design Bioorg.Med.Chem.Lett., 21:5778-5783, 2011 Cited by PubMed: 21875802DOI: 10.1016/j.bmcl.2011.08.001 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.7 Å) |
Structure validation
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