PDB: 26577 resultsInfo pagesStatus searchChemie searchBIRD

---

6UIF	Discovery of fragment-inspired heterocyclic benzenesulfonmides as inhibitors of the WDR5-MYC interaction Descriptor: 4-{[(5-bromo-3-chloro-2-hydroxyphenyl)sulfonyl]amino}-1-cyclopentyl-N-methyl-1H-imidazole-2-carboxamide, WD repeat domain 5 Authors: Zhao, B. Deposit date: 2019-09-30 Release date: 2020-04-15 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.603 Å) Cite: Discovery of WD Repeat-Containing Protein 5 (WDR5)-MYC Inhibitors Using Fragment-Based Methods and Structure-Based Design. J.Med.Chem., 63, 2020
3SMR	Crystal structure of human WD repeat domain 5 with compound Descriptor: 1,2-ETHANEDIOL, 2-chloro-N-[2-(4-methylpiperazin-1-yl)-5-nitrophenyl]benzamide, UNKNOWN ATOM OR ION, ... Authors: Dong, A, Dombrovski, L, Wasney, G.A, Tempel, W, Senisterra, G, Bolshan, Y, Smil, D, Nguyen, K.T, Hajian, T, Poda, G, Al-Awar, R, Bountra, C, Weigelt, J, Edwards, A.M, Brown, P.J, Schapira, M, Arrowsmith, C.H, Vedadi, M, Wu, H, Structural Genomics Consortium (SGC) Deposit date: 2011-06-28 Release date: 2011-08-31 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.82 Å) Cite: Small-molecule inhibition of MLL activity by disruption of its interaction with WDR5. Biochem. J., 449, 2013
6U5Y	Discovery and optimization of salicyclic acid-derived sulfonamide inhibitors of the WDR5:MYC protein-protein interaction Descriptor: 3-{[(5-bromo-3-chloro-2-hydroxyphenyl)sulfonyl]amino}-5-(1-cyanocyclobutyl)-2-hydroxy-N-methylbenzamide, WD repeat-containing protein 5 Authors: Zhao, B, Wang, F. Deposit date: 2019-08-28 Release date: 2019-12-04 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.532 Å) Cite: Discovery and Optimization of Salicylic Acid-Derived Sulfonamide Inhibitors of the WD Repeat-Containing Protein 5-MYC Protein-Protein Interaction. J.Med.Chem., 62, 2019
6UJH	Discovery of fragment-inspired heterocyclic benzenesulfonamides as inhibitors of the WDR5-MYC interaction Descriptor: (2R)-2-(4-chlorophenyl)-3-oxobutanenitrile, DIMETHYL SULFOXIDE, SULFATE ION, ... Authors: Phan, J, Fesik, S.W. Deposit date: 2019-10-03 Release date: 2020-04-15 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.493 Å) Cite: Discovery of WD Repeat-Containing Protein 5 (WDR5)-MYC Inhibitors Using Fragment-Based Methods and Structure-Based Design. J.Med.Chem., 63, 2020
6U5M	Discovery and optimization of salicyclic acid-derived sulfonamide inhibitors of the WDR5:MYC protein-protein interaction Descriptor: 5-bromo-2-hydroxy-N-[3-(methylsulfonyl)-5-(pentafluoro-lambda~6~-sulfanyl)phenyl]benzene-1-sulfonamide, WD repeat-containing protein 5 Authors: Zhao, B, Wang, F. Deposit date: 2019-08-28 Release date: 2019-12-04 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Discovery and Optimization of Salicylic Acid-Derived Sulfonamide Inhibitors of the WD Repeat-Containing Protein 5-MYC Protein-Protein Interaction. J.Med.Chem., 62, 2019
6U8B	Discovery and optimization of salicyclic acid-derived sulfonamide inhibitors of the WDR5:MYC protein-protein interaction Descriptor: 3-{[(5-bromo-2-methoxyphenyl)sulfonyl]amino}-5-chloro-2-hydroxybenzoic acid, WD repeat-containing protein 5 Authors: Zhao, B, Wang, F. Deposit date: 2019-09-04 Release date: 2019-12-04 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.261 Å) Cite: Discovery and Optimization of Salicylic Acid-Derived Sulfonamide Inhibitors of the WD Repeat-Containing Protein 5-MYC Protein-Protein Interaction. J.Med.Chem., 62, 2019
6U6W	Discovery and optimization of salicyclic acid-derived sulfonamide inhibitors of the WDR5:MYC protein-protein interaction Descriptor: 5-bromo-N-(5-chloro-2-hydroxyphenyl)-2-methoxybenzene-1-sulfonamide, WD repeat-containing protein 5 Authors: Zhao, B, Wang, F. Deposit date: 2019-08-30 Release date: 2019-12-04 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.2 Å) Cite: Discovery and Optimization of Salicylic Acid-Derived Sulfonamide Inhibitors of the WD Repeat-Containing Protein 5-MYC Protein-Protein Interaction. J.Med.Chem., 62, 2019
6UGH	Cryo-EM structure of the apo form of human PRMT5:MEP50 complex at a resolution of 3.4 angstrom Descriptor: Methylosome protein 50, Protein arginine N-methyltransferase 5 Authors: Zhou, W, Yadav, G.P, Jiang, Q.-X, Li, C. Deposit date: 2019-09-26 Release date: 2020-12-09 Last modified: 2024-03-20 Method: ELECTRON MICROSCOPY (3.4 Å) Cite: A 3.4-angstrom cryo-EM structure of the apo form of hu-man PRMT5:MEP50 complex reveals sequential catalysis of symmetric methyl transfer To Be Published
6U7C	Human GRK2 in complex with Gbetagamma subunits and CCG258747 Descriptor: 5-[(3S,4R)-3-{[(2H-1,3-benzodioxol-5-yl)oxy]methyl}piperidin-4-yl]-2-fluoro-N-[(2H-indazol-3-yl)methyl]benzamide, Beta-adrenergic receptor kinase 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... Authors: Bouley, R, Tesmer, J.J.G. Deposit date: 2019-09-02 Release date: 2020-04-15 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.44 Å) Cite: A New Paroxetine-Based GRK2 Inhibitor Reduces Internalization of themu-Opioid Receptor. Mol.Pharmacol., 97, 2020
6U8L	Discovery and optimization of salicyclic acid-derived sulfonamide inhibitors of the WDR5:MYC protein-protein interaction Descriptor: 3-{[(5-bromo-2-hydroxyphenyl)sulfonyl]amino}-5-cyclopropyl-6-fluoro-2-hydroxybenzoic acid, N-[2-(4-methylpiperazin-1-yl)-5-nitrophenyl]isoquinolin-1-amine, WD repeat-containing protein 5 Authors: Zhao, B, Wang, F. Deposit date: 2019-09-05 Release date: 2019-12-04 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.57 Å) Cite: Discovery and Optimization of Salicylic Acid-Derived Sulfonamide Inhibitors of the WD Repeat-Containing Protein 5-MYC Protein-Protein Interaction. J.Med.Chem., 62, 2019
6U8O	Discovery and optimization of salicyclic acid-derived sulfonamide inhibitors of the WDR5:MYC protein-protein interaction Descriptor: 5-bromo-N-[5-(1-cyanocyclobutyl)-2-hydroxyphenyl]-2-hydroxybenzene-1-sulfonamide, WD repeat-containing protein 5 Authors: Zhao, B, Wang, F. Deposit date: 2019-09-05 Release date: 2019-12-04 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Discovery and Optimization of Salicylic Acid-Derived Sulfonamide Inhibitors of the WD Repeat-Containing Protein 5-MYC Protein-Protein Interaction. J.Med.Chem., 62, 2019
6UJ4	Discovery of fragment-inspired heterocyclic benzenesulfonmides as inhibitors of the WDR5-MYC interaction Descriptor: 5-bromo-3-chloro-N-(1-cyclopentyl-2-methyl-1H-imidazol-4-yl)-2-hydroxybenzene-1-sulfonamide, WD repeat domain 5 Authors: Zhao, B. Deposit date: 2019-10-02 Release date: 2020-04-15 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.53 Å) Cite: Discovery of WD Repeat-Containing Protein 5 (WDR5)-MYC Inhibitors Using Fragment-Based Methods and Structure-Based Design. J.Med.Chem., 63, 2020
6UJL	Discovery of fragment-inspired heterocyclic benzenesulfonamides as inhibitors of the WDR5-MYC interaction Descriptor: 6-methyl-3-(propylsulfanyl)-1,2,4-triazin-5-ol, WD repeat-containing protein 5 Authors: Phan, J. Deposit date: 2019-10-03 Release date: 2020-04-15 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.599 Å) Cite: Discovery of WD Repeat-Containing Protein 5 (WDR5)-MYC Inhibitors Using Fragment-Based Methods and Structure-Based Design. J.Med.Chem., 63, 2020
6V0N	PRMT5 bound to PBM peptide from Riok1 Descriptor: Methylosome protein 50, Protein arginine N-methyltransferase 5, Riok1 PBM peptide, ... Authors: McMIllan, B.J, Raymond, D.D. Deposit date: 2019-11-19 Release date: 2020-08-26 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.11 Å) Cite: Molecular basis for substrate recruitment to the PRMT5 methylosome. Mol.Cell, 81, 2021
6UXY	PRMT5:MEP50 Complexed with Allosteric Inhibitor Compound 8 Descriptor: (5R)-2-amino-5-(2-cyclohexylethyl)-3-methyl-5-phenyl-3,5-dihydro-4H-imidazol-4-one, 1,2-ETHANEDIOL, GLYCEROL, ... Authors: Palte, R.L, Schneider, S.E. Deposit date: 2019-11-08 Release date: 2020-08-19 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.57 Å) Cite: Allosteric Modulation of Protein Arginine Methyltransferase 5 (PRMT5). Acs Med.Chem.Lett., 11, 2020
6V8I	Composite atomic model of the Staphylococcus aureus phage 80alpha baseplate Descriptor: Distal Tail Protein, gp58, FE (III) ION, ... Authors: Kizziah, J.L, Dokland, T. Deposit date: 2019-12-11 Release date: 2020-03-04 Last modified: 2024-03-06 Method: ELECTRON MICROSCOPY (3.7 Å) Cite: Structure of the host cell recognition and penetration machinery of a Staphylococcus aureus bacteriophage. Plos Pathog., 16, 2020
6VE7	The inner junction complex of Chlamydomonas reinhardtii doublet microtubule Descriptor: Cilia- and flagella-associated protein 20, FAP276, FAP52, ... Authors: Khalifa, A.A.Z, Ichikawa, M, Bui, K.H. Deposit date: 2019-12-30 Release date: 2020-02-05 Method: ELECTRON MICROSCOPY (3.6 Å) Cite: The inner junction complex of the cilia is an interaction hub that involves tubulin post-translational modifications. Elife, 9, 2020
4C7D	Structure and activity of the GH20 beta-N-acetylhexosaminidase from Streptomyces coelicolor A3(2) Descriptor: 1,2-ETHANEDIOL, BETA-N-ACETYLHEXOSAMINIDASE Authors: Nguyenthi, N, Offen, W.A, Davies, G.J, Doucet, N. Deposit date: 2013-09-20 Release date: 2014-03-12 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (1.85 Å) Cite: Structure and Activity of the Streptomyces Coelicolor A3(2) Beta-N-Acetylhexosaminidase Provides Further Insight Into Gh20 Family Catalysis and Inhibition. Biochemistry, 53, 2014
3TGW	Crystal structure of subunit B mutant H156A of the A1AO ATP synthase Descriptor: 2-(2-METHOXYETHOXY)ETHANOL, 3,6,9,12,15,18-HEXAOXAICOSANE-1,20-DIOL, 4-(2-AMINOETHYL)BENZENESULFONYL FLUORIDE, ... Authors: Tadwal, V.S, Manimekalai, M.S.S, Jeyakanthan, J, Gruber, G. Deposit date: 2011-08-18 Release date: 2012-09-05 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (1.75 Å) Cite: Structure of subunit A mutants H156A, N157A and N157T of the A1AO ATP synthase To be Published
6AZ1	Cryo-EM structure of the small subunit of Leishmania ribosome bound to paromomycin Descriptor: E-site tRNA, LACK1, MAGNESIUM ION, ... Authors: Shalev-Benami, M, Zhang, Y, Rozenberg, H, Matzov, D, Zimmerman, E, Bashan, A, Jaffe, C.L, Yonath, A, Skiniotis, G. Deposit date: 2017-09-09 Release date: 2017-12-06 Last modified: 2019-07-03 Method: ELECTRON MICROSCOPY (2.7 Å) Cite: Atomic resolution snapshot of Leishmania ribosome inhibition by the aminoglycoside paromomycin. Nat Commun, 8, 2017
6SV4	The cryo-EM structure of SDD1-stalled collided trisome. Descriptor: 18S rRNA, 25S rRNA, 40S ribosomal protein S0-A, ... Authors: Tesina, P, Buschauer, R, Cheng, J, Becker, T, Beckmann, R. Deposit date: 2019-09-17 Release date: 2020-03-04 Last modified: 2020-04-22 Method: ELECTRON MICROSCOPY (3.3 Å) Cite: RQT complex dissociates ribosomes collided on endogenous RQC substrate SDD1. Nat.Struct.Mol.Biol., 27, 2020
6SNT	Yeast 80S ribosome stalled on SDD1 mRNA. Descriptor: 40S ribosomal protein S0-A, 40S ribosomal protein S1-A, 40S ribosomal protein S10-A, ... Authors: Tesina, P, Buschauer, R, Cheng, J, Becker, T, Beckmann, R. Deposit date: 2019-08-27 Release date: 2020-03-04 Last modified: 2020-04-22 Method: ELECTRON MICROSCOPY (2.8 Å) Cite: RQT complex dissociates ribosomes collided on endogenous RQC substrate SDD1. Nat.Struct.Mol.Biol., 27, 2020
6SJQ	1.7-A resolution crystal structure of the N-terminal domain of T. brucei BILBO1 Descriptor: Flagellar pocket-related cytoskeletal protein, GLYCEROL Authors: Vidilaseris, K, Dong, G. Deposit date: 2019-08-13 Release date: 2020-01-01 Last modified: 2024-05-15 Method: X-RAY DIFFRACTION (1.604 Å) Cite: Crystal structure of the N-terminal domain of the trypanosome flagellar protein BILBO1 reveals a ubiquitin fold with a long structured loop for protein binding. J.Biol.Chem., 295, 2020
4AMH	Influence of circular permutation on the folding pathway of a PDZ domain Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, DISKS LARGE HOMOLOG 1, GLYCEROL Authors: Hultqvist, G, Punekar, A.S, Chi, C.N, Selmer, M, Gianni, S, Jemth, P. Deposit date: 2012-03-10 Release date: 2012-12-05 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Tolerance of Protein Folding to a Circular Permutation in a Pdz Domain Plos One, 7, 2012
4AFD	Structural and biochemical characterization of a novel Carbohydrate Binding Module of endoglucanase Cel5A from Eubacterium cellulosolvens with a partially bound cellotetraose moeity. Descriptor: ENDOGLUCANASE CEL5A, beta-D-glucopyranose-(1-4)-beta-D-glucopyranose-(1-4)-beta-D-glucopyranose-(1-4)-beta-D-glucopyranose Authors: Luis, A.S, Venditto, I, Prates, J.A.M, Ferreira, L.M.A, Gilbert, H.J, Fontes, C.M.G.A, Najmudin, S. Deposit date: 2012-01-18 Release date: 2012-12-26 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (1.34 Å) Cite: Understanding How Noncatalytic Carbohydrate Binding Modules Can Display Specificity for Xyloglucan. J.Biol.Chem., 288, 2013

<282283284285286287288289290291292293294295296297>