PDB: 222415 resultsInfo pagesStatus searchChemie searchBIRD

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4NHF	Crystal structure of the soluble domain of TrwG Type IV secretion machinery from Bartonella grahamii Descriptor: CALCIUM ION, TrwG protein Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2013-11-04 Release date: 2014-03-05 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2 Å) Cite: Structural Insight into How Bacteria Prevent Interference between Multiple Divergent Type IV Secretion Systems. MBio, 6, 2015
4NL9	Crystal structure of the human Anks3-SAM/Anks6-SAM heterodimer Descriptor: Ankyrin repeat and SAM domain-containing protein 3, Ankyrin repeat and SAM domain-containing protein 6, MAGNESIUM ION Authors: Leettola, C.N, Cascio, D, Bowie, J.U. Deposit date: 2013-11-13 Release date: 2014-07-16 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Characterization of the SAM domain of the PKD-related protein ANKS6 and its interaction with ANKS3. Bmc Struct.Biol., 14, 2014
4NGG	Structure of human Dicer Platform-PAZ-Connector Helix cassette in complex with 13-mer siRNA having 5'-A and UU-3' ends (2.6 Angstrom resolution) Descriptor: 5'-R(*AP*GP*CP*GP*AP*AP*UP*UP*CP*GP*CP*UP*U)-3', Endoribonuclease Dicer, PHOSPHATE ION Authors: Simanshu, D.K, Tian, Y, Patel, D.J. Deposit date: 2013-11-01 Release date: 2014-03-05 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.6 Å) Cite: A Phosphate-Binding Pocket within the Platform-PAZ-Connector Helix Cassette of Human Dicer. Mol.Cell, 53, 2014
4NIP	GVIGIAQ segment 147-153 from Human Superoxide Dismutase Descriptor: GVTGIAQ segment from Superoxide dismutase [Cu-Zn] Authors: Sievers, S.A, Sawaya, M.R, Eisenberg, D, Ivanova, M.I. Deposit date: 2013-11-06 Release date: 2013-12-04 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Aggregation-triggering segments of SOD1 fibril formation support a common pathway for familial and sporadic ALS. Proc.Natl.Acad.Sci.USA, 111, 2014
4NDU	Crystal structure of L. decastes alpha-galactosyl-binding lectin in complex with alpha-methylgalactoside Descriptor: Alpha-galactosyl-binding lectin, methyl alpha-D-galactopyranoside Authors: Van Eerde, A, Grahn, E, Krengel, U. Deposit date: 2013-10-27 Release date: 2014-12-10 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.301 Å) Cite: Atomic-resolution structure of the alpha-galactosyl binding Lyophyllum decastes lectin reveals a new protein family found in both fungi and plants. Glycobiology, 25, 2015
4NE2	Pantothenamide-bound Pantothenate Kinase from Klebsiella pneumoniae Descriptor: (R)-N-(3-((2-(benzo[d][1,3]dioxol-5-yl)ethyl)amino)-3-oxopropyl)-2,4-dihydroxy-3,3-dimethylbutanamide, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... Authors: Hughes, S.J, Antoshchenko, T, Kim, K.P, Smil, D, Park, H.W. Deposit date: 2013-10-28 Release date: 2014-02-26 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Structural characterization of a new N-substituted pantothenamide bound to pantothenate kinases from Klebsiella pneumoniae and Staphylococcus aureus. Proteins, 82, 2014
4NGC	Structure of human Dicer Platform-PAZ-Connector Helix cassette in complex with 12-mer siRNA having UA-3' ends (2.1 Angstrom resolution) Descriptor: 5'-R(*GP*CP*GP*AP*AP*UP*UP*CP*GP*CP*UP*A)-3', Endoribonuclease Dicer Authors: Simanshu, D.K, Tian, Y, Patel, D.J. Deposit date: 2013-11-01 Release date: 2014-03-05 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.104 Å) Cite: A Phosphate-Binding Pocket within the Platform-PAZ-Connector Helix Cassette of Human Dicer. Mol.Cell, 53, 2014
4NGM	Crystal Structure of Glutamate Carboxypeptidase II in a complex with urea-based inhibitor Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... Authors: Tykvart, J, Pachl, P. Deposit date: 2013-11-02 Release date: 2014-06-18 Last modified: 2020-07-29 Method: X-RAY DIFFRACTION (1.84 Å) Cite: Rational design of urea-based glutamate carboxypeptidase II (GCPII) inhibitors as versatile tools for specific drug targeting and delivery. Bioorg.Med.Chem., 22, 2014
4NH6	Structure of human Dicer Platform-PAZ-Connector Helix cassette in complex with 15-mer siRNA having 5'-pUUU and UU-3' ends (2.55 Angstrom resolution) Descriptor: 5'-R(P*UP*UP*UP*GP*CP*GP*AP*AP*UP*UP*CP*GP*CP*UP*U)-3', Endoribonuclease Dicer Authors: Simanshu, D.K, Tian, Y, Patel, D.J. Deposit date: 2013-11-04 Release date: 2014-03-05 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.551 Å) Cite: A Phosphate-Binding Pocket within the Platform-PAZ-Connector Helix Cassette of Human Dicer. Mol.Cell, 53, 2014
4NHK	Crystal structure of Tpa1p from Saccharomyces cerevisiae, termination and polyadenylation protein 1, in complex with pyridine-2,4-dicarboxylic acid (2,4-PDCA) Descriptor: GLYCEROL, MANGANESE (II) ION, PKHD-type hydroxylase TPA1, ... Authors: Scotti, J.S, McDonough, M.A, Schofield, C.J. Deposit date: 2013-11-05 Release date: 2014-11-19 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Structure of the Ribosomal Oxygenase OGFOD1 Provides Insights into the Regio- and Stereoselectivity of Prolyl Hydroxylases. Structure, 23, 2015
4NNT	Crystal structure of FABP4 in complex with novel inhibitor Descriptor: 2,4,6-tri(propan-2-yl)benzoic acid, Fatty acid-binding protein, adipocyte Authors: Liu, Q.F, Chen, T.T, Xu, Y.C. Deposit date: 2013-11-19 Release date: 2014-11-19 Last modified: 2024-03-20 Method: X-RAY DIFFRACTION (1.53 Å) Cite: The complex structure of FABP4 with novel inhibitors To be Published
4NNS	Crystal structure of FABP4 in complex with novel inhibitor Descriptor: 2,4,6-tri(propan-2-yl)benzenesulfonic acid, Fatty acid-binding protein, adipocyte Authors: Liu, Q.F, Chen, T.T, Xu, Y.C. Deposit date: 2013-11-19 Release date: 2014-11-19 Last modified: 2024-03-20 Method: X-RAY DIFFRACTION (1.53 Å) Cite: The complex structure of FABP4 with novel inhibitors To be Published
4NCA	Structure of Thermus thermophilus Argonaute bound to guide DNA 19-mer and target DNA in the presence of Mg2+ Descriptor: 5'-D(*AP*CP*AP*AP*CP*C)-3', 5'-D(P*TP*AP*CP*TP*AP*CP*CP*TP*CP*G)-3', 5'-D(P*TP*GP*AP*GP*GP*TP*AP*GP*TP*AP*GP*GP*TP*TP*GP*TP*AP*TP*AP*GP*T)-3', ... Authors: Sheng, G, Zhao, H, Wang, J, Rao, Y, Wang, Y. Deposit date: 2013-10-24 Release date: 2014-01-15 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (2.489 Å) Cite: Structure-based cleavage mechanism of Thermus thermophilus Argonaute DNA guide strand-mediated DNA target cleavage. Proc.Natl.Acad.Sci.USA, 111, 2014
4NO0	Crystal structure of non-phosphorylated form of RQA_V phosphopeptide bound to HLA-A2 in complex with LILRB1 Descriptor: 1,2-ETHANEDIOL, Beta-2-microglobulin, HLA class I histocompatibility antigen, ... Authors: Mohammed, F, Stones, D.H, Willcox, B.E. Deposit date: 2013-11-19 Release date: 2014-11-19 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.7 Å) Cite: The antigenic identity of human class I MHC phosphopeptides is critically dependent upon phosphorylation status. Oncotarget, 8, 2017
4NP5	Crystal structure of Staphylococcal nuclease variant Delta+PHS V66A/I92N at cryogenic temperature Descriptor: CALCIUM ION, THYMIDINE-3',5'-DIPHOSPHATE, Thermonuclease Authors: Caro, J.A, Nam, S, Schlessman, J.L, Heroux, A, Garcia-Moreno E, B. Deposit date: 2013-11-20 Release date: 2013-12-04 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Pressure effects in proteins To be Published
4NPC	Crystal Structure of an Oxidoreductase, Short-Chain Dehydrogenase/Reductase Family Protein from Brucella suis Descriptor: ACETATE ION, Sorbitol dehydrogenase Authors: Dranow, D.M, Davies, D.R, Edwards, T.E, Lorimer, D, Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2013-11-21 Release date: 2013-12-11 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.75 Å) Cite: Crystal Structure of an Oxidoreductase, Short-Chain Dehydrogenase/Reductase Family Protein from Brucella suis To be Published
4NR5	Crystal structure of the bromodomain of human CREBBP in complex with an isoxazolyl-benzimidazole ligand Descriptor: 1,2-ETHANEDIOL, 5-(3,5-dimethyl-1,2-oxazol-4-yl)-1-[2-(morpholin-4-yl)ethyl]-2-(2-phenylethyl)-1H-benzimidazole, CREB-binding protein, ... Authors: Filippakopoulos, P, Picaud, S, Felletar, I, Hay, D, Fedorov, O, Martin, S, Pike, A.W, von Delft, F, Brennan, P, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Knapp, S, Structural Genomics Consortium (SGC) Deposit date: 2013-11-26 Release date: 2013-12-18 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.66 Å) Cite: Crystal structure of the bromodomain of human CREBBP in complex with an isoxazolyl-benzimidazole ligand To be Published
4NGR	Crystal Structure of Glutamate Carboxypeptidase II in a complex with urea-based inhibitor Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... Authors: Tykvart, J, Pachl, P. Deposit date: 2013-11-02 Release date: 2014-06-18 Last modified: 2020-07-29 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Rational design of urea-based glutamate carboxypeptidase II (GCPII) inhibitors as versatile tools for specific drug targeting and delivery. Bioorg.Med.Chem., 22, 2014
4N7W	Crystal Structure of the sodium bile acid symporter from Yersinia frederiksenii Descriptor: CITRIC ACID, Transporter, sodium/bile acid symporter family, ... Authors: Zhou, X, Levin, E.J, Zhou, M, New York Consortium on Membrane Protein Structure (NYCOMPS) Deposit date: 2013-10-16 Release date: 2013-12-11 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.951 Å) Cite: Structural basis of the alternating-access mechanism in a bile acid transporter. Nature, 505, 2013
4NB0	Crystal Structure of FosB from Staphylococcus aureus with BS-Cys9 disulfide at 1.62 Angstrom Resolution Descriptor: CYSTEINE, GLYCEROL, Metallothiol transferase FosB, ... Authors: Thompson, M.K, Goodman, M.C, Jagessar, K, Harp, J, Keithly, M.E, Cook, P.D, Armstrong, R.N. Deposit date: 2013-10-22 Release date: 2014-02-26 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.62 Å) Cite: Structure and Function of the Genomically Encoded Fosfomycin Resistance Enzyme, FosB, from Staphylococcus aureus. Biochemistry, 53, 2014
4MW5	Trypanosoma brucei methionyl-tRNA synthetase in complex with inhibitor 1-{3-[(3-chloro-5-methoxybenzyl)amino]propyl}-3-phenylurea (Chem 1415) Descriptor: 1-{3-[(3-chloro-5-methoxybenzyl)amino]propyl}-3-phenylurea, DIMETHYL SULFOXIDE, GLYCEROL, ... Authors: Koh, C.Y, Kim, J.E, Wetzel, A.B, de van der Schueren, W.J, Shibata, S, Liu, J, Zhang, Z, Fan, E, Verlinde, C.L.M.J, Hol, W.G.J. Deposit date: 2013-09-24 Release date: 2014-04-30 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.347 Å) Cite: Structures of Trypanosoma brucei Methionyl-tRNA Synthetase with Urea-Based Inhibitors Provide Guidance for Drug Design against Sleeping Sickness. Plos Negl Trop Dis, 8, 2014
4N0Q	Crystal Structure of an ABC transporter, substrate-binding protein from Brucella melitensis 16M in complex with L-Leucine using a crystal grown in a Crystal Former (Microlytic) Descriptor: LEUCINE, Leu/Ile/Val-binding protein homolog 3 Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2013-10-02 Release date: 2013-11-06 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Crystal Structure of an ABC transporter, substrate-binding protein from Brucella melitensis 16M in complex with L-Leucine using a crystal grown in a Crystal Former (Microlytic) To be Published
4MR6	Crystal Structure of the second bromodomain of human BRD2 in complex with a quinazolinone ligand (RVX-208) Descriptor: 1,2-ETHANEDIOL, 2-[4-(2-hydroxyethoxy)-3,5-dimethylphenyl]-5,7-dimethoxyquinazolin-4(3H)-one, Bromodomain-containing protein 2, ... Authors: Filippakopoulos, P, Picaud, S, Felletar, I, Martin, S, Fedorov, O, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Weigelt, J, Bountra, C, Knapp, S, Structural Genomics Consortium (SGC) Deposit date: 2013-09-17 Release date: 2013-11-27 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.67 Å) Cite: RVX-208, an inhibitor of BET transcriptional regulators with selectivity for the second bromodomain. Proc.Natl.Acad.Sci.USA, 110, 2013
4MRF	Crystal structure of the murine cd44 hyaluronan binding domain complex with a small molecule Descriptor: 1,2,3,4-tetrahydroisoquinoline, CD44 antigen, DIMETHYL SULFOXIDE, ... Authors: Liu, L.K, Finzel, B. Deposit date: 2013-09-17 Release date: 2014-04-16 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.55 Å) Cite: Fragment-Based Identification of an Inducible Binding Site on Cell Surface Receptor CD44 for the Design of Protein-Carbohydrate Interaction Inhibitors. J.Med.Chem., 57, 2014
4N7G	Crystal structure of 14-3-3zeta in complex with a peptide derived from ExoS Descriptor: 14-3-3 protein zeta/delta, Exoenzyme S, HEXAETHYLENE GLYCOL Authors: Bier, D, Glas, A, Hahne, G, Grossmann, T, Ottmann, C. Deposit date: 2013-10-15 Release date: 2014-02-19 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.25 Å) Cite: Constrained peptides with target-adapted cross-links as inhibitors of a pathogenic protein-protein interaction. Angew.Chem.Int.Ed.Engl., 53, 2014

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