Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

4MR6

Crystal Structure of the second bromodomain of human BRD2 in complex with a quinazolinone ligand (RVX-208)

Summary for 4MR6
Entry DOI10.2210/pdb4mr6/pdb
DescriptorBromodomain-containing protein 2, 1,2-ETHANEDIOL, DIMETHYL SULFOXIDE, ... (5 entities in total)
Functional Keywordsbrd2, ring3, small molecule inhibitor, rvx-208, inhibitor complex, structural genomics consortium, sgc, transcription-transcription inhibitor complex, transcription/transcription inhibitor
Biological sourceHomo sapiens (human)
Cellular locationNucleus (Probable): P25440
Total number of polymer chains1
Total formula weight14010.15
Authors
Primary citationPicaud, S.,Wells, C.,Felletar, I.,Brotherton, D.,Martin, S.,Savitsky, P.,Diez-Dacal, B.,Philpott, M.,Bountra, C.,Lingard, H.,Fedorov, O.,Muller, S.,Brennan, P.E.,Knapp, S.,Filippakopoulos, P.
RVX-208, an inhibitor of BET transcriptional regulators with selectivity for the second bromodomain.
Proc.Natl.Acad.Sci.USA, 110:19754-19759, 2013
Cited by
PubMed: 24248379
DOI: 10.1073/pnas.1310658110
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.67 Å)
Structure validation

217705

PDB entries from 2024-03-27

PDB statisticsPDBj update infoContact PDBjnumon