6ERO
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![BU of 6ero by Molmil](/molmil-images/mine/6ero) | Structure of human TFB2M | Descriptor: | CHLORIDE ION, Dimethyladenosine transferase 2, mitochondrial,Dimethyladenosine transferase 2, ... | Authors: | Hillen, H.S, Morozov, Y.I, Sarfallah, A, Temiakov, D, Cramer, P. | Deposit date: | 2017-10-18 | Release date: | 2017-11-15 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Structural Basis of Mitochondrial Transcription Initiation. Cell, 171, 2017
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7JTP
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![BU of 7jtp by Molmil](/molmil-images/mine/7jtp) | Crystal structure of Protac MS67 in complex with the WD repeat-containing protein 5 and pVHL:ElonginC:ElonginB | Descriptor: | Elongin-B, Elongin-C, GLYCEROL, ... | Authors: | Kottur, J, Jain, R, Aggarwal, A.K. | Deposit date: | 2020-08-18 | Release date: | 2021-10-06 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.12 Å) | Cite: | A selective WDR5 degrader inhibits acute myeloid leukemia in patient-derived mouse models. Sci Transl Med, 13, 2021
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7JTO
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![BU of 7jto by Molmil](/molmil-images/mine/7jto) | Crystal structure of Protac MS33 in complex with the WD repeat-containing protein 5 and pVHL:ElonginC:ElonginB | Descriptor: | 1,2-ETHANEDIOL, 3-methyl-N-(11-{[2-(4-{[4'-(4-methylpiperazin-1-yl)-3'-{[6-oxo-4-(trifluoromethyl)-5,6-dihydropyridine-3-carbonyl]amino}[1,1'-biphenyl]-3-yl]methyl}piperazin-1-yl)ethyl]amino}-11-oxoundecanoyl)-L-valyl-(4R)-4-hydroxy-N-{[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}-L-prolinamide, Elongin-B, ... | Authors: | Kottur, J, Jain, R, Aggarwal, A.K. | Deposit date: | 2020-08-18 | Release date: | 2021-10-06 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | A selective WDR5 degrader inhibits acute myeloid leukemia in patient-derived mouse models. Sci Transl Med, 13, 2021
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6MEC
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![BU of 6mec by Molmil](/molmil-images/mine/6mec) | Structure of a group II intron retroelement after DNA integration | Descriptor: | MAGNESIUM ION, Maturase reverse transcriptase, SODIUM ION, ... | Authors: | Haack, D, Yan, X, Zhang, C, Hingey, J, Lyumkis, D, Baker, T.S, Toor, N. | Deposit date: | 2018-09-06 | Release date: | 2019-08-14 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Cryo-EM Structures of a Group II Intron Reverse Splicing into DNA. Cell, 178, 2019
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6MVP
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![BU of 6mvp by Molmil](/molmil-images/mine/6mvp) | HCV NS5B 1b N316 bound to Compound 18 | Descriptor: | (4-{[5-cyclopropyl-2-(4-fluorophenyl)-3-(methylcarbamoyl)-1-benzofuran-6-yl](methylsulfonyl)amino}phenyl)boronic acid, Genome polyprotein | Authors: | Williams, S.P, Kahler, K, Price, D.J, Peat, A.J. | Deposit date: | 2018-10-26 | Release date: | 2019-09-04 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Design of N-Benzoxaborole Benzofuran GSK8175-Optimization of Human Pharmacokinetics Inspired by Metabolites of a Failed Clinical HCV Inhibitor. J.Med.Chem., 62, 2019
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5T0I
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![BU of 5t0i by Molmil](/molmil-images/mine/5t0i) | Structural basis for dynamic regulation of the human 26S proteasome | Descriptor: | 26S protease regulatory subunit 10B, 26S protease regulatory subunit 4, 26S protease regulatory subunit 6A, ... | Authors: | Chen, S, Wu, J, Lu, Y, Ma, Y.B, Lee, B.H, Yu, Z, Ouyang, Q, Finley, D, Kirschner, M.W, Mao, Y. | Deposit date: | 2016-08-16 | Release date: | 2016-10-19 | Last modified: | 2016-11-30 | Method: | ELECTRON MICROSCOPY (8 Å) | Cite: | Structural basis for dynamic regulation of the human 26S proteasome. Proc.Natl.Acad.Sci.USA, 113, 2016
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5T0C
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![BU of 5t0c by Molmil](/molmil-images/mine/5t0c) | Structural basis for dynamic regulation of the human 26S proteasome | Descriptor: | 26S protease regulatory subunit 10B, 26S protease regulatory subunit 4, 26S protease regulatory subunit 6A, ... | Authors: | Chen, S, Wu, J, Lu, Y, Ma, Y.B, Lee, B.H, Yu, Z, Ouyang, Q, Finley, D, Kirschner, M.W, Mao, Y. | Deposit date: | 2016-08-15 | Release date: | 2016-10-19 | Last modified: | 2018-07-18 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Structural basis for dynamic regulation of the human 26S proteasome. Proc.Natl.Acad.Sci.USA, 113, 2016
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5T0J
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![BU of 5t0j by Molmil](/molmil-images/mine/5t0j) | Structural basis for dynamic regulation of the human 26S proteasome | Descriptor: | 26S protease regulatory subunit 10B, 26S protease regulatory subunit 4, 26S protease regulatory subunit 6A, ... | Authors: | Chen, S, Wu, J, Lu, Y, Ma, Y.B, Lee, B.H, Yu, Z, Ouyang, Q, Finley, D, Kirschner, M.W, Mao, Y. | Deposit date: | 2016-08-16 | Release date: | 2016-10-19 | Last modified: | 2016-11-30 | Method: | ELECTRON MICROSCOPY (8 Å) | Cite: | Structural basis for dynamic regulation of the human 26S proteasome. Proc.Natl.Acad.Sci.USA, 113, 2016
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5T0G
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![BU of 5t0g by Molmil](/molmil-images/mine/5t0g) | Structural basis for dynamic regulation of the human 26S proteasome | Descriptor: | 26S protease regulatory subunit 10B, 26S protease regulatory subunit 4, 26S protease regulatory subunit 6A, ... | Authors: | Chen, S, Wu, J, Lu, Y, Ma, Y.B, Lee, B.H, Yu, Z, Ouyang, Q, Finley, D, Kirschner, M.W, Mao, Y. | Deposit date: | 2016-08-16 | Release date: | 2016-10-19 | Last modified: | 2016-11-30 | Method: | ELECTRON MICROSCOPY (4.4 Å) | Cite: | Structural basis for dynamic regulation of the human 26S proteasome. Proc.Natl.Acad.Sci.USA, 113, 2016
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5T0H
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![BU of 5t0h by Molmil](/molmil-images/mine/5t0h) | Structural basis for dynamic regulation of the human 26S proteasome | Descriptor: | 26S protease regulatory subunit 10B, 26S protease regulatory subunit 4, 26S protease regulatory subunit 6A, ... | Authors: | Chen, S, Wu, J, Lu, Y, Ma, Y.B, Lee, B.H, Yu, Z, Ouyang, Q, Finley, D, Kirschner, M.W, Mao, Y. | Deposit date: | 2016-08-16 | Release date: | 2016-10-19 | Last modified: | 2016-11-30 | Method: | ELECTRON MICROSCOPY (6.8 Å) | Cite: | Structural basis for dynamic regulation of the human 26S proteasome. Proc.Natl.Acad.Sci.USA, 113, 2016
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1QE1
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![BU of 1qe1 by Molmil](/molmil-images/mine/1qe1) | CRYSTAL STRUCTURE OF 3TC-RESISTANT M184I MUTANT OF HIV-1 REVERSE TRANSCRIPTASE | Descriptor: | REVERSE TRANSCRIPTASE, SUBUNIT P51, SUBUNIT P66 | Authors: | Sarafianos, S.G, Das, K, Ding, J, Hughes, S.H, Arnold, E. | Deposit date: | 1999-07-12 | Release date: | 1999-08-30 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.85 Å) | Cite: | Lamivudine (3TC) resistance in HIV-1 reverse transcriptase involves steric hindrance with beta-branched amino acids. Proc.Natl.Acad.Sci.USA, 96, 1999
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5C9H
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![BU of 5c9h by Molmil](/molmil-images/mine/5c9h) | Structural Basis of Template Boundary Definition in Tetrahymena Telomerase | Descriptor: | MAGNESIUM ION, RNA (5'-R(P*AP*GP*AP*AP*CP*UP*GP*UP*CP*A)-3'), RNA (5'-R(P*UP*CP*AP*UP*UP*CP*AP*GP*UP*UP*CP*U)-3'), ... | Authors: | Jansson, L.I, Akiyama, B.M, Ooms, A, Lu, C, Rubin, S.M, Stone, M.D. | Deposit date: | 2015-06-26 | Release date: | 2015-10-14 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Structural basis of template-boundary definition in Tetrahymena telomerase. Nat.Struct.Mol.Biol., 22, 2015
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2FSM
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![BU of 2fsm by Molmil](/molmil-images/mine/2fsm) | |
2FST
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![BU of 2fst by Molmil](/molmil-images/mine/2fst) | |
7PI4
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![BU of 7pi4 by Molmil](/molmil-images/mine/7pi4) | FAK Protac GSK215 in complex with FAK and pVHL:ElonginC:ElonginB | Descriptor: | (2S,4R)-4-hydroxy-1-((S)-2-(2-(4-(3-methoxy-4-((4-((2-(methylcarbamoyl)phenyl)amino)-5-(trifluoromethyl)pyridin-2-yl)amino)phenyl)piperazin-1-yl)acetamido)-3,3-dimethylbutanoyl)-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide, 1,2-ETHANEDIOL, CALCIUM ION, ... | Authors: | Chung, C. | Deposit date: | 2021-08-19 | Release date: | 2021-09-29 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.24 Å) | Cite: | Discovery and Characterisation of Highly Cooperative FAK-Degrading PROTACs. Angew.Chem.Int.Ed.Engl., 60, 2021
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7PVU
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![BU of 7pvu by Molmil](/molmil-images/mine/7pvu) | Crystal structure of p38alpha C162S in complex with CAS2094511-69-8, P 1 21 1 | Descriptor: | Mitogen-activated protein kinase 14, N-(2-cyclobutyl-1H-1,3-benzodiazol-5-yl)-2-fluorobenzene-1-sulfonamide | Authors: | Baginski, B, Pous, J, Gonzalez, L, Macias, M.J, Nebreda, A.R. | Deposit date: | 2021-10-05 | Release date: | 2023-05-17 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.154 Å) | Cite: | Characterization of p38 alpha autophosphorylation inhibitors that target the non-canonical activation pathway. Nat Commun, 14, 2023
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6SIS
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![BU of 6sis by Molmil](/molmil-images/mine/6sis) | Crystal structure of macrocyclic PROTAC 1 in complex with the second bromodomain of human Brd4 and pVHL:ElonginC:ElonginB | Descriptor: | Bromodomain-containing protein 4, Elongin-B, Elongin-C, ... | Authors: | Hughes, S.J, Testa, A, Ciulli, A. | Deposit date: | 2019-08-10 | Release date: | 2019-12-04 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (3.5 Å) | Cite: | Structure-Based Design of a Macrocyclic PROTAC. Angew.Chem.Int.Ed.Engl., 59, 2020
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7PMK
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![BU of 7pmk by Molmil](/molmil-images/mine/7pmk) | S. cerevisiae replisome-SCF(Dia2) complex bound to double-stranded DNA (conformation I) | Descriptor: | Cell division control protein 45,Cell division control protein 45, Chromosome segregation in meiosis protein 3, DNA helicase, ... | Authors: | Jenkyn-Bedford, M, Yeeles, J.T.P, Deegan, T.D. | Deposit date: | 2021-09-02 | Release date: | 2021-11-10 | Last modified: | 2024-07-17 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | A conserved mechanism for regulating replisome disassembly in eukaryotes. Nature, 600, 2021
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7PMN
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![BU of 7pmn by Molmil](/molmil-images/mine/7pmn) | S. cerevisiae replisome-SCF(Dia2) complex bound to double-stranded DNA (conformation II) | Descriptor: | Cell division control protein 45,Cell division control protein 45, Chromosome segregation in meiosis protein 3, DNA polymerase alpha-binding protein, ... | Authors: | Jenkyn-Bedford, M, Yeeles, J.T.P, Deegan, T.D. | Deposit date: | 2021-09-02 | Release date: | 2021-11-10 | Last modified: | 2024-07-17 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | A conserved mechanism for regulating replisome disassembly in eukaryotes. Nature, 600, 2021
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6TPA
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![BU of 6tpa by Molmil](/molmil-images/mine/6tpa) | CDK8/CyclinC in complex with drug ETP-50775 | Descriptor: | (2~{R})-butane-1,2-diol, 1-[4-chloranyl-3-(trifluoromethyl)phenyl]-3-(5-oxidanylidene-6-pyridin-4-yl-pyrido[2,3-b][1,5]benzoxazepin-9-yl)urea, Cyclin-C, ... | Authors: | Munoz, I.G, Pastor, J, Martinez, S. | Deposit date: | 2019-12-12 | Release date: | 2020-11-18 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Pyrido[2,3-b][1,5]benzoxazepin-5(6H)-one derivatives as CDK8 inhibitors. Eur.J.Med.Chem., 201, 2020
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6QTJ
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![BU of 6qtj by Molmil](/molmil-images/mine/6qtj) | Crystal structure of human CDK8/CYCC in complex with BI 919811 | Descriptor: | Cyclin-C, Cyclin-dependent kinase 8, ~{N},~{N}-dimethyl-2-[4-[4-(2,6-naphthyridin-4-yl)phenyl]pyrazol-1-yl]ethanamide | Authors: | Boettcher, J. | Deposit date: | 2019-02-25 | Release date: | 2020-03-18 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.48 Å) | Cite: | Selective and Potent CDK8/19 Inhibitors Enhance NK-Cell Activity and Promote Tumor Surveillance. Mol.Cancer Ther., 19, 2020
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6QTG
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![BU of 6qtg by Molmil](/molmil-images/mine/6qtg) | Crystal structure of human CDK8/CYCC in complex with BI-1347 | Descriptor: | 2-[4-(4-isoquinolin-4-ylphenyl)pyrazol-1-yl]-~{N},~{N}-dimethyl-ethanamide, Cyclin-C, Cyclin-dependent kinase 8 | Authors: | Boettcher, J. | Deposit date: | 2019-02-25 | Release date: | 2020-03-18 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Selective and Potent CDK8/19 Inhibitors Enhance NK-Cell Activity and Promote Tumor Surveillance. Mol.Cancer Ther., 19, 2020
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6ME0
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![BU of 6me0 by Molmil](/molmil-images/mine/6me0) | Structure of a group II intron retroelement prior to DNA integration | Descriptor: | MAGNESIUM ION, Maturase reverse transcriptase, SODIUM ION, ... | Authors: | Haack, D, Yan, X, Zhang, C, Hingey, J, Lyumkis, D, Baker, T.S, Toor, N. | Deposit date: | 2018-09-05 | Release date: | 2019-08-14 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Cryo-EM Structures of a Group II Intron Reverse Splicing into DNA. Cell, 178, 2019
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4WBB
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![BU of 4wbb by Molmil](/molmil-images/mine/4wbb) | Single Turnover Autophosphorylation Cycle of the PKA RIIb Holoenzyme | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, CALCIUM ION, cAMP-dependent protein kinase catalytic subunit alpha, ... | Authors: | Zhang, P, Knape, M.J, Ahuja, L.G, Keshwani, M.M, King, C.C, Sastri, M, Herberg, F.W, Taylor, S.S. | Deposit date: | 2014-09-02 | Release date: | 2015-05-20 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Single Turnover Autophosphorylation Cycle of the PKA RII beta Holoenzyme. Plos Biol., 13, 2015
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8PTO
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![BU of 8pto by Molmil](/molmil-images/mine/8pto) | Structure of Rho pentamer in complex with Rof and ADP | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Protein rof, Transcription termination factor Rho | Authors: | Said, N, Hilal, T, Wahl, M.C. | Deposit date: | 2023-07-14 | Release date: | 2024-04-17 | Last modified: | 2024-04-24 | Method: | ELECTRON MICROSCOPY (2.7 Å) | Cite: | Sm-like protein Rof inhibits transcription termination factor rho by binding site obstruction and conformational insulation. Nat Commun, 15, 2024
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