6MVP

HCV NS5B 1b N316 bound to Compound 18

Summary for 6MVP

• Entry DOI: 10.2210/pdb6mvp/pdb
• Related: 6MVK 6MVO 6MVQ
• Descriptor: Genome polyprotein, (4-{[5-cyclopropyl-2-(4-fluorophenyl)-3-(methylcarbamoyl)-1-benzofuran-6-yl](methylsulfonyl)amino}phenyl)boronic acid (3 entities in total)
• Functional Keywords: hepatitus c, ns5b, viral protein
• Biological source: Hepatitis C virus genotype 1b (isolate BK) (HCV)
• Total number of polymer chains: 2
• Total formula weight: 130312.92

Authors

Williams, S.P.,Kahler, K.,Price, D.J.,Peat, A.J. (deposition date: 2018-10-26, release date: 2019-09-04, Last modification date: 2024-03-13)

• Primary citation: Chong, P.Y.,Shotwell, J.B.,Miller, J.,Price, D.J.,Maynard, A.,Voitenleitner, C.,Mathis, A.,Williams, S.,Pouliot, J.J.,Creech, K.,Wang, F.,Fang, J.,Zhang, H.,Tai, V.W.,Turner, E.,Kahler, K.M.,Crosby, R.,Peat, A.J.; Design of N-Benzoxaborole Benzofuran GSK8175-Optimization of Human Pharmacokinetics Inspired by Metabolites of a Failed Clinical HCV Inhibitor.; J.Med.Chem., 62:3254-3267, 2019; PubMed: 30763090; DOI: 10.1021/acs.jmedchem.8b01719

Experimental method

X-RAY DIFFRACTION (2 Å)