6MVP

HCV NS5B 1b N316 bound to Compound 18

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Genome polyprotein	polymer	580	64634.1	2	UniProt (P26663) Pfam (PF00998)	Hepatitis C virus genotype 1b (isolate BK) (HCV)
2	C, D (A, B)	(4-{[5-cyclopropyl-2-(4-fluorophenyl)-3-(methylcarbamoyl)-1-benzofuran-6-yl](methylsulfonyl)amino}phenyl)boronic acid	non-polymer		522.4	2	Chemie (K4S)
3	E, F (A, B)	water	water		18.0	528	Chemie (HOH)

Sequence modifications

A, B: 1 - 570 (UniProt: P26663)

PDB	External Database	Details
Met -1	-	expression tag
Ala 0	-	expression tag
Gln 47	Leu 2466	conflict
Tyr 101	Phe 2520	conflict
Arg 114	Lys 2533	conflict
Val 329	Thr 2748	conflict
Leu 571	-	expression tag
Glu 572	-	expression tag
His 573	-	expression tag
His 574	-	expression tag
His 575	-	expression tag
His 576	-	expression tag
His 577	-	expression tag
His 578	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	129268.2
Non-Polymers*	Number of molecules	2
	Total formula weight	1044.7
All*	Total formula weight	130312.9

*Water molecules are not included.