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2Z1B	Crystal Structure of 5-aminolevulinic acid dehydratase (ALAD) from Mus musculs Descriptor: Delta-aminolevulinic acid dehydratase Authors: Xie, Y, Wang, H, Kawazoe, M, Kishishita, S, Murayama, K, Takemoto, C, Terada, T, Shirozu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) Deposit date: 2007-05-08 Release date: 2008-05-13 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (3.3 Å) Cite: Crystal Structure of 5-aminolevulinic acid dehydratase (ALAD) from Mus musculs To be Published
4V2P	Ketosynthase MxnB Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, CHLORIDE ION, KETOSYNTHASE, ... Authors: Koehnke, J. Deposit date: 2014-10-13 Release date: 2015-08-26 Last modified: 2018-04-18 Method: X-RAY DIFFRACTION (1.67 Å) Cite: In vitro reconstitution of alpha-pyrone ring formation in myxopyronin biosynthesis. Chem Sci, 6, 2015
5BNM	E. coli FabH with Small Molecule Inhibitor 1 Descriptor: 3-oxoacyl-[acyl-carrier-protein] synthase 3, N-{[3'-(hydroxymethyl)biphenyl-4-yl]methyl}benzenesulfonamide, SULFATE ION, ... Authors: Kazmirski, S.L, McKinney, D.C. Deposit date: 2015-05-26 Release date: 2016-05-18 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Antibacterial FabH Inhibitors with Mode of Action Validated in Haemophilus influenzae by in Vitro Resistance Mutation Mapping. Acs Infect Dis., 2, 2016
5BNS	E. coli Fabh with small molecule inhibitor 2 Descriptor: 1-{5-[2-fluoro-5-(hydroxymethyl)phenyl]pyridin-2-yl}-N-(quinolin-6-ylmethyl)piperidine-4-carboxamide, 3-oxoacyl-[acyl-carrier-protein] synthase 3 Authors: Kazmirski, S.L, McKinney, D.C. Deposit date: 2015-05-26 Release date: 2016-05-18 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Antibacterial FabH Inhibitors with Mode of Action Validated in Haemophilus influenzae by in Vitro Resistance Mutation Mapping. Acs Infect Dis., 2, 2016
6U0J	Crosslinked Crystal Structure of Malonyl-CoA Acyl Carrier Protein Transacylase, FabD, and Acyl Carrier Protein, AcpP Descriptor: 1,2-ETHANEDIOL, Acyl carrier protein, Malonyl CoA-acyl carrier protein transacylase, ... Authors: Mindrebo, J.T, Misson, L, Davis, T.D, Burkart, M.D, Noel, J.P. Deposit date: 2019-08-14 Release date: 2020-07-22 Last modified: 2020-10-14 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Interfacial plasticity facilitates high reaction rate of E. coli FAS malonyl-CoA:ACP transacylase, FabD. Proc.Natl.Acad.Sci.USA, 117, 2020
3T6S	Crystal structure of CerJ from Streptomyces tendae in Complex with CoA Descriptor: COENZYME A, CerJ Authors: Zocher, G, Bretschneider, T, Hertweck, C, Stehle, T. Deposit date: 2011-07-29 Release date: 2011-12-21 Last modified: 2017-11-08 Method: X-RAY DIFFRACTION (2 Å) Cite: A ketosynthase homolog uses malonyl units to form esters in cervimycin biosynthesis. Nat.Chem.Biol., 8, 2011
3T8E	Crystal structure of CerJ from Streptomyces tendae soaked with CerviK Descriptor: ACETATE ION, CerJ Authors: Zocher, G, Bretschneider, T, Hertweck, C, Stehle, T. Deposit date: 2011-08-01 Release date: 2011-12-21 Last modified: 2017-11-08 Method: X-RAY DIFFRACTION (2.1 Å) Cite: A ketosynthase homolog uses malonyl units to form esters in cervimycin biosynthesis. Nat.Chem.Biol., 8, 2011
3S3L	Crystal Structure of CerJ from Streptomyces tendae Descriptor: ACETATE ION, CHLORIDE ION, CerJ Authors: Zocher, G, Hertweck, C, Bretschneider, T, Stehle, T. Deposit date: 2011-05-18 Release date: 2011-12-21 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2 Å) Cite: A ketosynthase homolog uses malonyl units to form esters in cervimycin biosynthesis. Nat.Chem.Biol., 8, 2011
5W2P	Crystal structure of Mycobacterium tuberculosis KasA in complex with 6U5 Descriptor: 3,3',3''-phosphanetriyltripropanoic acid, 3-oxoacyl-[acyl-carrier-protein] synthase 1, GLYCEROL, ... Authors: Capodagli, G.C, Neiditch, M.B. Deposit date: 2017-06-06 Release date: 2018-12-05 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2 Å) Cite: Synergistic Lethality of a Binary Inhibitor of Mycobacterium tuberculosis KasA. MBio, 9, 2018
2GFW	Structure of wild type E. coli FabF (KASII) Descriptor: 3-oxoacyl-[acyl-carrier-protein] synthase 2 Authors: Soisson, S.M, Parthasarathy, G. Deposit date: 2006-03-23 Release date: 2006-05-23 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Platensimycin is a selective FabF inhibitor with potent antibiotic properties. Nature, 441, 2006
2GFX	Structure of E. coli FabF(C163Q) in complex with Platensimycin Descriptor: 3-oxoacyl-[acyl-carrier-protein] synthase 2, PLATENSIMYCIN Authors: Soisson, S.M, Parthasarathy, G. Deposit date: 2006-03-23 Release date: 2006-05-23 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.59 Å) Cite: Platensimycin is a selective FabF inhibitor with potent antibiotic properties. Nature, 441, 2006
2GFV	Structure of E. coli FabF (KASII) C163Q mutant Descriptor: 3-oxoacyl-[acyl-carrier-protein] synthase 2 Authors: Soisson, S.M, Parthasarathy, G. Deposit date: 2006-03-23 Release date: 2006-05-23 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.29 Å) Cite: Platensimycin is a selective FabF inhibitor with potent antibiotic properties. Nature, 441, 2006
6DGA	Cronobacter turicensis RpfR quorum-sensing receptor RpfF interaction domain Descriptor: RpfR Authors: Waldron, E.J, Neiditch, M.B. Deposit date: 2018-05-17 Release date: 2019-01-02 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (1.19 Å) Cite: Structural basis of DSF recognition by its receptor RpfR and its regulatory interaction with the DSF synthase RpfF. PLoS Biol., 17, 2019
5VNS	M.tb Antigen 85C Acyl-Enzyme Intermediate with Tetrahydrolipstatin Descriptor: (2S,3S,5S)-5-[(N-FORMYL-L-LEUCYL)OXY]-2-HEXYL-3-HYDROXYHEXADECANOIC ACID, (4S)-2-METHYL-2,4-PENTANEDIOL, Diacylglycerol acyltransferase/mycolyltransferase Ag85C, ... Authors: Goins, C.M, Ronning, D.R. Deposit date: 2017-05-01 Release date: 2018-01-24 Last modified: 2019-12-11 Method: X-RAY DIFFRACTION (1.45 Å) Cite: Mycolyltransferase fromMycobacterium tuberculosisin covalent complex with tetrahydrolipstatin provides insights into antigen 85 catalysis. J. Biol. Chem., 293, 2018
5LD8	GSK3011724A cocrystallised with Mycobacterium tuberculosis H37Rv KasA Descriptor: 3-oxoacyl-[acyl-carrier-protein] synthase 1, SODIUM ION, TETRAETHYLENE GLYCOL, ... Authors: Chung, C.W, Neu, M. Deposit date: 2016-06-23 Release date: 2016-09-21 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (2.13 Å) Cite: Identification of KasA as the cellular target of an anti-tubercular scaffold. Nat Commun, 7, 2016
6KUE	The structure of BioZ from Agrobacterium tumefaciens Descriptor: 3-oxoacyl-[acyl-carrier-protein] synthase III Authors: Ouyang, S, Hongxin, G, Sitao, Z. Deposit date: 2019-09-01 Release date: 2020-09-02 Last modified: 2024-03-27 Method: X-RAY DIFFRACTION (1.992 Å) Cite: Biochemical and structural characterization of the BioZ enzyme engaged in bacterial biotin synthesis pathway. Nat Commun, 12, 2021
2QJ3	Mycobacterium tuberculosis FabD Descriptor: Malonyl CoA-acyl carrier protein transacylase, NICKEL (II) ION Authors: Ghadbane, H, Brown, A.K, Kremer, L, Besra, G.S, Futterer, K. Deposit date: 2007-07-06 Release date: 2007-09-04 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (3 Å) Cite: Structure of Mycobacterium tuberculosis mtFabD, a malonyl-CoA:acyl carrier protein transacylase (MCAT). Acta Crystallogr.,Sect.F, 63, 2007
3STW	Crystal Structure of tomato Methylketone Synthase I complexed with 2-tridecanone Descriptor: Methylketone synthase 1, tridec-12-en-2-one Authors: Auldridge, M.E, Austin, M.B, Noel, J.P. Deposit date: 2011-07-11 Release date: 2012-05-02 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.31 Å) Cite: Emergent Decarboxylase Activity and Attenuation of alpha/beta-Hydrolase Activity during the Evolution of Methylketone Biosynthesis in Tomato. Plant Cell, 24, 2012
6KVS	Staphylococcus aureus FabH with covalent inhibitor Oxa1 Descriptor: 3-oxoacyl-[acyl-carrier-protein] synthase 3, 4-chloranyl-N-[[cyclopropylmethyl(methanoyl)amino]methyl]benzamide Authors: Yuan, Y, Wang, J. Deposit date: 2019-09-05 Release date: 2020-09-09 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Crystal Structure of S. aureus FabH, beta-ketoacyl carrier protein synthase To Be Published
7PPS	apo FabB from Pseudomonas aeruginosa with single point mutation C161A Descriptor: 1,2-ETHANEDIOL, 3-oxoacyl-[acyl-carrier-protein] synthase 1, CHLORIDE ION, ... Authors: Georgiou, C, Brenk, R, Yadrykhinsky, V. Deposit date: 2021-09-15 Release date: 2021-10-13 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.3 Å) Cite: Crystal structure of Pseudomonas aeruginosa FabB C161A, a template for structure-based design for new antibiotics. F1000Res, 10, 2021
3HJM	Crystal structure of human Glutathione Transferase Pi Y108V mutant Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, CARBONATE ION, ... Authors: Parker, L.J. Deposit date: 2009-05-22 Release date: 2009-09-22 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Influence of the H-site residue 108 on human glutathione transferase P1-1 ligand binding: structure-thermodynamic relationships and thermal stability. Protein Sci., 18, 2009
3IL9	Structure of E. coli FabH Descriptor: 3-oxoacyl-[acyl-carrier-protein] synthase 3 Authors: Gajiwala, K.S, Margosiak, S, Lu, J, Cortez, J, Su, Y, Nie, Z, Appelt, K. Deposit date: 2009-08-06 Release date: 2009-08-25 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.85 Å) Cite: Crystal structures of bacterial FabH suggest a molecular basis for the substrate specificity of the enzyme. Febs Lett., 583, 2009
2WGE	Crystal structure of KasA of Mycobacterium tuberculosis with bound TLM Descriptor: 3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE 1, GLYCEROL, ISOPROPYL ALCOHOL, ... Authors: Luckner, S.R, Kisker, C. Deposit date: 2009-04-17 Release date: 2009-07-21 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Crystal Structures of Mycobacterium Tuberculosis Kasa Show Mode of Action within Cell Wall Biosynthesis and its Inhibition by Thiolactomycin Structure, 17, 2009
2WGF	Crystal structure of Mycobacterium tuberculosis C171Q KasA variant Descriptor: 3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE 1, DI(HYDROXYETHYL)ETHER, SODIUM ION, ... Authors: Luckner, S.R, Kisker, C. Deposit date: 2009-04-17 Release date: 2009-07-21 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2.15 Å) Cite: Crystal Structures of Mycobacterium Tuberculosis Kasa Show Mode of Action within Cell Wall Biosynthesis and its Inhibition by Thiolactomycin Structure, 17, 2009
2WGD	Crystal structure of KasA of Mycobacterium tuberculosis Descriptor: 3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE 1, GLYCEROL, ISOPROPYL ALCOHOL, ... Authors: Luckner, S.R, Kisker, C. Deposit date: 2009-04-17 Release date: 2009-07-21 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2.01 Å) Cite: Crystal Structures of Mycobacterium Tuberculosis Kasa Show Mode of Action within Cell Wall Biosynthesis and its Inhibition by Thiolactomycin Structure, 17, 2009

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