5BNS

E. coli Fabh with small molecule inhibitor 2

Summary for 5BNS

• Entry DOI: 10.2210/pdb5bns/pdb
• Related: 5BNM 5BNR 5BQS
• Descriptor: 3-oxoacyl-[acyl-carrier-protein] synthase 3, 1-{5-[2-fluoro-5-(hydroxymethyl)phenyl]pyridin-2-yl}-N-(quinolin-6-ylmethyl)piperidine-4-carboxamide (3 entities in total)
• Functional Keywords: fabh, fatty acid synthesis, anti-bacterials, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Escherichia coli
• Cellular location: Cytoplasm : P0A6R0
• Total number of polymer chains: 2
• Total formula weight: 68035.13

Authors

Kazmirski, S.L.,McKinney, D.C. (deposition date: 2015-05-26, release date: 2016-05-18, Last modification date: 2024-03-06)

• Primary citation: McKinney, D.C.,Eyermann, C.J.,Gu, R.F.,Hu, J.,Kazmirski, S.L.,Lahiri, S.D.,McKenzie, A.R.,Shapiro, A.B.,Breault, G.; Antibacterial FabH Inhibitors with Mode of Action Validated in Haemophilus influenzae by in Vitro Resistance Mutation Mapping.; Acs Infect Dis., 2:456-464, 2016; PubMed: 27626097; DOI: 10.1021/acsinfecdis.6b00053

Experimental method

X-RAY DIFFRACTION (2.2 Å)