2GFV

Structure of E. coli FabF (KASII) C163Q mutant

Summary for 2GFV

Entry DOI	10.2210/pdb2gfv/pdb
Related	2GFW 2GFX 2GFY
Descriptor	3-oxoacyl-[acyl-carrier-protein] synthase 2 (2 entities in total)
Functional Keywords	fabf; kasii; acyl-enzyme intermediate, transferase
Biological source	Escherichia coli
Total number of polymer chains	1
Total formula weight	44662.29
Authors	Soisson, S.M.,Parthasarathy, G. (deposition date: 2006-03-23, release date: 2006-05-23, Last modification date: 2024-02-14)
Primary citation	Wang, J.,Soisson, S.M.,Young, K.,Shoop, W.,Kodali, S.,Galgoci, A.,Painter, R.,Parthasarathy, G.,Tang, Y.S.,Cummings, R.,Ha, S.,Dorso, K.,Motyl, M.,Jayasuriya, H.,Ondeyka, J.,Herath, K.,Zhang, C.,Hernandez, L.,Allocco, J.,Basilio, A.,Tormo, J.R.,Genilloud, O.,Vicente, F.,Pelaez, F.,Colwell, L.,Lee, S.H.,Michael, B.,Felcetto, T.,Gill, C.,Silver, L.L.,Hermes, J.D.,Bartizal, K.,Barrett, J.,Schmatz, D.,Becker, J.W.,Cully, D.,Singh, S.B. Platensimycin is a selective FabF inhibitor with potent antibiotic properties. Nature, 441:358-361, 2006 Cited by PubMed: 16710421 DOI: 10.1038/nature04784 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.29 Å)

Structure validation