5LD8

GSK3011724A cocrystallised with Mycobacterium tuberculosis H37Rv KasA

Summary for 5LD8

• Entry DOI: 10.2210/pdb5ld8/pdb
• Descriptor: 3-oxoacyl-[acyl-carrier-protein] synthase 1, SODIUM ION, ~{N}-(1-methylindazol-6-yl)butane-1-sulfonamide, ... (5 entities in total)
• Functional Keywords: inhibitor, complex, kasa, mycobacterium tuberculosis, transferase
• Biological source: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
• Cellular location: Cytoplasm : P9WQD9
• Total number of polymer chains: 2
• Total formula weight: 91769.42

Authors

Chung, C.W.,Neu, M. (deposition date: 2016-06-23, release date: 2016-09-21)

• Primary citation: Abrahams, K.A.,Chung, C.W.,Ghidelli-Disse, S.,Rullas, J.,Rebollo-Lopez, M.J.,Gurcha, S.S.,Cox, J.A.,Mendoza, A.,Jimenez-Navarro, E.,Martinez-Martinez, M.S.,Neu, M.,Shillings, A.,Homes, P.,Argyrou, A.,Casanueva, R.,Loman, N.J.,Moynihan, P.J.,Lelievre, J.,Selenski, C.,Axtman, M.,Kremer, L.,Bantscheff, M.,Angulo-Barturen, I.,Izquierdo, M.C.,Cammack, N.C.,Drewes, G.,Ballell, L.,Barros, D.,Besra, G.S.,Bates, R.H.; Identification of KasA as the cellular target of an anti-tubercular scaffold.; Nat Commun, 7:12581-12581, 2016; PubMed: 27581223; DOI: 10.1038/ncomms12581

Experimental method

X-RAY DIFFRACTION (2.13 Å)