5LD8
GSK3011724A cocrystallised with Mycobacterium tuberculosis H37Rv KasA
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004315 | molecular_function | 3-oxoacyl-[acyl-carrier-protein] synthase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006633 | biological_process | fatty acid biosynthetic process |
| A | 0009274 | cellular_component | peptidoglycan-based cell wall |
| A | 0016746 | molecular_function | acyltransferase activity |
| A | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| A | 0019367 | biological_process | fatty acid elongation, saturated fatty acid |
| A | 0030497 | biological_process | fatty acid elongation |
| A | 0042802 | molecular_function | identical protein binding |
| B | 0004315 | molecular_function | 3-oxoacyl-[acyl-carrier-protein] synthase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0006633 | biological_process | fatty acid biosynthetic process |
| B | 0009274 | cellular_component | peptidoglycan-based cell wall |
| B | 0016746 | molecular_function | acyltransferase activity |
| B | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| B | 0019367 | biological_process | fatty acid elongation, saturated fatty acid |
| B | 0030497 | biological_process | fatty acid elongation |
| B | 0042802 | molecular_function | identical protein binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | binding site for residue NA A 501 |
| Chain | Residue |
| A | ASN309 |
| A | ALA310 |
| A | GLU354 |
| A | ASN399 |
| A | ASN400 |
| site_id | AC2 |
| Number of Residues | 10 |
| Details | binding site for residue 6U5 A 502 |
| Chain | Residue |
| A | PRO201 |
| A | GLU203 |
| A | PRO206 |
| A | PHE239 |
| A | ILE347 |
| A | HOH688 |
| A | GLY117 |
| A | GLU120 |
| A | GLU199 |
| A | GLY200 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | binding site for residue PG4 A 503 |
| Chain | Residue |
| A | LEU205 |
| A | PHE210 |
| A | HOH623 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | binding site for residue PG4 A 504 |
| Chain | Residue |
| A | VAL142 |
| B | GLY115 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | binding site for residue NA B 501 |
| Chain | Residue |
| B | ASN309 |
| B | ALA310 |
| B | HIS311 |
| B | GLU354 |
| B | ASN399 |
| B | ASN400 |
| site_id | AC6 |
| Number of Residues | 11 |
| Details | binding site for residue 6U5 B 502 |
| Chain | Residue |
| B | GLY117 |
| B | GLU120 |
| B | GLU199 |
| B | GLY200 |
| B | PRO201 |
| B | ILE202 |
| B | GLU203 |
| B | PRO206 |
| B | PHE239 |
| B | ILE347 |
| B | HOH717 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: For beta-ketoacyl synthase activity => ECO:0000255|PROSITE-ProRule:PRU01348, ECO:0000305|PubMed:19604480, ECO:0000305|PubMed:24108128, ECO:0000305|PubMed:24479625 |
| Chain | Residue | Details |
| A | CYS171 | |
| B | CYS171 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | ACT_SITE: For beta-ketoacyl synthase activity => ECO:0000255|PROSITE-ProRule:PRU01348 |
| Chain | Residue | Details |
| A | HIS311 | |
| A | HIS345 | |
| B | HIS311 | |
| B | HIS345 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000305|PubMed:19604480, ECO:0000305|PubMed:24108128 |
| Chain | Residue | Details |
| A | HIS311 | |
| A | HIS345 | |
| B | HIS311 | |
| B | HIS345 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 6 |
| Details | SITE: Interacts with the inhibitor thiolactomycin => ECO:0000269|PubMed:19604480, ECO:0000269|PubMed:24108128 |
| Chain | Residue | Details |
| A | CYS171 | |
| A | HIS311 | |
| A | HIS345 | |
| B | CYS171 | |
| B | HIS311 | |
| B | HIS345 |
