PDB: 2708 resultsInfo pagesStatus searchChemie searchBIRD

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5QTG	T. brucei FPPS in complex with CID 126782062 Descriptor: 2-fluoro-N,3-dimethylbenzene-1-sulfonamide, Farnesyl pyrophosphate synthase, GLYCEROL, ... Authors: Muenzker, L, Petrick, J.K, Schleberger, C, Cornaciu, I, Marquez, J.A, Jahnke, W. Deposit date: 2019-08-09 Release date: 2020-10-07 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (2.093 Å) Cite: T. brucei FPPS in complex with CID 126782062 To Be Published
3MTD	Glycogen phosphorylase complexed with 4-hydroxybenzaldehyde-4-(beta-D-glucopyranosyl)-thiosemicarbazone Descriptor: Glycogen phosphorylase, muscle form, N-({(2Z)-2-[(4-hydroxyphenyl)methylidene]hydrazino}carbonothioyl)-beta-D-glucopyranosylamine Authors: Alexacou, K.-M. Deposit date: 2010-04-30 Release date: 2011-01-05 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2.096 Å) Cite: The binding of beta-D-glucopyranosyl-thiosemicarbazone derivatives to glycogen phosphorylase: a new class of inhibitors Bioorg.Med.Chem., 18, 2010
6SI5	T. cruzi FPPS in complex with 1-methyl-5-(4,5,6,7-tetrahydrothieno[3,2-c]pyridine-5-carbonyl)pyridin-2(1H)-one Descriptor: 5-(6,7-dihydro-4~{H}-thieno[3,2-c]pyridin-5-ylcarbonyl)-1-methyl-pyridin-2-one, Farnesyl diphosphate synthase, SULFATE ION Authors: Petrick, J.K, Muenzker, L, Schleberger, C, Cornaciu, I, Clavel, D, Marquez, J.A, Jahnke, W. Deposit date: 2019-08-08 Release date: 2020-08-26 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2.097 Å) Cite: Targeting farnesyl pyrophosphate synthase of Trypanosoma cruzi by fragment-based lead discovery Thesis, 2019
2Z78	S. cerevisiae geranylgeranyl pyrophosphate synthase in complex with BPH-806 Descriptor: 3-(decyloxy)-5-(3,5-difluorophenyl)-1-(2,2-diphosphonoethyl)pyridinium, Geranylgeranyl pyrophosphate synthetase Authors: Chen, C.K.-M, Guo, R.T, Hudock, M, Cao, R, Oldfield, E, Wang, A.H.-J. Deposit date: 2007-08-16 Release date: 2008-07-08 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Inhibition of geranylgeranyl diphosphate synthase by bisphosphonates: a crystallographic and computational investigation J.Med.Chem., 51, 2008
1MJV	DISULFIDE DEFICIENT MUTANT OF VASCULAR ENDOTHELIAL GROWTH FACTOR A (C51A and C60A) Descriptor: Vascular Endothelial Growth Factor A Authors: Muller, Y.A, Heiring, C, Misselwitz, R, Welfle, K, Welfle, H. Deposit date: 2002-08-28 Release date: 2002-12-11 Last modified: 2021-10-27 Method: X-RAY DIFFRACTION (2.1 Å) Cite: The cystine knot promotes folding and not thermodynamic stability in vascular endothelial growth factor J.Biol.Chem., 277, 2002
2Z7I	S. cerevisiae geranylgeranyl pyrophosphate synthase in complex with inhibitor BPH-742 Descriptor: (2,2-DIPHOSPHONOETHYL)(DODECYL)DIMETHYLPHOSPHONIUM, Geranylgeranyl pyrophosphate synthetase, MAGNESIUM ION Authors: Guo, R.T, Chen, C.K.-M, Ko, T.-P, Cao, R, Hudock, M, Oldfield, E, Wang, A.H.-J. Deposit date: 2007-08-23 Release date: 2008-07-08 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Inhibition of geranylgeranyl diphosphate synthase by bisphosphonates: a crystallographic and computational investigation J.Med.Chem., 51, 2008
3LTQ	Structure of Interleukin 1B solved by SAD using an inserted Lanthanide Binding Tag Descriptor: ACETATE ION, Interleukin-1 beta, SULFATE ION, ... Authors: Peisach, E, Allen, K.N. Deposit date: 2010-02-16 Release date: 2011-02-16 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Engineering encodable lanthanide-binding tags into loop regions of proteins. J.Am.Chem.Soc., 133, 2011
6R37	T. brucei FPPS in complex with 2-(5-chlorobenzo[b]thiophen-3-yl)acetic acid Descriptor: (5-chloro-1-benzothiophen-3-yl)acetic acid, DIMETHYL SULFOXIDE, Farnesyl pyrophosphate synthase Authors: Muenzker, L, Petrick, J.K, Schleberger, C, Jahnke, W. Deposit date: 2019-03-19 Release date: 2020-04-08 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Targeting Trypanosoma brucei FPPS by Fragment-based drug discovery Thesis, 2019
4CTN	Glucopyranosylidene-spiro-iminothiazolidinone, a New Bicyclic Ring System: Synthesis, Derivatization, and Evaluation as Glycogen Phosphorylase Inhibitors by Enzyme Kinetic and Crystallographic Methods Descriptor: 2,3-DIHYDROXY-1,4-DITHIOBUTANE, DIMETHYL SULFOXIDE, GLYCOGEN PHOSPHORYLASE, ... Authors: Alexacou, K.M, Papakonstantinou, M, Leonidas, D.D, Zographos, S.E, Chrysina, E.D. Deposit date: 2014-03-15 Release date: 2014-08-06 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Glucopyranosylidene-Spiro-Iminothiazolidinone, a New Bicyclic Ring System: Synthesis, Derivatization, and Evaluation for Inhibition of Glycogen Phosphorylase by Enzyme Kinetic and Crystallographic Methods. Bioorg.Med.Chem., 22, 2014
2YHX	SEQUENCING A PROTEIN BY X-RAY CRYSTALLOGRAPHY. II. REFINEMENT OF YEAST HEXOKINASE B CO-ORDINATES AND SEQUENCE AT 2.1 ANGSTROMS RESOLUTION Descriptor: 2-deoxy-2-{[(2-methylphenyl)carbonyl]amino}-alpha-D-glucopyranose, HEXOKINASE B Authors: Steitz, T.A, Anderson, C.M, Stenkamp, R.E. Deposit date: 1978-03-20 Release date: 1978-05-23 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Sequencing a protein by x-ray crystallography. II. Refinement of yeast hexokinase B co-ordinates and sequence at 2.1 A resolution. J.Mol.Biol., 123, 1978
8EMM	Composite 70S ribosome structure for "Atomistic simulations of the E. coli ribosome provide selection criteria for translationally active substrates Descriptor: 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ... Authors: Watson, Z.L, Cate, J.H.D. Deposit date: 2022-09-28 Release date: 2023-05-31 Last modified: 2023-11-15 Method: ELECTRON MICROSCOPY (2.1 Å) Cite: Atomistic simulations of the Escherichia coli ribosome provide selection criteria for translationally active substrates. Nat.Chem., 15, 2023
6XZ7	E. coli 50S ribosomal subunit in complex with dirithromycin, fMet-Phe-tRNA(Phe) and deacylated tRNA(iMet). Descriptor: 23S rRNA, 50S ribosomal protein L10, 50S ribosomal protein L11, ... Authors: Pichkur, E.B, Polikanov, Y.S, Myasnikov, A.G, Konevega, A.L. Deposit date: 2020-02-03 Release date: 2020-07-22 Method: ELECTRON MICROSCOPY (2.1 Å) Cite: Insights into the improved macrolide inhibitory activity from the high-resolution cryo-EM structure of dirithromycin bound to theE. coli70S ribosome. Rna, 26, 2020
4OGU	The effects of Lysine 200 and Phenylalanine 239 Farnesyl Pyrophosphate Synthase (FPPS) mutations on the catalytic activity, crystal structure and inhibition by nitrogen containing bisphosphonates Descriptor: 3-METHYLBUT-3-ENYL TRIHYDROGEN DIPHOSPHATE, Farnesyl pyrophosphate synthase, MAGNESIUM ION, ... Authors: Tsoumpra, M.K, Barnett, B.L, Muniz, J.R.C, Walter, R.L, Ebetino, F.H, von Delft, F, Russell, R.G.G, Oppermann, U, Dunford, J.E. Deposit date: 2014-01-16 Release date: 2015-01-21 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.1 Å) Cite: The effects of Lysine 200 and Phenylalanine 239 Farnesyl Pyrophosphate Synthase (FPPS) mutations on the catalytic activity, crystal structure and inhibition by nitrogen containing bisphosphonates To be Published
1ILR	CRYSTAL STRUCTURE OF THE INTERLEUKIN-1 RECEPTOR ANTAGONIST Descriptor: INTERLEUKIN-1 RECEPTOR ANTAGONIST PROTEIN Authors: Schreuder, H.A, Rondeau, J.-M, Tardif, C. Deposit date: 1994-06-20 Release date: 1995-02-07 Last modified: 2017-11-29 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Refined crystal structure of the interleukin-1 receptor antagonist. Presence of a disulfide link and a cis-proline. Eur.J.Biochem., 227, 1995
4HJJ	Structure Reveals Function of the Dual Variable Domain Immunoglobulin (DVD-Ig) Molecule Descriptor: Anti-IL12 Anti-IL18 DFab Heavy Chain, Anti-IL12 Anti-IL18 DFab Light Chain, CHLORIDE ION, ... Authors: Jakob, C.G, Edalji, R, Judge, R.A, DiGiammarino, E, Li, Y, Gu, J, Ghayur, T. Deposit date: 2012-10-12 Release date: 2013-05-08 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Structure reveals function of the dual variable domain immunoglobulin (DVD-Ig[TM]) molecule MAbs, 5, 2013
4XQT	Crystal structure of human FPPS in complex with three magnesium ions Descriptor: Farnesyl pyrophosphate synthase, MAGNESIUM ION, SULFATE ION Authors: Park, J, Berghuis, A.M. Deposit date: 2015-01-20 Release date: 2016-01-20 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Crystal structure of human FPPS in complex with three magnesium ions To Be Published
3AMV	ALLOSTERIC INHIBITION OF GLYCOGEN PHOSPHORYLASE A BY A POTENTIAL ANTIDIABETIC DRUG Descriptor: 2,3-DICARBOXY-4-(2-CHLORO-PHENYL)-1-ETHYL-5-ISOPROPOXYCARBONYL-6-METHYL-PYRIDINIUM, GLYCEROL, PROTEIN (GLYCOGEN PHOSPHORYLASE), ... Authors: Oikonomakos, N.G, Tsitsanou, K.E, Zographos, S.E, Skamnaki, V.T. Deposit date: 1999-02-18 Release date: 1999-02-26 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Allosteric inhibition of glycogen phosphorylase a by the potential antidiabetic drug 3-isopropyl 4-(2-chlorophenyl)-1,4-dihydro-1-ethyl-2-methyl-pyridine-3,5,6-tricarbo xylate. Protein Sci., 8, 1999
5UC6	Structural insights into IL-1 alpha recognition by a naphthyl-modified aptamer that mimics IL-1RI Domain III Descriptor: DNA (5'-D(*CP*G)-R(P*(85Y))-D(P*GP*AP*G)-R(P*(85Y)P*(85Y))-D(P*A)-R(P*(85Y))-D(P*GP*GP*G)-R(P*(85Y)P*(85Y))-D(P*AP*GP*AP*G)-R(P*(85Y))-D(P*CP*GP*(ATD))-3'), Interleukin-1 alpha, MAGNESIUM ION, ... Authors: Ren, X, Pyle, A. Deposit date: 2016-12-21 Release date: 2017-10-11 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Structural basis for IL-1 alpha recognition by a modified DNA aptamer that specifically inhibits IL-1 alpha signaling. Nat Commun, 8, 2017
3RYE	Human FDPS Synthase in Complex with a N-Methyl Pyridinum Bisphosphonate Descriptor: 3-(2-hydroxy-2,2-diphosphonoethyl)-1-methylpyridinium, Farnesyl pyrophosphate synthase, MAGNESIUM ION, ... Authors: Evdokimov, A.G, Barnett, B.L, Ebetino, F.H, Pokross, M. Deposit date: 2011-05-11 Release date: 2011-06-01 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Human FDPS Synthase in Complex with a N-Methyl Pyridinum Bisphosphonate To be Published
5I1B	A COMPARISON OF THE HIGH RESOLUTION STRUCTURES OF HUMAN AND MURINE INTERLEUKIN-1B Descriptor: INTERLEUKIN-1 BETA Authors: Ohlendorf, D.H, Salemme, F.R. Deposit date: 1990-09-07 Release date: 1992-01-15 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (2.1 Å) Cite: A Comparison of the High Resolution Structures of Human and Murine Interleukin-1B To be Published
1P4G	Crystal structure of glycogen phosphorylase b in complex with C-(1-azido-alpha-D-glucopyranosyl)formamide Descriptor: C-(1-AZIDO-ALPHA-D-GLUCOPYRANOSYL) FORMAMIDE, Glycogen phosphorylase, muscle form, ... Authors: Chrysina, E.D, Oikonomakos, N.G, Zographos, S.E, Kosmopoulou, M.N, Bischler, N, Leonidas, D.D, Nagy, V, Somsak, L, Gergely, P, Praly, J.-P. Deposit date: 2003-04-23 Release date: 2004-05-18 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Crsytallographic Studies on alpha- and beta-D-glucopyranosyl Formamide Analogues, Inhibitors of Glycogen Phosphorylase Biocatal.Biotransfor., 21, 2003
4YBB	High-resolution structure of the Escherichia coli ribosome Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, 1,2-ETHANEDIOL, 1,4-DIAMINOBUTANE, ... Authors: Noeske, J, Wasserman, M.R, Terry, D.S, Altman, R.B, Blanchard, S.C, Cate, J.H.D. Deposit date: 2015-02-18 Release date: 2015-03-18 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.1 Å) Cite: High-resolution structure of the Escherichia coli ribosome. Nat.Struct.Mol.Biol., 22, 2015
7NZ1	Respiratory complex I from Escherichia coli - focused refinement of cytoplasmic arm Descriptor: CALCIUM ION, FE2/S2 (INORGANIC) CLUSTER, FLAVIN MONONUCLEOTIDE, ... Authors: Kolata, P, Efremov, R.G. Deposit date: 2021-03-23 Release date: 2021-08-18 Method: ELECTRON MICROSCOPY (2.1 Å) Cite: Structure of Escherichia coli respiratory complex I reconstituted into lipid nanodiscs reveals an uncoupled conformation. Elife, 10, 2021
8A70	PcIDS1 in complex with Mg2+ and GPP Descriptor: GERANYL DIPHOSPHATE, Isoprenyl diphosphate synthase, MAGNESIUM ION Authors: Ecker, F, Boland, W, Groll, M. Deposit date: 2022-06-20 Release date: 2023-05-31 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Metal-dependent enzyme symmetry guides the biosynthetic flux of terpene precursors. Nat.Chem., 15, 2023
8UD1	High resolution in-situ structure of complex I in respiratory supercomplex (composite) Descriptor: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-Distearoyl-sn-glycerophosphoethanolamine, CARDIOLIPIN, ... Authors: Zheng, W, Zhu, J, Zhang, K. Deposit date: 2023-09-27 Release date: 2024-06-19 Last modified: 2024-07-17 Method: ELECTRON MICROSCOPY (2.1 Å) Cite: High-resolution in situ structures of mammalian respiratory supercomplexes. Nature, 631, 2024

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