2Z7I

S. cerevisiae geranylgeranyl pyrophosphate synthase in complex with inhibitor BPH-742

Summary for 2Z7I

Entry DOI	10.2210/pdb2z7i/pdb
Related	2Z7H
Descriptor	Geranylgeranyl pyrophosphate synthetase, MAGNESIUM ION, (2,2-DIPHOSPHONOETHYL)(DODECYL)DIMETHYLPHOSPHONIUM, ... (4 entities in total)
Functional Keywords	prenyltransferase, geranylgeranyl pyrophosphate, bisphosphonate, carotenoid biosynthesis, isoprene biosynthesis, multifunctional enzyme, protein transport, transport, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Saccharomyces cerevisiae (Baker's yeast)
Cellular location	Cytoplasm (By similarity): Q12051
Total number of polymer chains	2
Total formula weight	79485.51
Authors	Guo, R.T.,Chen, C.K.-M.,Ko, T.-P.,Cao, R.,Hudock, M.,Oldfield, E.,Wang, A.H.-J. (deposition date: 2007-08-23, release date: 2008-07-08, Last modification date: 2023-11-01)
Primary citation	Chen, C.K.-M.,Hudock, M.P.,Zhang, Y.,Guo, R.-T.,Cao, R.,No, J.H.,Liang, P.-H.,Ko, T.-P.,Chang, T.-H.,Chang, S.-C.,Song, Y.,Axelson, J.,Kumar, A.,Wang, A.H.-J.,Oldfield, E. Inhibition of geranylgeranyl diphosphate synthase by bisphosphonates: a crystallographic and computational investigation J.Med.Chem., 51:5594-5607, 2008 Cited by PubMed: 18800762 DOI: 10.1021/jm800325y PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation