6W5X
 
 | | Crystal structure of human polymerase eta complexed with N7-benzylguanine and dCTP* | | Descriptor: | 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]cytidine, DNA (5'-D(*AP*GP*TP*GP*TP*GP*AP*G)-3'), DNA (5'-D(*CP*AP*TP*(DRG)P*CP*TP*CP*AP*CP*AP*CP*T)-3'), ... | | Authors: | Jung, H, Lee, S. | | Deposit date: | 2020-03-14 | | Release date: | 2021-03-17 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (2.59 Å) | | Cite: | Crystal structure of human polymerase eta complexed with N7-benzylguanine and dCTP*
To Be Published
|
|
6WK6
 | | Crystal structure of human polymerase eta complexed with Xanthine containing DNA | | Descriptor: | 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]cytidine, DNA (5'-D(*AP*GP*TP*GP*TP*GP*AP*G)-3'), DNA (5'-D(*CP*AP*TP*(3ZO)P*CP*TP*CP*AP*CP*AP*CP*T)-3'), ... | | Authors: | Jung, H, Lee, S. | | Deposit date: | 2020-04-15 | | Release date: | 2021-01-06 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (2.35 Å) | | Cite: | Structural insights into the bypass of the major deaminated purines by translesion synthesis DNA polymerase.
Biochem.J., 477, 2020
|
|
6M7T
 | | Human DNA polymerase eta in a non-productive ternary complex with Ca2+ and dTTP oppositing cdA | | Descriptor: | 1,2-ETHANEDIOL, CALCIUM ION, DNA (5'-D(*AP*GP*TP*GP*TP*GP*AP*G)-3'), ... | | Authors: | Weng, P, Gao, Y, Yang, W. | | Deposit date: | 2018-08-21 | | Release date: | 2018-09-12 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Bypassing a 8,5'-cyclo-2'-deoxyadenosine lesion by human DNA polymerase eta at atomic resolution.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
|
|
6M7U
 | | Human DNA polymerase eta in a non-productive ternary complex with Mg2+ and dTMPNPP oppositing cdA | | Descriptor: | 5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]thymidine, CHLORIDE ION, DNA (5'-D(*AP*GP*TP*GP*TP*GP*AP*G)-3'), ... | | Authors: | Weng, P, Gao, Y, Yang, W. | | Deposit date: | 2018-08-21 | | Release date: | 2018-09-12 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (3.4 Å) | | Cite: | Bypassing a 8,5'-cyclo-2'-deoxyadenosine lesion by human DNA polymerase eta at atomic resolution.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
|
|
5EWG
 | | Ternary complex of human DNA polymerase eta inserting rATP opposite an 8-Oxodeoxyguanosine Lesion | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, CALCIUM ION, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), ... | | Authors: | Su, Y, Egli, M, Guengerich, F.P. | | Deposit date: | 2015-11-20 | | Release date: | 2016-01-13 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (1.75 Å) | | Cite: | Mechanism of Ribonucleotide Incorporation by Human DNA Polymerase eta.
J.Biol.Chem., 291, 2016
|
|
5EWF
 | | Ternary complex of human DNA polymerase eta inserting rCTP opposite an 8-Oxodeoxyguanosine Lesion | | Descriptor: | CALCIUM ION, CYTIDINE-5'-TRIPHOSPHATE, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), ... | | Authors: | Su, Y, Egli, M, Guengerich, F.P. | | Deposit date: | 2015-11-20 | | Release date: | 2016-01-13 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (1.782 Å) | | Cite: | Mechanism of Ribonucleotide Incorporation by Human DNA Polymerase eta.
J.Biol.Chem., 291, 2016
|
|
6PL8
 | |
5EWE
 | | Ternary complex of human DNA polymerase eta inserting rCTP opposite template G | | Descriptor: | CALCIUM ION, CYTIDINE-5'-TRIPHOSPHATE, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), ... | | Authors: | Su, Y, Egli, M, Guengerich, F.P. | | Deposit date: | 2015-11-20 | | Release date: | 2016-01-13 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (1.66 Å) | | Cite: | Mechanism of Ribonucleotide Incorporation by Human DNA Polymerase eta.
J.Biol.Chem., 291, 2016
|
|
6MXO
 | | Structure of HPoleta incorporating dCTP opposite the 3-prime Pt(DACH)-GG | | Descriptor: | (cyclohex-1-ene-1,2-diamine)platinum(2+), 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]cytidine, DNA (5'-D(*AP*CP*GP*GP*CP*TP*CP*AP*CP*AP*CP*T)-3'), ... | | Authors: | Ouzon-Shubeita, H, Lee, S. | | Deposit date: | 2018-10-31 | | Release date: | 2019-02-13 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (2.04 Å) | | Cite: | Structural basis for the bypass of the major oxaliplatin-DNA adducts by human DNA polymerase eta.
Biochem. J., 476, 2019
|
|
6MP3
 | |
5F9L
 | |
6PLC
 | |
6MQ8
 | | Binary structure of DNA polymerase eta in complex with templating hypoxanthine | | Descriptor: | 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]cytidine, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), DNA (5'-D(*CP*AP*TP*IP*AP*TP*GP*AP*CP*GP*CP*T)-3'), ... | | Authors: | Hawkins, M.A, Jung, H, Lee, S. | | Deposit date: | 2018-10-09 | | Release date: | 2019-10-23 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (1.969 Å) | | Cite: | Structural insights into the bypass of the major deaminated purines by translesion synthesis DNA polymerase.
Biochem.J., 2020
|
|
6PL7
 | |
6Q02
 | |
5F9N
 | |
6PZ3
 | |
3MR3
 | | Human DNA polymerase eta - DNA ternary complex with the 3'T of a CPD in the active site (TT1) | | Descriptor: | 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]adenosine, DNA (5'-D(*CP*AP*(TTD)P*AP*TP*GP*AP*CP*GP*CP*T)-3'), DNA (5'-D(*CP*AP*GP*CP*GP*TP*CP*AP*T)-3'), ... | | Authors: | Biertumpfel, C, Zhao, Y, Ramon-Maiques, S, Gregory, M.T, Lee, J.Y, Yang, W. | | Deposit date: | 2010-04-28 | | Release date: | 2010-06-30 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (1.75 Å) | | Cite: | Structure and mechanism of human DNA polymerase eta.
Nature, 465, 2010
|
|
3MR5
 | | Human DNA polymerase eta - DNA ternary complex with a CPD 1bp upstream of the active site (TT3) | | Descriptor: | 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]guanosine, DNA (5'-D(*AP*CP*GP*TP*CP*AP*TP*AP*A)-3'), DNA (5'-D(*TP*AP*AP*CP*(TTD)P*AP*TP*GP*AP*CP*GP*A)-3'), ... | | Authors: | Biertumpfel, C, Zhao, Y, Ramon-Maiques, S, Gregory, M.T, Lee, J.Y, Yang, W. | | Deposit date: | 2010-04-28 | | Release date: | 2010-06-30 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Structure and mechanism of human DNA polymerase eta.
Nature, 465, 2010
|
|
4O3N
 | | Crystal structure of human dna polymerase eta in ternary complex with native dna and incoming nucleotide (dcp) | | Descriptor: | 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]cytidine, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), DNA (5'-D(*CP*AP*TP*GP*AP*TP*GP*AP*CP*GP*CP*T)-3'), ... | | Authors: | Patra, A, Egli, M. | | Deposit date: | 2013-12-18 | | Release date: | 2014-04-30 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (1.579 Å) | | Cite: | Kinetics, Structure, and Mechanism of 8-Oxo-7,8-dihydro-2'-deoxyguanosine Bypass by Human DNA Polymerase eta
J.Biol.Chem., 289, 2014
|
|
4O3R
 | | Crystal structure of human polymerase eta extending an 8-oxog dna lesion: post insertion of 8-oxog-da pair | | Descriptor: | 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]cytidine, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*A)-3'), DNA (5'-D(*CP*AP*TP*GP*(8OG)P*TP*GP*AP*CP*GP*CP*T)-3'), ... | | Authors: | Patra, A, Egli, M. | | Deposit date: | 2013-12-18 | | Release date: | 2014-04-30 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (1.62 Å) | | Cite: | Kinetics, Structure, and Mechanism of 8-Oxo-7,8-dihydro-2'-deoxyguanosine Bypass by Human DNA Polymerase eta
J.Biol.Chem., 289, 2014
|
|
4O3P
 | | Crystal structure of human polymerase eta inserting dctp opposite an 8-oxog containing dna template | | Descriptor: | 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]cytidine, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), DNA (5'-D(*CP*AP*TP*(8OG)P*AP*TP*GP*AP*CP*GP*CP*T)-3'), ... | | Authors: | Patra, A, Egli, M. | | Deposit date: | 2013-12-18 | | Release date: | 2014-04-30 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (1.72 Å) | | Cite: | Kinetics, Structure, and Mechanism of 8-Oxo-7,8-dihydro-2'-deoxyguanosine Bypass by Human DNA Polymerase eta
J.Biol.Chem., 289, 2014
|
|
4O3Q
 | | Crystal structure of human polymerase eta inserting dgtp opposite an 8-oxog containing dna template | | Descriptor: | 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]guanosine, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), DNA (5'-D(*CP*AP*TP*(8OG)P*AP*TP*GP*AP*CP*GP*CP*T)-3'), ... | | Authors: | Patra, A, Egli, M. | | Deposit date: | 2013-12-18 | | Release date: | 2014-04-30 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (1.72 Å) | | Cite: | Kinetics, Structure, and Mechanism of 8-Oxo-7,8-dihydro-2'-deoxyguanosine Bypass by Human DNA Polymerase eta
J.Biol.Chem., 289, 2014
|
|
4RNN
 | |
4RU9
 | |
