PDB: 118 resultsInfo pagesStatus searchChemie searchBIRD

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3QLC	Complex structure of ATRX ADD domain bound to unmodified H3 1-15 peptide Descriptor: Transcriptional regulator ATRX, ZINC ION, peptide of Histone H3.3 Authors: Li, H, Patel, D.J. Deposit date: 2011-02-02 Release date: 2011-06-15 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2.5 Å) Cite: ATRX ADD domain links an atypical histone methylation recognition mechanism to human mental-retardation syndrome Nat.Struct.Mol.Biol., 18, 2011
3QO2	Structural insights for MPP8 chromodomain interaction with histone H3 lysine 9 Descriptor: 1,2-ETHANEDIOL, Histone H3 peptide, M-phase phosphoprotein 8 Authors: Chang, Y, Horton, J.R, Bedford, M.T, Zhang, X, Cheng, X. Deposit date: 2011-02-09 Release date: 2011-04-06 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.49 Å) Cite: Structural insights for MPP8 chromodomain interaction with histone H3 lysine 9: potential effect of phosphorylation on methyl-lysine binding. J.Mol.Biol., 408, 2011
2RSN	Solution structure of the chromodomain of Chp1 in complex with H3K9me3 peptide Descriptor: Chromo domain-containing protein 1, peptide from Histone H3 Authors: Shimojo, H, Nishimura, Y. Deposit date: 2012-04-18 Release date: 2012-08-29 Last modified: 2025-03-26 Method: SOLUTION NMR Cite: Intrinsic nucleic Acid-binding activity of chp1 chromodomain is required for heterochromatic gene silencing Mol.Cell, 47, 2012
6VFO	Solution structure of the PHD of mouse UHRF1 (NP95) Descriptor: E3 ubiquitin-protein ligase UHRF1, ZINC ION Authors: Lemak, A, Houliston, S, Duan, S, Arrowsmith, C.H. Deposit date: 2020-01-06 Release date: 2020-06-17 Last modified: 2024-05-15 Method: SOLUTION NMR Cite: Alternative splicing and allosteric regulation modulate the chromatin binding of UHRF1. Nucleic Acids Res., 48, 2020
6VEE	Solution structure of the TTD and linker region of mouse UHRF1 (NP95) Descriptor: E3 ubiquitin-protein ligase UHRF1 Authors: Lemak, A, Houliston, S, Duan, S, Arrowsmith, C.H. Deposit date: 2019-12-31 Release date: 2020-06-17 Last modified: 2024-05-15 Method: SOLUTION NMR Cite: Alternative splicing and allosteric regulation modulate the chromatin binding of UHRF1. Nucleic Acids Res., 48, 2020
6VED	Solution structure of the TTD and linker region of UHRF1 Descriptor: E3 ubiquitin-protein ligase UHRF1 Authors: Lemak, A, Houliston, S, Duan, S, Ong, M.S, Arrowsmith, C.H. Deposit date: 2019-12-31 Release date: 2020-06-17 Last modified: 2024-05-15 Method: SOLUTION NMR Cite: Alternative splicing and allosteric regulation modulate the chromatin binding of UHRF1. Nucleic Acids Res., 48, 2020
7M5U	Crystal structure of human MPP8 chromodomain in complex with peptidomimetic ligand UNC5246 Descriptor: M-phase phosphoprotein 8, UNC5246 Authors: Budziszewski, G.R, McGinty, R.K, Waybright, J.M, Norris, J.L, James, L.I. Deposit date: 2021-03-24 Release date: 2021-09-01 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.02 Å) Cite: A Peptidomimetic Ligand Targeting the Chromodomain of MPP8 Reveals HRP2's Association with the HUSH Complex. Acs Chem.Biol., 16, 2021
4IUR	crystal structure of SHH1 SAWADEE domain in complex with H3K9me3 peptide Descriptor: CYMAL-4, Histone H3.2, H3(1-15)K9me3, ... Authors: Patel, D.J, Du, J. Deposit date: 2013-01-21 Release date: 2013-05-01 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.501 Å) Cite: Polymerase IV occupancy at RNA-directed DNA methylation sites requires SHH1. Nature, 498, 2013
6SWG	Crystal structure of the TASOR-Periphilin core complex Descriptor: Periphilin-1, Protein TASOR, SULFATE ION Authors: Prigozhin, D.M, Freund, S.M.V, Modis, Y. Deposit date: 2019-09-20 Release date: 2020-08-05 Last modified: 2024-05-15 Method: X-RAY DIFFRACTION (2.51 Å) Cite: Periphilin self-association underpins epigenetic silencing by the HUSH complex. Nucleic Acids Res., 48, 2020
6MHA	dHP1 Chromodomain Y24W variant bound to histone H3 peptide containing trimethyllysine Descriptor: Heterochromatin protein 1, histone H3 peptide containing trimethyllysine, H3K9me3 Authors: Brustad, E.M, Krone, M.W, Albanese, K.I, Waters, M.L. Deposit date: 2018-09-17 Release date: 2019-09-25 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.497 Å) Cite: Thermodynamic consequences of Tyr to Trp mutations in the cation-pi-mediated binding of trimethyllysine by the HP1 chromodomain Chem Sci, 11, 2020
8QFB	Crystal structure of human MPP8 C-terminal region (residues 565-860) Descriptor: M-phase phosphoprotein 8 Authors: Prigozhin, D.M, Modis, Y. Deposit date: 2023-09-04 Release date: 2024-09-11 Last modified: 2024-12-25 Method: X-RAY DIFFRACTION (3.04 Å) Cite: Structure and Methyl-lysine Binding Selectivity of the HUSH Complex Subunit MPP8. J.Mol.Biol., 437, 2024
6V2S	Crystal Structure of chromodomain of MPP8 in complex with inhibitor UNC3866 Descriptor: M-phase phosphoprotein 8, UNC3866, UNKNOWN ATOM OR ION Authors: Liu, Y, Tempel, W, Walker, J.R, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) Deposit date: 2019-11-25 Release date: 2019-12-25 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Structural Basis for the Binding Selectivity of Human CDY Chromodomains. Cell Chem Biol, 27, 2020
6D07	Crystal structure of the complex between human chromobox homolog 1 (CBX1) and H3K9me3 peptide Descriptor: Chromobox protein homolog 1, GLYCEROL, Histone H3.1 Authors: Arora, S, Horne, W.S, Islam, K. Deposit date: 2018-04-10 Release date: 2019-04-10 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Engineering Methyllysine Writers and Readers for Allele-Specific Regulation of Protein-Protein Interactions. J.Am.Chem.Soc., 141, 2019
7EF2	Crystal structure of maize SHH2 SAWADEE domain in complex with an H3K9me3 peptide Descriptor: HB transcription factor, Histone H3.2, ZINC ION Authors: Wang, Y, Du, J. Deposit date: 2021-03-20 Release date: 2021-06-30 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2 Å) Cite: Recognition of H3K9me1 by maize RNA-directed DNA methylation factor SHH2. J Integr Plant Biol, 63, 2021
3G7L	Chromodomain of Chp1 in complex with Histone H3K9me3 peptide Descriptor: ACETIC ACID, Chromo domain-containing protein 1, Histone H3.1/H3.2, ... Authors: Schalch, T, Joshua-Tor, L. Deposit date: 2009-02-10 Release date: 2009-04-21 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.2 Å) Cite: High-affinity binding of Chp1 chromodomain to K9 methylated histone H3 is required to establish centromeric heterochromatin Mol.Cell, 34, 2009
2RVN	Solution structure of the chromodomain of HP1a with the phosphorylated N-terminal tail complexed with H3K9me3 peptide Descriptor: 18-mer peptide of Histone H3, Chromobox protein homolog 5 Authors: Kawaguchi, A, Nishimura, Y. Deposit date: 2015-12-18 Release date: 2016-03-16 Last modified: 2025-03-26 Method: SOLUTION NMR Cite: Extended string-like binding of the phosphorylated HP1 alpha N-terminal tail to the lysine 9-methylated histone H3 tail Sci Rep, 6, 2016
5IAY	NMR structure of UHRF1 Tandem Tudor Domains in a complex with Spacer peptide Descriptor: E3 ubiquitin-protein ligase UHRF1, Spacer Authors: Fang, J, Cheng, J, Wang, J, Zhang, Q, Liu, M, Gong, R, Wang, P, Zhang, X, Feng, Y, Lan, W, Gong, Z, Tang, C, Wong, J, Yang, H, Cao, C, Xu, Y. Deposit date: 2016-02-22 Release date: 2016-04-20 Last modified: 2024-05-01 Method: SOLUTION NMR Cite: Hemi-methylated DNA opens a closed conformation of UHRF1 to facilitate its histone recognition Nat Commun, 7, 2016
4HOO	Crystal structure of human JMJD2D/KDM4D apoenzyme Descriptor: ACETATE ION, Lysine-specific demethylase 4D, NICKEL (II) ION, ... Authors: Krishnan, S, Trievel, R.C. Deposit date: 2012-10-22 Release date: 2012-11-21 Last modified: 2024-11-20 Method: X-RAY DIFFRACTION (2.495 Å) Cite: Structural and Functional Analysis of JMJD2D Reveals Molecular Basis for Site-Specific Demethylation among JMJD2 Demethylases. Structure, 21, 2013
9BAP	CryoEM structure of Apo-DIM2 Descriptor: DNA (cytosine-5-)-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE, ZINC ION Authors: Song, J, Shao, Z. Deposit date: 2024-04-04 Release date: 2024-07-24 Last modified: 2025-02-05 Method: ELECTRON MICROSCOPY (2.88 Å) Cite: Multi-layered heterochromatin interaction as a switch for DIM2-mediated DNA methylation. Nat Commun, 15, 2024
9BAZ	CryoEM structure of DIM2-HP1 complex Descriptor: DNA (cytosine-5-)-methyltransferase, Heterochromatin protein one, S-ADENOSYL-L-HOMOCYSTEINE, ... Authors: Song, J, Shao, Z. Deposit date: 2024-04-05 Release date: 2024-07-24 Last modified: 2025-02-05 Method: ELECTRON MICROSCOPY (2.76 Å) Cite: Multi-layered heterochromatin interaction as a switch for DIM2-mediated DNA methylation. Nat Commun, 15, 2024
7BU9	Crystal Structure of Spindlin1-H3(K4me3-K9me2) complex Descriptor: H3(K4me3-K9me2) peptide, Spindlin-1 Authors: Zhao, F, Li, H. Deposit date: 2020-04-05 Release date: 2020-10-14 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (3.502 Å) Cite: Molecular basis for histone H3 "K4me3-K9me3/2" methylation pattern readout by Spindlin1. J.Biol.Chem., 295, 2020
7BQZ	Crystal Structure of Spindlin1 bound to H3(K4me3-K9me3) peptide Descriptor: H3(K4me3-K9me3) peptide, Spindlin-1 Authors: Zhao, F, Li, H. Deposit date: 2020-03-26 Release date: 2020-10-14 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (3.101 Å) Cite: Molecular basis for histone H3 "K4me3-K9me3/2" methylation pattern readout by Spindlin1. J.Biol.Chem., 295, 2020
3AVR	Catalytic fragment of UTX/KDM6A bound with histone H3K27me3 peptide, N-oxyalylglycine, and Ni(II) Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, Histone H3, ... Authors: Sengoku, T, Yokoyama, S. Deposit date: 2011-03-07 Release date: 2011-10-19 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (1.803 Å) Cite: Structural basis for histone H3 Lys 27 demethylation by UTX/KDM6A Genes Dev., 25, 2011
3AVS	Catalytic fragment of UTX/KDM6A bound with N-oxyalylglycine, and Ni(II) Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, Lysine-specific demethylase 6A, ... Authors: Sengoku, T, Yokoyama, S. Deposit date: 2011-03-07 Release date: 2011-10-19 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (1.85 Å) Cite: Structural basis for histone H3 Lys 27 demethylation by UTX/KDM6A Genes Dev., 25, 2011
3U5M	Crystal structure of TRIM33 PHD-Bromo in the free state Descriptor: CALCIUM ION, E3 ubiquitin-protein ligase TRIM33, ZINC ION Authors: Wang, Z, Patel, D.J. Deposit date: 2011-10-11 Release date: 2012-01-18 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (3.08 Å) Cite: A poised chromatin platform for TGF-beta access to master regulators Cell(Cambridge,Mass.), 147, 2011

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